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Results: 1 to 20 of 114

1.

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Mahley RW, Weisgraber KH, Huang Y.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5644-51. Epub 2006 Mar 27. Review.

PMID:
16567625
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology.

Mahley RW, Huang Y.

Acta Neurol Scand Suppl. 2006;185:8-14. Review.

PMID:
16866905
[PubMed - indexed for MEDLINE]
3.

Apolipoprotein e sets the stage: response to injury triggers neuropathology.

Mahley RW, Huang Y.

Neuron. 2012 Dec 6;76(5):871-85. doi: 10.1016/j.neuron.2012.11.020. Review.

PMID:
23217737
[PubMed - indexed for MEDLINE]
Free Article
4.

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

Aleshkov S, Abraham CR, Zannis VI.

Biochemistry. 1997 Aug 26;36(34):10571-80.

PMID:
9265639
[PubMed - indexed for MEDLINE]
5.

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

Brecht WJ, Harris FM, Chang S, Tesseur I, Yu GQ, Xu Q, Dee Fish J, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y.

J Neurosci. 2004 Mar 10;24(10):2527-34.

PMID:
15014128
[PubMed - indexed for MEDLINE]
Free Article
6.

Apolipoprotein (apo) E4 enhances amyloid beta peptide production in cultured neuronal cells: apoE structure as a potential therapeutic target.

Ye S, Huang Y, Müllendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW.

Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18700-5. Epub 2005 Dec 12.

PMID:
16344478
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

The pathological cross talk between apolipoprotein E and amyloid-beta peptide in Alzheimer's disease: emerging gene-based therapeutic approaches.

Iurescia S, Fioretti D, Mangialasche F, Rinaldi M.

J Alzheimers Dis. 2010;21(1):35-48. doi: 10.3233/JAD-2010-100009. Review.

PMID:
20182014
[PubMed - indexed for MEDLINE]
8.

Detrimental effects of apolipoprotein E4: potential therapeutic targets in Alzheimer's disease.

Mahley RW, Huang Y, Weisgraber KH.

Curr Alzheimer Res. 2007 Dec;4(5):537-40. Review.

PMID:
18220516
[PubMed - indexed for MEDLINE]
9.

Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.

Chen HK, Ji ZS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Y, Mahley RW.

J Biol Chem. 2011 Feb 18;286(7):5215-21. doi: 10.1074/jbc.M110.151084. Epub 2010 Nov 30.

PMID:
21118811
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

Morrow JA, Hatters DM, Lu B, Hochtl P, Oberg KA, Rupp B, Weisgraber KH.

J Biol Chem. 2002 Dec 27;277(52):50380-5. Epub 2002 Oct 21.

PMID:
12393895
[PubMed - indexed for MEDLINE]
Free Article
11.

Mechanisms linking apolipoprotein E isoforms with cardiovascular and neurological diseases.

Huang Y.

Curr Opin Lipidol. 2010 Aug;21(4):337-45. doi: 10.1097/MOL.0b013e32833af368. Review.

PMID:
20531185
[PubMed - indexed for MEDLINE]
12.

Apolipoprotein E isoforms in Alzheimer's disease pathology and etiology.

Baum L, Chen L, Ng HK, Pang CP.

Microsc Res Tech. 2000 Aug 15;50(4):278-81. Review.

PMID:
10936880
[PubMed - indexed for MEDLINE]
13.

APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.

Colton CA, Brown CM, Cook D, Needham LK, Xu Q, Czapiga M, Saunders AM, Schmechel DE, Rasheed K, Vitek MP.

Neurobiol Aging. 2002 Sep-Oct;23(5):777-85.

PMID:
12392781
[PubMed - indexed for MEDLINE]
14.

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients.

Ji Y, Gong Y, Gan W, Beach T, Holtzman DM, Wisniewski T.

Neuroscience. 2003;122(2):305-15.

PMID:
14614898
[PubMed - indexed for MEDLINE]
15.

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.

Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD, et al.

J Clin Invest. 1994 Aug;94(2):860-9.

PMID:
8040342
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.

Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L.

J Neurosci. 2002 Dec 15;22(24):10539-48.

PMID:
12486146
[PubMed - indexed for MEDLINE]
Free Article
17.

A dual role for apolipoprotein e in neuroinflammation: anti- and pro-inflammatory activity.

Guo L, LaDu MJ, Van Eldik LJ.

J Mol Neurosci. 2004;23(3):205-12.

PMID:
15181248
[PubMed - indexed for MEDLINE]
18.

Apolipoprotein E. Structure, function, and possible roles in Alzheimer's disease.

Mahley RW, Nathan BP, Pitas RE.

Ann N Y Acad Sci. 1996 Jan 17;777:139-45. Review.

PMID:
8624076
[PubMed - indexed for MEDLINE]
19.

Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration.

Ji ZS, Müllendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW.

J Biol Chem. 2006 Feb 3;281(5):2683-92. Epub 2005 Nov 17.

PMID:
16298992
[PubMed - indexed for MEDLINE]
Free Article
20.

Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E.

Raffai RL, Dong LM, Farese RV Jr, Weisgraber KH.

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11587-91. Epub 2001 Sep 11.

PMID:
11553788
[PubMed - indexed for MEDLINE]
Free PMC Article

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