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Endoplasmic reticulum-associated degradation is required for cold adaptation and regulation of sterol biosynthesis in the yeast Saccharomyces cerevisiae.

Loertscher J, Larson LL, Matson CK, Parrish ML, Felthauser A, Sturm A, Tachibana C, Bard M, Wright R.

Eukaryot Cell. 2006 Apr;5(4):712-22.


Membrane and soluble substrates of the Doa10 ubiquitin ligase are degraded by distinct pathways.

Ravid T, Kreft SG, Hochstrasser M.

EMBO J. 2006 Feb 8;25(3):533-43. Epub 2006 Jan 26.


Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast.

Theesfeld CL, Hampton RY.

J Biol Chem. 2013 Mar 22;288(12):8519-30. doi: 10.1074/jbc.M112.404517. Epub 2013 Jan 10.


An unusual transmembrane helix in the endoplasmic reticulum ubiquitin ligase Doa10 modulates degradation of its cognate E2 enzyme.

Kreft SG, Hochstrasser M.

J Biol Chem. 2011 Jun 10;286(23):20163-74. doi: 10.1074/jbc.M110.196360. Epub 2011 Apr 5.


Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.


Membrane-associated ubiquitin ligase complex containing gp78 mediates sterol-accelerated degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

Jo Y, Sguigna PV, DeBose-Boyd RA.

J Biol Chem. 2011 Apr 29;286(17):15022-31. doi: 10.1074/jbc.M110.211326. Epub 2011 Feb 22.


The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.

Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY.

J Biol Chem. 2011 Jul 29;286(30):26298-307. doi: 10.1074/jbc.M111.244798. Epub 2011 May 31.


Sec61p-independent degradation of the tail-anchored ER membrane protein Ubc6p.

Walter J, Urban J, Volkwein C, Sommer T.

EMBO J. 2001 Jun 15;20(12):3124-31.


Atypical ubiquitylation in yeast targets lysine-less Asi2 for proteasomal degradation.

Boban M, Ljungdahl PO, Foisner R.

J Biol Chem. 2015 Jan 23;290(4):2489-95. doi: 10.1074/jbc.M114.600593. Epub 2014 Dec 9.


Degradation of sterol regulatory element-binding protein precursor requires the endoplasmic reticulum-associated degradation components Ubc7 and Hrd1 in fission yeast.

Hughes BT, Nwosu CC, Espenshade PJ.

J Biol Chem. 2009 Jul 31;284(31):20512-21. doi: 10.1074/jbc.M109.002436. Epub 2009 Jun 11.


Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY.

Nat Cell Biol. 2001 Jan;3(1):24-9.


N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.

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