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Results: 1 to 20 of 215

1.

Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system.

Poirier S, Prat A, Marcinkiewicz E, Paquin J, Chitramuthu BP, Baranowski D, Cadieux B, Bennett HP, Seidah NG.

J Neurochem. 2006 Aug;98(3):838-50.

PMID:
16893422
[PubMed - indexed for MEDLINE]
2.

Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

Dubuc G, Chamberland A, Wassef H, Davignon J, Seidah NG, Bernier L, Prat A.

Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1454-9. Epub 2004 Jun 3.

PMID:
15178557
[PubMed - indexed for MEDLINE]
Free Article
3.

Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

Kourimate S, Le May C, Langhi C, Jarnoux AL, Ouguerram K, Zaïr Y, Nguyen P, Krempf M, Cariou B, Costet P.

J Biol Chem. 2008 Apr 11;283(15):9666-73. doi: 10.1074/jbc.M705831200. Epub 2008 Feb 3.

PMID:
18245819
[PubMed - indexed for MEDLINE]
Free Article
4.

The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

Seidah NG, Benjannet S, Wickham L, Marcinkiewicz J, Jasmin SB, Stifani S, Basak A, Prat A, Chretien M.

Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):928-33. Epub 2003 Jan 27.

PMID:
12552133
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2.

Jeong HJ, Lee HS, Kim KS, Kim YK, Yoon D, Park SW.

J Lipid Res. 2008 Feb;49(2):399-409. Epub 2007 Oct 5.

PMID:
17921436
[PubMed - indexed for MEDLINE]
Free Article
6.

Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment.

Maxwell KN, Fisher EA, Breslow JL.

Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2069-74. Epub 2005 Jan 27.

PMID:
15677715
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.

Costet P, Cariou B, Lambert G, Lalanne F, Lardeux B, Jarnoux AL, Grefhorst A, Staels B, Krempf M.

J Biol Chem. 2006 Mar 10;281(10):6211-8. Epub 2006 Jan 6.

PMID:
16407292
[PubMed - indexed for MEDLINE]
Free Article
8.

NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Benjannet S, Rhainds D, Essalmani R, Mayne J, Wickham L, Jin W, Asselin MC, Hamelin J, Varret M, Allard D, Trillard M, Abifadel M, Tebon A, Attie AD, Rader DJ, Boileau C, Brissette L, Chrétien M, Prat A, Seidah NG.

J Biol Chem. 2004 Nov 19;279(47):48865-75. Epub 2004 Sep 9.

PMID:
15358785
[PubMed - indexed for MEDLINE]
Free Article
9.

Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation.

Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, Cohen JC, Hobbs HH.

J Biol Chem. 2007 Jun 22;282(25):18602-12. Epub 2007 Apr 23.

PMID:
17452316
[PubMed - indexed for MEDLINE]
Free Article
10.

The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis.

Mousavi SA, Berge KE, Leren TP.

J Intern Med. 2009 Dec;266(6):507-19. doi: 10.1111/j.1365-2796.2009.02167.x. Review.

PMID:
19930098
[PubMed - indexed for MEDLINE]
11.

A novel splicing variant of proprotein convertase subtilisin/kexin type 9.

Schmidt RJ, Zhang Y, Zhao Y, Qian YW, Wang H, Lin A, Ehsani ME, Yu X, Wang G, Singh J, Su EW, Li S, Konrad RJ, Cao G.

DNA Cell Biol. 2008 Apr;27(4):183-9.

PMID:
18052825
[PubMed - indexed for MEDLINE]
12.

The proprotein convertases are potential targets in the treatment of dyslipidemia.

Seidah NG, Prat A.

J Mol Med (Berl). 2007 Jul;85(7):685-96. Epub 2007 Mar 10. Review.

PMID:
17351764
[PubMed - indexed for MEDLINE]
13.

Regulation of the proprotein convertase subtilisin/kexin type 9 in intestinal epithelial cells.

Leblond F, Seidah NG, Précourt LP, Delvin E, Dominguez M, Levy E.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G805-15. doi: 10.1152/ajpgi.90424.2008. Epub 2009 Jan 29.

PMID:
19179626
[PubMed - indexed for MEDLINE]
Free Article
14.

Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.

Schmidt RJ, Beyer TP, Bensch WR, Qian YW, Lin A, Kowala M, Alborn WE, Konrad RJ, Cao G.

Biochem Biophys Res Commun. 2008 Jun 13;370(4):634-40. doi: 10.1016/j.bbrc.2008.04.004. Epub 2008 Apr 10.

PMID:
18406350
[PubMed - indexed for MEDLINE]
15.

The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2.

Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG.

J Biol Chem. 2008 Jan 25;283(4):2363-72. Epub 2007 Nov 26.

PMID:
18039658
[PubMed - indexed for MEDLINE]
Free Article
16.

Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.

Maxwell KN, Breslow JL.

Proc Natl Acad Sci U S A. 2004 May 4;101(18):7100-5. Epub 2004 Apr 26.

PMID:
15118091
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.

Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG.

J Biol Chem. 2006 Oct 13;281(41):30561-72. Epub 2006 Aug 15.

PMID:
16912035
[PubMed - indexed for MEDLINE]
Free Article
18.

Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver.

Sun X, Essalmani R, Day R, Khatib AM, Seidah NG, Prat A.

Neoplasia. 2012 Dec;14(12):1122-31.

PMID:
23308045
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM.

PLoS One. 2010 May 17;5(5):e10682. doi: 10.1371/journal.pone.0010682.

PMID:
20498851
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

PCSK9: an enigmatic protease.

Lopez D.

Biochim Biophys Acta. 2008 Apr;1781(4):184-91. doi: 10.1016/j.bbalip.2008.01.003. Epub 2008 Feb 2. Review.

PMID:
18280815
[PubMed - indexed for MEDLINE]

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