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WNK1 kinase isoform switch regulates renal potassium excretion.

Wade JB, Fang L, Liu J, Li D, Yang CL, Subramanya AR, Maouyo D, Mason A, Ellison DH, Welling PA.

Proc Natl Acad Sci U S A. 2006 May 30;103(22):8558-63. Epub 2006 May 18.


Regulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinase.

Liu Z, Wang HR, Huang CL.

J Biol Chem. 2009 May 1;284(18):12198-206. doi: 10.1074/jbc.M806551200. Epub 2009 Feb 25.


Antagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.

Lazrak A, Liu Z, Huang CL.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1615-20. Epub 2006 Jan 20.


The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.

Náray-Fejes-Tóth A, Snyder PM, Fejes-Tóth G.

Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17434-9. Epub 2004 Dec 6.


Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform.

Subramanya AR, Yang CL, Zhu X, Ellison DH.

Am J Physiol Renal Physiol. 2006 Mar;290(3):F619-24. Epub 2005 Oct 4.


Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW.

J Am Soc Nephrol. 2006 Sep;17(9):2402-13. Epub 2006 Aug 9.


WNK1 affects surface expression of the ROMK potassium channel independent of WNK4.

Cope G, Murthy M, Golbang AP, Hamad A, Liu CH, Cuthbert AW, O'Shaughnessy KM.

J Am Soc Nephrol. 2006 Jul;17(7):1867-74. Epub 2006 Jun 14.


WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K+ channel ROMK1 (Kir1.1).

Leng Q, Kahle KT, Rinehart J, MacGregor GG, Wilson FH, Canessa CM, Lifton RP, Hebert SC.

J Physiol. 2006 Mar 1;571(Pt 2):275-86. Epub 2005 Dec 15.


Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.

Cheng CJ, Baum M, Huang CL.

Am J Physiol Renal Physiol. 2013 Feb 15;304(4):F397-402. doi: 10.1152/ajprenal.00589.2012. Epub 2012 Nov 28.


Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse models.

Liu Z, Xie J, Wu T, Truong T, Auchus RJ, Huang CL.

Hum Mol Genet. 2011 Mar 1;20(5):855-66. doi: 10.1093/hmg/ddq525. Epub 2010 Dec 2.


[The effect of aldosterone A on renal potassium excretion].

Winther SA, Egfjord M.

Ugeskr Laeger. 2011 Jan 10;173(2):126-9. Danish.


Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18109-14. doi: 10.1073/pnas.1006128107. Epub 2010 Oct 4.


Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A.

Yoo D, Kim BY, Campo C, Nance L, King A, Maouyo D, Welling PA.

J Biol Chem. 2003 Jun 20;278(25):23066-75. Epub 2003 Apr 8.


The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.


WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron.

Vidal-Petiot E, Elvira-Matelot E, Mutig K, Soukaseum C, Baudrie V, Wu S, Cheval L, Huc E, Cambillau M, Bachmann S, Doucet A, Jeunemaitre X, Hadchouel J.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14366-71. doi: 10.1073/pnas.1304230110. Epub 2013 Aug 12.


Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension.

Huang CL, Kuo E.

Nat Clin Pract Nephrol. 2007 Nov;3(11):623-30. Review.


Kidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limb.

Cheng CJ, Truong T, Baum M, Huang CL.

Am J Physiol Renal Physiol. 2012 Sep;303(5):F667-73. doi: 10.1152/ajprenal.00290.2012. Epub 2012 Jul 11.


Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1/SGK1-dependent phosphorylation of WNK1.

Cheng CJ, Huang CL.

J Am Soc Nephrol. 2011 Mar;22(3):460-71. doi: 10.1681/ASN.2010060681. Epub 2011 Feb 25.


WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.


WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.

Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP.

Nat Genet. 2003 Dec;35(4):372-6. Epub 2003 Nov 9.

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