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Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.

Meloni AR, Fralish GB, Kelly P, Salahpour A, Chen JK, Wechsler-Reya RJ, Lefkowitz RJ, Caron MG.

Mol Cell Biol. 2006 Oct;26(20):7550-60. Epub 2006 Aug 14.


Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2.

Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA, de Sauvage F, Lefkowitz RJ.

Science. 2004 Dec 24;306(5705):2257-60.


Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.

Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W, Caron MG.

J Biol Chem. 2011 Aug 5;286(31):27676-86. doi: 10.1074/jbc.M111.234666. Epub 2011 Jun 8.


Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.

Philipp M, Fralish GB, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG.

Mol Biol Cell. 2008 Dec;19(12):5478-89. doi: 10.1091/mbc.E08-05-0448. Epub 2008 Sep 24.


Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor.

Ren XR, Reiter E, Ahn S, Kim J, Chen W, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1448-53. Epub 2005 Jan 25.


Activation of heterotrimeric G proteins by Smoothened.

Riobo NA, Saucy B, Dilizio C, Manning DR.

Proc Natl Acad Sci U S A. 2006 Aug 15;103(33):12607-12. Epub 2006 Aug 2.


Sonic hedgehog signaling by the patched-smoothened receptor complex.

Murone M, Rosenthal A, de Sauvage FJ.

Curr Biol. 1999 Jan 28;9(2):76-84.


Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.

Salcedo A, Mayor F Jr, Penela P.

EMBO J. 2006 Oct 18;25(20):4752-62. Epub 2006 Sep 28.


Beta-arrestin- and c-Src-dependent degradation of G-protein-coupled receptor kinase 2.

Penela P, Elorza A, Sarnago S, Mayor F Jr.

EMBO J. 2001 Sep 17;20(18):5129-38.


G protein-coupled receptor kinase 2 negatively regulates chemokine signaling at a level downstream from G protein subunits.

Jiménez-Sainz MC, Murga C, Kavelaars A, Jurado-Pueyo M, Krakstad BF, Heijnen CJ, Mayor F Jr, Aragay AM.

Mol Biol Cell. 2006 Jan;17(1):25-31. Epub 2005 Oct 12.


beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor.

Shenoy SK, Drake MT, Nelson CD, Houtz DA, Xiao K, Madabushi S, Reiter E, Premont RT, Lichtarge O, Lefkowitz RJ.

J Biol Chem. 2006 Jan 13;281(2):1261-73. Epub 2005 Nov 9.


Beta-arrestin-mediated localization of smoothened to the primary cilium.

Kovacs JJ, Whalen EJ, Liu R, Xiao K, Kim J, Chen M, Wang J, Chen W, Lefkowitz RJ.

Science. 2008 Jun 27;320(5884):1777-81. doi: 10.1126/science.1157983. Epub 2008 May 22.


The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila.

Molnar C, Holguin H, Mayor F Jr, Ruiz-Gomez A, de Celis JF.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7963-8. Epub 2007 May 1.


Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists.

Frank-Kamenetsky M, Zhang XM, Bottega S, Guicherit O, Wichterle H, Dudek H, Bumcrot D, Wang FY, Jones S, Shulok J, Rubin LL, Porter JA.

J Biol. 2002 Nov 6;1(2):10.


Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.

Wilbanks AM, Fralish GB, Kirby ML, Barak LS, Li YX, Caron MG.

Science. 2004 Dec 24;306(5705):2264-7.


Regulation of smoothened by Drosophila G-protein-coupled receptor kinases.

Cheng S, Maier D, Neubueser D, Hipfner DR.

Dev Biol. 2010 Jan 1;337(1):99-109. doi: 10.1016/j.ydbio.2009.10.014. Epub 2009 Oct 20.


Role of G protein-coupled receptor kinase 4 and beta-arrestin 1 in agonist-stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen-activated protein kinases.

Iacovelli L, Salvatore L, Capobianco L, Picascia A, Barletta E, Storto M, Mariggiò S, Sallese M, Porcellini A, Nicoletti F, De Blasi A.

J Biol Chem. 2003 Apr 4;278(14):12433-42. Epub 2003 Jan 7.


The hedgehog-patched signaling pathway and function in the mammalian ovary: a novel role for hedgehog proteins in stimulating proliferation and steroidogenesis of theca cells.

Spicer LJ, Sudo S, Aad PY, Wang LS, Chun SY, Ben-Shlomo I, Klein C, Hsueh AJ.

Reproduction. 2009 Aug;138(2):329-39. doi: 10.1530/REP-08-0317. Epub 2009 May 11.

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