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Results: 1 to 20 of 131

1.

Competition for RISC binding predicts in vitro potency of siRNA.

Koller E, Propp S, Murray H, Lima W, Bhat B, Prakash TP, Allerson CR, Swayze EE, Marcusson EG, Dean NM.

Nucleic Acids Res. 2006;34(16):4467-76. Epub 2006 Aug 31.

PMID:
16945958
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Competition potency of siRNA is specified by the 5'-half sequence of the guide strand.

Yoo JW, Kim S, Lee DK.

Biochem Biophys Res Commun. 2008 Feb 29;367(1):78-83. doi: 10.1016/j.bbrc.2007.12.099. Epub 2007 Dec 27.

PMID:
18164261
[PubMed - indexed for MEDLINE]
3.

Reduced levels of Ago2 expression result in increased siRNA competition in mammalian cells.

Vickers TA, Lima WF, Nichols JG, Crooke ST.

Nucleic Acids Res. 2007;35(19):6598-610. Epub 2007 Sep 28.

PMID:
17905815
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Comprehensive evaluation of canonical versus Dicer-substrate siRNA in vitro and in vivo.

Foster DJ, Barros S, Duncan R, Shaikh S, Cantley W, Dell A, Bulgakova E, O'Shea J, Taneja N, Kuchimanchi S, Sherrill CB, Akinc A, Hinkle G, Seila White AC, Pang B, Charisse K, Meyers R, Manoharan M, Elbashir SM.

RNA. 2012 Mar;18(3):557-68. doi: 10.1261/rna.031120.111. Epub 2012 Jan 31.

PMID:
22294662
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC.

Castanotto D, Sakurai K, Lingeman R, Li H, Shively L, Aagaard L, Soifer H, Gatignol A, Riggs A, Rossi JJ.

Nucleic Acids Res. 2007;35(15):5154-64. Epub 2007 Jul 26.

PMID:
17660190
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells.

Piao X, Zhang X, Wu L, Belasco JG.

Mol Cell Biol. 2010 Mar;30(6):1486-94. doi: 10.1128/MCB.01481-09. Epub 2010 Jan 11.

PMID:
20065043
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.

Strapps WR, Pickering V, Muiru GT, Rice J, Orsborn S, Polisky BA, Sachs A, Bartz SR.

Nucleic Acids Res. 2010 Aug;38(14):4788-97. doi: 10.1093/nar/gkq206. Epub 2010 Mar 31.

PMID:
20360048
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity.

Kubo T, Yanagihara K, Takei Y, Mihara K, Sato Y, Seyama T.

Biochem Biophys Res Commun. 2012 Oct 5;426(4):571-7. doi: 10.1016/j.bbrc.2012.08.128. Epub 2012 Sep 7.

PMID:
22982308
[PubMed - indexed for MEDLINE]
9.

Potent RNAi by short RNA triggers.

Chu CY, Rana TM.

RNA. 2008 Sep;14(9):1714-9. doi: 10.1261/rna.1161908. Epub 2008 Jul 24.

PMID:
18658119
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

Dande P, Prakash TP, Sioufi N, Gaus H, Jarres R, Berdeja A, Swayze EE, Griffey RH, Bhat B.

J Med Chem. 2006 Mar 9;49(5):1624-34.

PMID:
16509579
[PubMed - indexed for MEDLINE]
11.

RNA helicase A is not required for RISC activity.

Liang XH, Crooke ST.

Biochim Biophys Acta. 2013 Oct;1829(10):1092-101. doi: 10.1016/j.bbagrm.2013.07.008. Epub 2013 Jul 26.

PMID:
23895878
[PubMed - indexed for MEDLINE]
Free Article
12.

siRNAs targeted to certain polyadenylation sites promote specific, RISC-independent degradation of messenger RNAs.

Vickers TA, Crooke ST.

Nucleic Acids Res. 2012 Jul;40(13):6223-34. doi: 10.1093/nar/gks239. Epub 2012 Mar 15.

PMID:
22422842
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

The preferred route for the degradation of silencing target RNAs in transgenic plants depends on pre-established silencing conditions.

Sanders M, Lannoo N, Maddelein W, Depicker A, Van Montagu M, Cornelissen M, Jacobs J.

Nucleic Acids Res. 2004 Jun 25;32(11):3400-9. Print 2004.

PMID:
15220468
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.

Li F, Pallan PS, Maier MA, Rajeev KG, Mathieu SL, Kreutz C, Fan Y, Sanghvi J, Micura R, Rozners E, Manoharan M, Egli M.

Nucleic Acids Res. 2007;35(19):6424-38. Epub 2007 Sep 18.

PMID:
17881374
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila.

Preall JB, He Z, Gorra JM, Sontheimer EJ.

Curr Biol. 2006 Mar 7;16(5):530-5.

PMID:
16527750
[PubMed - indexed for MEDLINE]
Free Article
16.

Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways.

Okamura K, Ishizuka A, Siomi H, Siomi MC.

Genes Dev. 2004 Jul 15;18(14):1655-66. Epub 2004 Jul 1.

PMID:
15231716
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A role for human Dicer in pre-RISC loading of siRNAs.

Sakurai K, Amarzguioui M, Kim DH, Alluin J, Heale B, Song MS, Gatignol A, Behlke MA, Rossi JJ.

Nucleic Acids Res. 2011 Mar;39(4):1510-25. doi: 10.1093/nar/gkq846. Epub 2010 Oct 23.

PMID:
20972213
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Identification of sequence features that predict competition potency of siRNAs.

Li X, Yoo JW, Lee JH, Hahn Y, Kim S, Lee DK.

Biochem Biophys Res Commun. 2010 Jul 16;398(1):92-7. doi: 10.1016/j.bbrc.2010.06.041. Epub 2010 Jun 15.

PMID:
20558136
[PubMed - indexed for MEDLINE]
19.

The 5' binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues.

Deleavey GF, Frank F, Hassler M, Wisnovsky S, Nagar B, Damha MJ.

Nucleic Acid Ther. 2013 Feb;23(1):81-7. doi: 10.1089/nat.2012.0393. Epub 2013 Jan 5.

PMID:
23289589
[PubMed - indexed for MEDLINE]
20.

RNA interference using boranophosphate siRNAs: structure-activity relationships.

Hall AH, Wan J, Shaughnessy EE, Ramsay Shaw B, Alexander KA.

Nucleic Acids Res. 2004 Nov 15;32(20):5991-6000. Print 2004.

PMID:
15545637
[PubMed - indexed for MEDLINE]
Free PMC Article

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