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Items: 1 to 20 of 112

1.

High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.

Bender A, Krishnan KJ, Morris CM, Taylor GA, Reeve AK, Perry RH, Jaros E, Hersheson JS, Betts J, Klopstock T, Taylor RW, Turnbull DM.

Nat Genet. 2006 May;38(5):515-7. Epub 2006 Apr 9.

PMID:
16604074
2.

Mitochondrial DNA deletions in mice in men: substantia nigra is much less affected in the mouse.

Guo X, Kudryavtseva E, Bodyak N, Nicholas A, Dombrovsky I, Yang D, Kraytsberg Y, Simon DK, Khrapko K.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1159-62. doi: 10.1016/j.bbabio.2010.04.005. Epub 2010 Apr 11.

3.

Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms.

Perier C, Bender A, García-Arumí E, Melià MJ, Bové J, Laub C, Klopstock T, Elstner M, Mounsey RB, Teismann P, Prolla T, Andreu AL, Vila M.

Brain. 2013 Aug;136(Pt 8):2369-78. doi: 10.1093/brain/awt196.

4.

Detrimental deletions: mitochondria, aging and Parkinson's disease.

Biskup S, Moore DJ.

Bioessays. 2006 Oct;28(10):963-7. Review.

PMID:
16998822
5.

Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons.

Kraytsberg Y, Kudryavtseva E, McKee AC, Geula C, Kowall NW, Khrapko K.

Nat Genet. 2006 May;38(5):518-20. Epub 2006 Apr 9.

PMID:
16604072
6.

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease.

Simon DK, Lin MT, Zheng L, Liu GJ, Ahn CH, Kim LM, Mauck WM, Twu F, Beal MF, Johns DR.

Neurobiol Aging. 2004 Jan;25(1):71-81.

PMID:
14675733
7.

The low abundance of clonally expanded mitochondrial DNA point mutations in aged substantia nigra neurons.

Reeve AK, Krishnan KJ, Taylor G, Elson JL, Bender A, Taylor RW, Morris CM, Turnbull DM.

Aging Cell. 2009 Aug;8(4):496-8. doi: 10.1111/j.1474-9726.2009.00492.x. Epub 2009 May 31.

8.

Nature of mitochondrial DNA deletions in substantia nigra neurons.

Reeve AK, Krishnan KJ, Elson JL, Morris CM, Bender A, Lightowlers RN, Turnbull DM.

Am J Hum Genet. 2008 Jan;82(1):228-35. doi: 10.1016/j.ajhg.2007.09.018.

9.

Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders.

Gu G, Reyes PE, Golden GT, Woltjer RL, Hulette C, Montine TJ, Zhang J.

J Neuropathol Exp Neurol. 2002 Jul;61(7):634-9.

10.

The 'common deletion' is not increased in parkinsonian substantia nigra as shown by competitive polymerase chain reaction.

Kösel S, Egensperger R, Schnopp NM, Graeber MB.

Mov Disord. 1997 Sep;12(5):639-45.

PMID:
9380043
11.

Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat.

Parkinson GM, Dayas CV, Smith DW.

Curr Aging Sci. 2014;7(3):155-60.

PMID:
25612740
12.

Dopaminergic midbrain neurons are the prime target for mitochondrial DNA deletions.

Bender A, Schwarzkopf RM, McMillan A, Krishnan KJ, Rieder G, Neumann M, Elstner M, Turnbull DM, Klopstock T.

J Neurol. 2008 Aug;255(8):1231-5. doi: 10.1007/s00415-008-0892-9. Epub 2008 Jul 11.

PMID:
18604467
13.

Quantitation of a mitochondrial DNA deletion in Parkinson's disease.

Mann VM, Cooper JM, Schapira AH.

FEBS Lett. 1992 Mar 16;299(3):218-22.

14.

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence.

Ikebe S, Tanaka M, Ohno K, Sato W, Hattori K, Kondo T, Mizuno Y, Ozawa T.

Biochem Biophys Res Commun. 1990 Aug 16;170(3):1044-8.

PMID:
2390073
15.

Mitochondrial DNA mutations in aging.

Khrapko K, Turnbull D.

Prog Mol Biol Transl Sci. 2014;127:29-62. doi: 10.1016/B978-0-12-394625-6.00002-7. Review.

PMID:
25149213
16.

Mitochondrial DNA polymorphism in substantia nigra.

Kapsa RM, Jean-Francois MJ, Lertrit P, Weng S, Siregar N, Ojaimi J, Donnan G, Masters C, Byrne E.

J Neurol Sci. 1996 Dec;144(1-2):204-11.

PMID:
8994125
17.

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age.

Corral-Debrinski M, Horton T, Lott MT, Shoffner JM, Beal MF, Wallace DC.

Nat Genet. 1992 Dec;2(4):324-9.

PMID:
1303288
18.

Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

Kadenbach B, Münscher C, Frank V, Müller-Höcker J, Napiwotzki J.

Mutat Res. 1995 Oct;338(1-6):161-72. Review.

PMID:
7565871
19.

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases.

Ozawa T.

Biochim Biophys Acta. 1995 May 24;1271(1):177-89. Review.

PMID:
7599206
20.

Point mutations of mitochondrial genome in Parkinson's disease.

Ikebe S, Tanaka M, Ozawa T.

Brain Res Mol Brain Res. 1995 Feb;28(2):281-95.

PMID:
7723627
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