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Items: 1 to 20 of 175

1.

Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells.

Chute JP, Muramoto GG, Whitesides J, Colvin M, Safi R, Chao NJ, McDonnell DP.

Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11707-12. Epub 2006 Jul 20.

2.

Inhibition of aldehyde dehydrogenase expands hematopoietic stem cells with radioprotective capacity.

Muramoto GG, Russell JL, Safi R, Salter AB, Himburg HA, Daher P, Meadows SK, Doan P, Storms RW, Chao NJ, McDonnell DP, Chute JP.

Stem Cells. 2010 Mar 31;28(3):523-34. doi: 10.1002/stem.299.

3.

Dual SP/ALDH functionalities refine the human hematopoietic Lin-CD34+CD38- stem/progenitor cell compartment.

Pierre-Louis O, Clay D, Brunet de la Grange P, Blazsek I, Desterke C, Guerton B, Blondeau C, Malfuson JV, Prat M, Bennaceur-Griscelli A, Lataillade JJ, Le Bousse-Kerdil├Ęs MC.

Stem Cells. 2009 Oct;27(10):2552-62. doi: 10.1002/stem.186.

4.

Functional characterization of highly purified human hematopoietic repopulating cells isolated according to aldehyde dehydrogenase activity.

Hess DA, Meyerrose TE, Wirthlin L, Craft TP, Herrbrich PE, Creer MH, Nolta JA.

Blood. 2004 Sep 15;104(6):1648-55. Epub 2004 Jun 3.

5.

Selection based on CD133 and high aldehyde dehydrogenase activity isolates long-term reconstituting human hematopoietic stem cells.

Hess DA, Wirthlin L, Craft TP, Herrbrich PE, Hohm SA, Lahey R, Eades WC, Creer MH, Nolta JA.

Blood. 2006 Mar 1;107(5):2162-9. Epub 2005 Nov 3.

6.

Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling.

Ghiaur G, Yegnasubramanian S, Perkins B, Gucwa JL, Gerber JM, Jones RJ.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16121-6. doi: 10.1073/pnas.1305937110. Epub 2013 Sep 16.

7.

Ex vivo expansion of human hematopoietic stem cells by a small-molecule agonist of c-MPL.

Nishino T, Miyaji K, Ishiwata N, Arai K, Yui M, Asai Y, Nakauchi H, Iwama A.

Exp Hematol. 2009 Nov;37(11):1364-1377.e4. doi: 10.1016/j.exphem.2009.09.001. Epub 2009 Sep 8.

PMID:
19744539
8.

Improved purification of hematopoietic stem cells based on their elevated aldehyde dehydrogenase activity.

Christ O, Lucke K, Imren S, Leung K, Hamilton M, Eaves A, Smith C, Eaves C.

Haematologica. 2007 Sep;92(9):1165-72. Epub 2007 Aug 1.

9.

Pharmacological manipulation of the RAR/RXR signaling pathway maintains the repopulating capacity of hematopoietic stem cells in culture.

Safi R, Muramoto GG, Salter AB, Meadows S, Himburg H, Russell L, Daher P, Doan P, Leibowitz MD, Chao NJ, McDonnell DP, Chute JP.

Mol Endocrinol. 2009 Feb;23(2):188-201. doi: 10.1210/me.2008-0121. Epub 2008 Dec 23.

10.

Characterization of cells with a high aldehyde dehydrogenase activity from cord blood and acute myeloid leukemia samples.

Pearce DJ, Taussig D, Simpson C, Allen K, Rohatiner AZ, Lister TA, Bonnet D.

Stem Cells. 2005 Jun-Jul;23(6):752-60.

11.

RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation.

Purton LE, Dworkin S, Olsen GH, Walkley CR, Fabb SA, Collins SJ, Chambon P.

J Exp Med. 2006 May 15;203(5):1283-93. Epub 2006 May 8. Erratum in: J Exp Med. 2006 Jun 12;203(6):1615.

12.

Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation.

Zhang CC, Kaba M, Iizuka S, Huynh H, Lodish HF.

Blood. 2008 Apr 1;111(7):3415-23. doi: 10.1182/blood-2007-11-122119. Epub 2008 Jan 17.

13.

HES1 inhibits cycling of hematopoietic progenitor cells via DNA binding.

Yu X, Alder JK, Chun JH, Friedman AD, Heimfeld S, Cheng L, Civin CI.

Stem Cells. 2006 Apr;24(4):876-88. Epub 2006 Mar 2.

14.

IFN-gamma negatively modulates self-renewal of repopulating human hemopoietic stem cells.

Yang L, Dybedal I, Bryder D, Nilsson L, Sitnicka E, Sasaki Y, Jacobsen SE.

J Immunol. 2005 Jan 15;174(2):752-7.

15.

Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells.

Yahata T, Yumino S, Seng Y, Miyatake H, Uno T, Muguruma Y, Ito M, Miyoshi H, Kato S, Hotta T, Ando K.

Blood. 2006 Oct 1;108(7):2446-54. Epub 2006 Jun 6.

16.

Expansion of human SCID-repopulating cells under hypoxic conditions.

Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC.

J Clin Invest. 2003 Jul;112(1):126-35.

17.

A DEAB-sensitive aldehyde dehydrogenase regulates hematopoietic stem and progenitor cells development during primitive hematopoiesis in zebrafish embryos.

Ma AC, Chung MI, Liang R, Leung AY.

Leukemia. 2010 Dec;24(12):2090-9. doi: 10.1038/leu.2010.206. Epub 2010 Oct 7.

PMID:
20927131
18.

Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.

Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2349-54. Epub 2007 Feb 6.

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