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Lactacystin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.

Legnani FG, Pradilla G, Thai QA, Fiorindi A, Recinos PF, Tyler BM, Gaini SM, DiMeco F, Brem H, Olivi A.

J Neurooncol. 2006 May;77(3):225-32.


The 9L(LUC)/Wistar rat glioma model is not suitable for immunotherapy.

Yang L, Zhao J, Zhou G, Wang Y, Li L, Yuan H, Nan X, Guan L, Pei X.

Neural Regen Res. 2012 Jun 25;7(18):1406-11. doi: 10.3969/j.issn.1673-5374.2012.18.007.


Efficacy of local delivery of ardipusilloside I using biodegradable implants against cerebral tumor growth.

Dang H, Wang J, Cheng JX, Wang PY, Wang Y, Cheng LF, Du C, Wang XJ.

Am J Cancer Res. 2014 Dec 15;5(1):243-54. eCollection 2015.


5-aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.

Yamamoto J, Ogura S, Shimajiri S, Nakano Y, Akiba D, Kitagawa T, Ueta K, Tanaka T, Nishizawa S.

Mol Med Rep. 2015 Mar;11(3):1813-9. doi: 10.3892/mmr.2014.2991. Epub 2014 Nov 21.


Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma.

Wicks RT, Azadi J, Mangraviti A, Zhang I, Hwang L, Joshi A, Bow H, Hutt-Cabezas M, Martin KL, Rudek MA, Zhao M, Brem H, Tyler BM.

Neuro Oncol. 2015 Jan;17(1):70-80. doi: 10.1093/neuonc/nou143. Epub 2014 Jul 22.


Sustained delivery of cytarabine-loaded vesicular phospholipid gels for treatment of xenografted glioma.

Qi N, Cai C, Zhang W, Niu Y, Yang J, Wang L, Tian B, Liu X, Lin X, Zhang Y, Zhang Y, He H, Chen K, Tang X.

Int J Pharm. 2014 Sep 10;472(1-2):48-55. doi: 10.1016/j.ijpharm.2014.06.005. Epub 2014 Jun 7.


The impact of dietary isoflavonoids on malignant brain tumors.

Sehm T, Fan Z, Weiss R, Schwarz M, Engelhorn T, Hore N, Doerfler A, Buchfelder M, Eyüpoglu IY, Savaskan NE.

Cancer Med. 2014 Aug;3(4):865-77. doi: 10.1002/cam4.265. Epub 2014 Jun 4.


Radiosensitization of malignant gliomas following intracranial delivery of paclitaxel biodegradable polymer microspheres.

Gabikian P, Tyler BM, Zhang I, Li KW, Brem H, Walter KA.

J Neurosurg. 2014 May;120(5):1078-85. doi: 10.3171/2014.1.JNS13235. Epub 2014 Mar 7.


Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models.

Yohay K, Tyler B, Weaver KD, Pardo AC, Gincel D, Blakeley J, Brem H, Rothstein JD.

J Neurosurg. 2014 Apr;120(4):854-63. doi: 10.3171/2013.12.JNS13641. Epub 2014 Jan 31.


Local delivery of angiogenesis-inhibitor minocycline combined with radiotherapy and oral temozolomide chemotherapy in 9L glioma.

Bow H, Hwang LS, Schildhaus N, Xing J, Murray L, Salditch Q, Ye X, Zhang Y, Weingart J, Brem H, Tyler B.

J Neurosurg. 2014 Mar;120(3):662-9. doi: 10.3171/2013.11.JNS13556. Epub 2013 Dec 20.


The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model.

Awde AR, Boisgard R, Thézé B, Dubois A, Zheng J, Dollé F, Jacobs AH, Tavitian B, Winkeler A.

J Nucl Med. 2013 Dec;54(12):2125-31. doi: 10.2967/jnumed.112.118794. Epub 2013 Nov 8.


Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme.

da Silveira EF, Chassot JM, Teixeira FC, Azambuja JH, Debom G, Beira FT, Del Pino FA, Lourenço A, Horn AP, Cruz L, Spanevello RM, Braganhol E.

Invest New Drugs. 2013 Dec;31(6):1424-35. doi: 10.1007/s10637-013-0016-y. Epub 2013 Sep 27.


Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment.

Xi G, Robinson E, Mania-Farnell B, Vanin EF, Shim KW, Takao T, Allender EV, Mayanil CS, Soares MB, Ho D, Tomita T.

Nanomedicine. 2014 Feb;10(2):381-91. doi: 10.1016/j.nano.2013.07.013. Epub 2013 Aug 3.


Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma.

Sattler R, Tyler B, Hoover B, Coddington LT, Recinos V, Hwang L, Brem H, Rothstein JD.

J Neurosurg. 2013 Oct;119(4):878-86. doi: 10.3171/2013.6.JNS122319. Epub 2013 Aug 2.


Intracerebral administration of heat-inactivated Staphylococcus epidermidis enhances oncolysis and prolongs survival in a 9L orthotopic gliosarcoma model.

Löhr M, Molcanyi M, Poggenborg J, Spuentrup E, Runge M, Röhn G, Härtig W, Hescheler J, Hampl JA.

Cell Physiol Biochem. 2013;31(4-5):614-24. doi: 10.1159/000350081. Epub 2013 May 6.


The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study.

Wang H, Zhang S, Zhong J, Zhang J, Luo Y, Pengfei G.

J Int Med Res. 2013 Feb;41(1):72-81. doi: 10.1177/0300060513476992. Epub 2013 Jan 24.


Combination of paclitaxel thermal gel depot with temozolomide and radiotherapy significantly prolongs survival in an experimental rodent glioma model.

Vellimana AK, Recinos VR, Hwang L, Fowers KD, Li KW, Zhang Y, Okonma S, Eberhart CG, Brem H, Tyler BM.

J Neurooncol. 2013 Feb;111(3):229-36. doi: 10.1007/s11060-012-1014-1. Epub 2012 Dec 7.


Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats.

Huo T, Barth RF, Yang W, Nakkula RJ, Koynova R, Tenchov B, Chaudhury AR, Agius L, Boulikas T, Elleaume H, Lee RJ.

PLoS One. 2012;7(11):e48752. doi: 10.1371/journal.pone.0048752. Epub 2012 Nov 13.


A poly(glycerol-sebacate-curcumin) polymer with potential use for brain gliomas.

Sun ZJ, Sun B, Tao RB, Xie X, Lu XL, Dong DL.

J Biomed Mater Res A. 2013 Jan;101(1):253-60. doi: 10.1002/jbm.a.34319. Epub 2012 Aug 31.


Intracranial MEMS based temozolomide delivery in a 9L rat gliosarcoma model.

Masi BC, Tyler BM, Bow H, Wicks RT, Xue Y, Brem H, Langer R, Cima MJ.

Biomaterials. 2012 Aug;33(23):5768-75. doi: 10.1016/j.biomaterials.2012.04.048. Epub 2012 May 14.

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