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Results: 1 to 20 of 412

1.

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H.

J Neurosci. 2006 Apr 5;26(14):3845-54.

PMID:
16597739
[PubMed - indexed for MEDLINE]
Free Article
2.

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.

Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR.

Hum Mol Genet. 2004 Jan 15;13(2):159-70. Epub 2003 Nov 25.

PMID:
14645205
[PubMed - indexed for MEDLINE]
Free Article
3.

Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice.

Dewachter I, Reversé D, Caluwaerts N, Ris L, Kuipéri C, Van den Haute C, Spittaels K, Umans L, Serneels L, Thiry E, Moechars D, Mercken M, Godaux E, Van Leuven F.

J Neurosci. 2002 May 1;22(9):3445-53.

PMID:
11978821
[PubMed - indexed for MEDLINE]
Free Article
4.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

PMID:
16405513
[PubMed - indexed for MEDLINE]
5.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
[PubMed - indexed for MEDLINE]
6.

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Knappenberger KS, Tian G, Ye X, Sobotka-Briner C, Ghanekar SV, Greenberg BD, Scott CW.

Biochemistry. 2004 May 25;43(20):6208-18.

PMID:
15147205
[PubMed - indexed for MEDLINE]
7.

Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase.

Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O.

J Biol Chem. 2005 Jul 22;280(29):27303-9. Epub 2005 May 25.

PMID:
15917251
[PubMed - indexed for MEDLINE]
Free Article
8.

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.

Nature. 1999 Apr 8;398(6727):513-7.

PMID:
10206644
[PubMed - indexed for MEDLINE]
9.

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C.

J Biol Chem. 2002 Nov 22;277(47):44754-9. Epub 2002 Sep 9.

PMID:
12223485
[PubMed - indexed for MEDLINE]
Free Article
10.

Failure of the interaction between presenilin 1 and the substrate of gamma-secretase to produce Abeta in insect cells.

Pitsi D, Kienlen-Campard P, Octave JN.

J Neurochem. 2002 Oct;83(2):390-9.

PMID:
12423249
[PubMed - indexed for MEDLINE]
11.

Proteolytic processing of the Alzheimer's disease amyloid precursor protein in brain and platelets.

Evin G, Zhu A, Holsinger RM, Masters CL, Li QX.

J Neurosci Res. 2003 Nov 1;74(3):386-92.

PMID:
14598315
[PubMed - indexed for MEDLINE]
12.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
[PubMed - indexed for MEDLINE]
13.

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.

J Neurochem. 2006 Jan;96(1):118-25. Epub 2005 Nov 21.

PMID:
16300640
[PubMed - indexed for MEDLINE]
14.

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.

Nature. 2000 Jun 8;405(6787):689-94.

PMID:
10864326
[PubMed - indexed for MEDLINE]
15.

Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Czirr E, Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.

J Biol Chem. 2007 Aug 24;282(34):24504-13. Epub 2007 Jun 15.

PMID:
17573346
[PubMed - indexed for MEDLINE]
Free Article
16.

Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity.

Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM.

J Neurochem. 2005 Sep;94(5):1315-28. Epub 2005 Jul 7.

PMID:
16001967
[PubMed - indexed for MEDLINE]
17.

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
[PubMed - indexed for MEDLINE]
18.

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM.

J Biol Chem. 2003 Jun 20;278(25):22475-81. Epub 2003 Apr 8.

PMID:
12684521
[PubMed - indexed for MEDLINE]
Free Article
19.

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.

J Biol Chem. 2002 Sep 27;277(39):36521-6. Epub 2002 Jul 15.

PMID:
12119298
[PubMed - indexed for MEDLINE]
Free Article
20.

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.

Wiley JC, Hudson M, Kanning KC, Schecterson LC, Bothwell M.

J Neurochem. 2005 Sep;94(5):1189-201. Epub 2005 Jun 30.

PMID:
15992373
[PubMed - indexed for MEDLINE]

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