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Items: 1 to 20 of 105


Transforming growth factor-beta stimulates cyclin D1 expression through activation of beta-catenin signaling in chondrocytes.

Li TF, Chen D, Wu Q, Chen M, Sheu TJ, Schwarz EM, Drissi H, Zuscik M, O'Keefe RJ.

J Biol Chem. 2006 Jul 28;281(30):21296-304. Epub 2006 May 10.


Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation.

Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ.

J Bone Miner Res. 2006 Jan;21(1):4-16. Epub 2005 Sep 19.


Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes.

Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ.

J Cell Biochem. 2012 Jun;113(6):2156-66. doi: 10.1002/jcb.24089.


Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways.

Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ.

Ann N Y Acad Sci. 2007 Nov;1116:82-99.


Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).

Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z.

J Biol Chem. 2012 Mar 2;287(10):7026-38. doi: 10.1074/jbc.M111.276311. Epub 2012 Jan 12.


Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes.

Zhang M, Wang M, Tan X, Li TF, Zhang YE, Chen D.

J Biol Chem. 2010 Mar 19;285(12):8703-10. doi: 10.1074/jbc.M109.093526. Epub 2010 Jan 22.


Polarity of response to transforming growth factor-beta1 in proximal tubular epithelial cells is regulated by beta-catenin.

Zhang M, Lee CH, Luo DD, Krupa A, Fraser D, Phillips A.

J Biol Chem. 2007 Sep 28;282(39):28639-47. Epub 2007 Jul 9.


Altered signaling in the G1 phase deregulates chondrocyte growth in a mouse model with proteoglycan undersulfation.

De Leonardis F, Monti L, Gualeni B, Tenni R, Forlino A, Rossi A.

J Cell Biochem. 2014 Oct;115(10):1779-86. doi: 10.1002/jcb.24844.


Role of Smad3, acting independently of transforming growth factor-beta, in the early induction of Wnt-beta-catenin signaling by parathyroid hormone in mouse osteoblastic cells.

Inoue Y, Canaff L, Hendy GN, Hisa I, Sugimoto T, Chihara K, Kaji H.

J Cell Biochem. 2009 Sep 1;108(1):285-94. doi: 10.1002/jcb.22252.


Association of β-catenin with P-Smad3 but not LEF-1 dissociates in vitro profibrotic from anti-inflammatory effects of TGF-β1.

Tian X, Zhang J, Tan TK, Lyons JG, Zhao H, Niu B, Lee SR, Tsatralis T, Zhao Y, Wang Y, Cao Q, Wang C, Wang Y, Lee VW, Kahn M, Zheng G, Harris DC.

J Cell Sci. 2013 Jan 1;126(Pt 1):67-76. doi: 10.1242/jcs.103036. Epub 2012 Nov 30.


BMP2 promotes chondrocyte proliferation via the Wnt/β-catenin signaling pathway.

Li X, Peng J, Wu M, Ye H, Zheng C, Wu G, Xu H, Chen X, Liu X.

Mol Med Rep. 2011 Jul-Aug;4(4):621-6. doi: 10.3892/mmr.2011.474. Epub 2011 Apr 14.


ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.

Finnson KW, Parker WL, ten Dijke P, Thorikay M, Philip A.

J Bone Miner Res. 2008 Jun;23(6):896-906. doi: 10.1359/jbmr.080209.


Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ.

Arthritis Rheum. 2010 Aug;62(8):2359-69. doi: 10.1002/art.27537.


Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.

Dong YF, Soung do Y, Schwarz EM, O'Keefe RJ, Drissi H.

J Cell Physiol. 2006 Jul;208(1):77-86.


Wnt-mediated regulation of chondrocyte maturation: modulation by TGF-beta.

Dong Y, Drissi H, Chen M, Chen D, Zuscik MJ, Schwarz EM, O'Keefe RJ.

J Cell Biochem. 2005 Aug 1;95(5):1057-68.


PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling.

Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ.

J Cell Physiol. 2001 Sep;188(3):343-51.


Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.

Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H.

Mol Endocrinol. 2007 Nov;21(11):2805-20. Epub 2007 Aug 7.

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