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Adenosine and inflammation: CD39 and CD73 are critical mediators in LPS-induced PMN trafficking into the lungs.

Reutershan J, Vollmer I, Stark S, Wagner R, Ngamsri KC, Eltzschig HK.

FASEB J. 2009 Feb;23(2):473-82. doi: 10.1096/fj.08-119701. Epub 2008 Oct 6.


Protective role of ecto-5'-nucleotidase (CD73) in renal ischemia.

Grenz A, Zhang H, Eckle T, Mittelbronn M, Wehrmann M, Köhle C, Kloor D, Thompson LF, Osswald H, Eltzschig HK.

J Am Soc Nephrol. 2007 Mar;18(3):833-45. Epub 2007 Jan 31.


Allergen-induced airway hyperresponsiveness is absent in ecto-5'-nucleotidase (CD73)-deficient mice.

Schreiber R, Castrop H, Kunzelmann K.

Pflugers Arch. 2008 Nov;457(2):431-40. doi: 10.1007/s00424-008-0543-0. Epub 2008 Jul 8.


Extracellular adenosine production by ecto-5'-nucleotidase protects during murine hepatic ischemic preconditioning.

Hart ML, Much C, Gorzolla IC, Schittenhelm J, Kloor D, Stahl GL, Eltzschig HK.

Gastroenterology. 2008 Nov;135(5):1739-1750.e3. doi: 10.1053/j.gastro.2008.07.064. Epub 2008 Aug 3.


Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis.

Fernández P, Perez-Aso M, Smith G, Wilder T, Trzaska S, Chiriboga L, Franks A Jr, Robson SC, Cronstein BN, Chan ES.

Am J Pathol. 2013 Dec;183(6):1740-6. doi: 10.1016/j.ajpath.2013.08.024.


Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury.

Eckle T, Füllbier L, Wehrmann M, Khoury J, Mittelbronn M, Ibla J, Rosenberger P, Eltzschig HK.

J Immunol. 2007 Jun 15;178(12):8127-37.


Ecto-5'-nucleotidase (CD73)-mediated extracellular adenosine production plays a critical role in hepatic fibrosis.

Peng Z, Fernandez P, Wilder T, Yee H, Chiriboga L, Chan ES, Cronstein BN.

Nucleosides Nucleotides Nucleic Acids. 2008 Jun;27(6):821-4. doi: 10.1080/15257770802146403. Review.


Role of extracellular nucleotide phosphohydrolysis in intestinal ischemia-reperfusion injury.

Hart ML, Henn M, Köhler D, Kloor D, Mittelbronn M, Gorzolla IC, Stahl GL, Eltzschig HK.

FASEB J. 2008 Aug;22(8):2784-97. doi: 10.1096/fj.07-103911. Epub 2008 Mar 19.


IFN-alpha induced adenosine production on the endothelium: a mechanism mediated by CD73 (ecto-5'-nucleotidase) up-regulation.

Niemelä J, Henttinen T, Yegutkin GG, Airas L, Kujari AM, Rajala P, Jalkanen S.

J Immunol. 2004 Feb 1;172(3):1646-53.


CD73-dependent regulation of interferon αA and interleukin-10 in the inflamed mucosa.

Sotnikov I, Louis NA.

ScientificWorldJournal. 2010 Nov 4;10:2167-80. doi: 10.1100/tsw.2010.203. Review.


Cardioprotection by ecto-5'-nucleotidase (CD73) and A2B adenosine receptors.

Eckle T, Krahn T, Grenz A, Köhler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK.

Circulation. 2007 Mar 27;115(12):1581-90. Epub 2007 Mar 12.


Targeted disruption of cd73/ecto-5'-nucleotidase alters thromboregulation and augments vascular inflammatory response.

Koszalka P, Ozüyaman B, Huo Y, Zernecke A, Flögel U, Braun N, Buchheiser A, Decking UK, Smith ML, Sévigny J, Gear A, Weber AA, Molojavyi A, Ding Z, Weber C, Ley K, Zimmermann H, Gödecke A, Schrader J.

Circ Res. 2004 Oct 15;95(8):814-21. Epub 2004 Sep 9.


Adenosine produced via the CD73/ecto-5'-nucleotidase pathway has no impact on erythropoietin production but is associated with reduced kidney weight.

Ozüyaman B, Ding Z, Buchheiser A, Koszalka P, Braun N, Gödecke A, Decking UK, Zimmermann H, Schrader J.

Pflugers Arch. 2006 Jun;452(3):324-31. Epub 2006 Feb 9.


Ecto-5'-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line.

Andrade CM, Lopez PL, Noronha BT, Wink MR, Borojevic R, Margis R, Lenz G, Battastini AM, Guma FC.

Cell Tissue Res. 2011 May;344(2):279-86. doi: 10.1007/s00441-011-1140-7. Epub 2011 Mar 19.


Activity and expression of ecto-5'-nucleotidase/CD73 are increased by thyroid hormones in vascular smooth muscle cells.

Tamajusuku AS, Carrillo-Sepúlveda MA, Braganhol E, Wink MR, Sarkis JJ, Barreto-Chaves ML, Battastini AM.

Mol Cell Biochem. 2006 Sep;289(1-2):65-72. Epub 2006 May 23.


Activity and expression of ecto-5'-nucleotidase/CD73 are increased during phenotype conversion of a hepatic stellate cell line.

Andrade CM, Roesch GC, Wink MR, Guimarães EL, Souza LF, Jardim FR, Guaragna RM, Bernard EA, Margis R, Borojevic R, Battastini AM, Guma FC.

Life Sci. 2008 Jan 2;82(1-2):21-9. Epub 2007 Oct 23.


Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury.

Sun CX, Zhong H, Mohsenin A, Morschl E, Chunn JL, Molina JG, Belardinelli L, Zeng D, Blackburn MR.

J Clin Invest. 2006 Aug;116(8):2173-2182.


Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells.

Romio M, Reinbeck B, Bongardt S, Hüls S, Burghoff S, Schrader J.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C530-9. doi: 10.1152/ajpcell.00385.2010. Epub 2011 May 18.

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