Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 178

2.
3.

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.

J Steroid Biochem Mol Biol. 2008 Jul;111(1-2):117-27. doi: 10.1016/j.jsbmb.2008.05.007. Epub 2008 Jun 21.

PMID:
18620055
4.

Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-Hydroxylase/17,20-Lyase (P45017alpha).

Shahid I, Patel CH, Dhanani S, Owen CP, Ahmed S.

J Steroid Biochem Mol Biol. 2008 May;110(1-2):18-29. doi: 10.1016/j.jsbmb.2007.10.009. Epub 2008 Feb 12.

PMID:
18407491
6.

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)).

Ahmed S, Shahid I, Dhanani S, Owen CP.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4698-701. doi: 10.1016/j.bmcl.2009.06.070. Epub 2009 Jun 21.

PMID:
19608417
7.

Synthesis and biological evaluation of imidazole based compounds as cytochrome P-450 inhibitors.

Ahmed S, Smith JH, Nicholls PJ, Whomsley R, Cariuk P.

Drug Des Discov. 1995 Aug;13(1):27-41.

PMID:
8882899
9.
10.

Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.

Bioorg Med Chem. 2008 Aug 15;16(16):7715-27. doi: 10.1016/j.bmc.2008.07.011. Epub 2008 Jul 9.

PMID:
18674917
11.
12.

Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.

Jagusch C, Negri M, Hille UE, Hu Q, Bartels M, Jahn-Hoffmann K, Pinto-Bazurco Mendieta MA, Rodenwaldt B, Müller-Vieira U, Schmidt D, Lauterbach T, Recanatini M, Cavalli A, Hartmann RW.

Bioorg Med Chem. 2008 Feb 15;16(4):1992-2010. Epub 2007 Nov 4.

PMID:
18061460
13.
16.

Synthesis and biological evaluation of 3-(azolylmethyl)-1H-indoles and 3-(alpha-azolylbenzyl)-1H-indoles as selective aromatase inhibitors.

Le Borgne M, Marchand P, Nourrisson MR, Loquet D, Palzer M, Le Baut G, Hartmann RW.

J Enzyme Inhib Med Chem. 2007 Oct;22(5):667-76.

PMID:
18035835
17.

Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.

Hille UE, Hu Q, Vock C, Negri M, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.

Eur J Med Chem. 2009 Jul;44(7):2765-75. doi: 10.1016/j.ejmech.2009.01.002. Epub 2009 Jan 19.

PMID:
19211174
18.

Synthesis and biological evaluation of novel pyrrolidine-2,5-dione inhibitors as potential anti-tumour agents.

Ahmed S, Smith JH, Nicholls PJ, Whomsley R, Cariuk P.

Drug Des Discov. 1995 Apr;12(4):275-87.

PMID:
9040988
19.
20.

Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.

Haidar S, Ehmer PB, Barassin S, Batzl-Hartmann C, Hartmann RW.

J Steroid Biochem Mol Biol. 2003 Apr;84(5):555-62.

PMID:
12767280
Items per page

Supplemental Content

Write to the Help Desk