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Items: 1 to 20 of 107


p53 regulates mitochondrial respiration.

Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM.

Science. 2006 Jun 16;312(5780):1650-3. Epub 2006 May 25.


Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer.

Won KY, Lim SJ, Kim GY, Kim YW, Han SA, Song JY, Lee DK.

Hum Pathol. 2012 Feb;43(2):221-8. doi: 10.1016/j.humpath.2011.04.021. Epub 2011 Aug 4.


NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration.

Mauro C, Leow SC, Anso E, Rocha S, Thotakura AK, Tornatore L, Moretti M, De Smaele E, Beg AA, Tergaonkar V, Chandel NS, Franzoso G.

Nat Cell Biol. 2011 Aug 28;13(10):1272-9. doi: 10.1038/ncb2324.


p53 aerobics: the major tumor suppressor fuels your workout.

Kruse JP, Gu W.

Cell Metab. 2006 Jul;4(1):1-3. Review.


Synthesis of cytochrome C oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death.

Wanka C, Brucker DP, Bähr O, Ronellenfitsch M, Weller M, Steinbach JP, Rieger J.

Oncogene. 2012 Aug 16;31(33):3764-76. doi: 10.1038/onc.2011.530. Epub 2011 Nov 28.


p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation.

Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Adachi S, Tanaka H, Takamatsu T, Matsubara H.

Circ Heart Fail. 2012 Jan;5(1):106-15. doi: 10.1161/CIRCHEARTFAILURE.111.961565. Epub 2011 Nov 9. Erratum in: Circ Heart Fail. 2014 Mar 1;7(2):383.


Two p53-related metabolic regulators, TIGAR and SCO2, contribute to oroxylin A-mediated glucose metabolism in human hepatoma HepG2 cells.

Dai Q, Yin Y, Liu W, Wei L, Zhou Y, Li Z, You Q, Lu N, Guo Q.

Int J Biochem Cell Biol. 2013 Jul;45(7):1468-78. doi: 10.1016/j.biocel.2013.04.015. Epub 2013 Apr 21.


Regulation of glucose metabolism by p53: emerging new roles for the tumor suppressor.

Madan E, Gogna R, Bhatt M, Pati U, Kuppusamy P, Mahdi AA.

Oncotarget. 2011 Dec;2(12):948-57. Review.


Differential utilization of two ATP-generating pathways is regulated by p53.

Assaily W, Benchimol S.

Cancer Cell. 2006 Jul;10(1):4-6.


Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer.

Rajendran R, Garva R, Ashour H, Leung T, Stratford I, Krstic-Demonacos M, Demonacos C.

Int J Oncol. 2013 Jun;42(6):1961-72. doi: 10.3892/ijo.2013.1907. Epub 2013 Apr 17.


p53 Protects lung cancer cells against metabolic stress.

Sinthupibulyakit C, Ittarat W, St Clair WH, St Clair DK.

Int J Oncol. 2010 Dec;37(6):1575-81.


Physical exercise regulates p53 activity targeting SCO2 and increases mitochondrial COX biogenesis in cardiac muscle with age.

Qi Z, He J, Su Y, He Q, Liu J, Yu L, Al-Attas O, Hussain T, Ding S, Ji L, Qian M.

PLoS One. 2011;6(7):e21140. doi: 10.1371/journal.pone.0021140. Epub 2011 Jul 7.


SCO2 induces p53-mediated apoptosis by Thr845 phosphorylation of ASK-1 and dissociation of the ASK-1-Trx complex.

Madan E, Gogna R, Kuppusamy P, Bhatt M, Mahdi AA, Pati U.

Mol Cell Biol. 2013 Apr;33(7):1285-302. doi: 10.1128/MCB.06798-11. Epub 2013 Jan 14.


A pivotal role for p53: balancing aerobic respiration and glycolysis.

Ma W, Sung HJ, Park JY, Matoba S, Hwang PM.

J Bioenerg Biomembr. 2007 Jun;39(3):243-6. Review.


Human SCO1 and SCO2 have independent, cooperative functions in copper delivery to cytochrome c oxidase.

Leary SC, Kaufman BA, Pellecchia G, Guercin GH, Mattman A, Jaksch M, Shoubridge EA.

Hum Mol Genet. 2004 Sep 1;13(17):1839-48. Epub 2004 Jun 30.


Intracellular delivery of full length recombinant human mitochondrial L-Sco2 protein into the mitochondria of permanent cell lines and SCO2 deficient patient's primary cells.

Foltopoulou PF, Tsiftsoglou AS, Bonovolias ID, Ingendoh AT, Papadopoulou LC.

Biochim Biophys Acta. 2010 Jun;1802(6):497-508. doi: 10.1016/j.bbadis.2010.02.009. Epub 2010 Mar 1.


High resolution respirometry analysis of polyethylenimine-mediated mitochondrial energy crisis and cellular stress: Mitochondrial proton leak and inhibition of the electron transport system.

Hall A, Larsen AK, Parhamifar L, Meyle KD, Wu LP, Moghimi SM.

Biochim Biophys Acta. 2013 Oct;1827(10):1213-25. doi: 10.1016/j.bbabio.2013.07.001. Epub 2013 Jul 11.


Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F0-ATP synthase.

Bergeaud M, Mathieu L, Guillaume A, Moll UM, Mignotte B, Le Floch N, Vayssière JL, Rincheval V.

Cell Cycle. 2013 Sep 1;12(17):2781-93. doi: 10.4161/cc.25870. Epub 2013 Aug 6.


Effect of p53 on mitochondrial morphology, import, and assembly in skeletal muscle.

Saleem A, Iqbal S, Zhang Y, Hood DA.

Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C319-29. doi: 10.1152/ajpcell.00253.2014. Epub 2014 Dec 3.


Alpha particle-induced bystander effect is mediated by ROS via a p53-dependent SCO2 pathway in hepatoma cells.

Li J, He M, Shen B, Yuan D, Shao C.

Int J Radiat Biol. 2013 Dec;89(12):1028-34. doi: 10.3109/09553002.2013.817706. Epub 2013 Jul 24.

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