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Items: 1 to 20 of 620

1.

Structural requirements of acetylcholinesterase reactivators.

Kuca K, Juna D, Musilek K.

Mini Rev Med Chem. 2006 Mar;6(3):269-77. Review.

PMID:
16515465
2.

Reactivators of acetylcholinesterase inhibited by organophosphorus nerve agents.

Mercey G, Verdelet T, Renou J, Kliachyna M, Baati R, Nachon F, Jean L, Renard PY.

Acc Chem Res. 2012 May 15;45(5):756-66. doi: 10.1021/ar2002864. Epub 2012 Feb 23.

PMID:
22360473
3.

In silico pharmacophore model for tabun-inhibited acetylcholinesterase reactivators: a study of their stereoelectronic properties.

Bhattacharjee AK, Kuca K, Musilek K, Gordon RK.

Chem Res Toxicol. 2010 Jan;23(1):26-36. doi: 10.1021/tx900192u.

PMID:
20028185
4.

New group of xylene linker-containing acetylcholinesterase reactivators as antidotes against the nerve agent cyclosarin.

Hrabinova M, Musilek K, Jun D, Kuca K.

J Enzyme Inhib Med Chem. 2006 Oct;21(5):515-9.

PMID:
17194020
5.

New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications.

Kuca K, Bartosová L, Jun D, Patocka J, Cabal J, Kassa J, Kunesová G.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Jun;149(1):75-82.

PMID:
16170392
6.

Potency of several oximes to reactivate human acetylcholinesterase and butyrylcholinesterase inhibited by paraoxon in vitro.

Jun D, Musilova L, Kuca K, Kassa J, Bajgar J.

Chem Biol Interact. 2008 Sep 25;175(1-3):421-4. doi: 10.1016/j.cbi.2008.05.004. Epub 2008 May 7.

PMID:
18617161
7.
8.

Evaluation of nine oximes on in vivo reactivation of blood, brain, and tissue cholinesterase activity inhibited by organophosphorus nerve agents at lethal dose.

Shih TM, Skovira JW, O'Donnell JC, McDonough JH.

Toxicol Mech Methods. 2009 Sep;19(6-7):386-400. doi: 10.1080/15376510903213892.

PMID:
19778239
9.

Unequal efficacy of pyridinium oximes in acute organophosphate poisoning.

Antonijevic B, Stojiljkovic MP.

Clin Med Res. 2007 Mar;5(1):71-82. Review.

PMID:
17456837
10.

Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?

Aurbek N, Herkert NM, Koller M, Thiermann H, Worek F.

Chem Biol Interact. 2010 Sep 6;187(1-3):215-9. doi: 10.1016/j.cbi.2010.01.035. Epub 2010 Jan 25.

PMID:
20105433
11.

Russian VX: inhibition and reactivation of acetylcholinesterase compared with VX agent.

Kuca K, Jun D, Cabal J, Hrabinova M, Bartosova L, Opletalova V.

Basic Clin Pharmacol Toxicol. 2006 Apr;98(4):389-94.

PMID:
16623863
12.

The development of new oximes and the evaluation of their reactivating, therapeutic and neuroprotective efficacy against tabun.

Kassa J, Kuca K, Karasova J, Musilek K.

Mini Rev Med Chem. 2008 Oct;8(11):1134-43. Review.

PMID:
18855728
14.

Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.

Kuca K, Musilek K, Jun D, Pohanka M, Ghosh KK, Hrabinova M.

J Enzyme Inhib Med Chem. 2010 Aug;25(4):509-12. doi: 10.3109/14756360903357569.

PMID:
20192902
15.
16.

Cholinesterase reactivators: the fate and effects in the organism poisoned with organophosphates/nerve agents.

Bajgar J, Kuca K, Jun D, Bartosova L, Fusek J.

Curr Drug Metab. 2007 Dec;8(8):803-9.

PMID:
18220560
17.
18.

In vitro and in vivo evaluation of pyridinium oximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.

Calić M, Vrdoljak AL, Radić B, Jelić D, Jun D, Kuca K, Kovarik Z.

Toxicology. 2006 Feb 15;219(1-3):85-96. Epub 2005 Dec 5.

PMID:
16332406
19.

Potency of novel oximes to reactivate sarin inhibited human cholinesterases.

Jun D, Kuca K, Picha J, Koleckar V, Marek J.

Drug Chem Toxicol. 2008;31(1):1-9.

PMID:
18161504
20.

Y124 at the peripheral anionic site is important for the reactivation of nerve agent-inhibited acetylcholinesterase by H oximes.

Luo C, Chambers C, Pattabiraman N, Tong M, Tipparaju P, Saxena A.

Biochem Pharmacol. 2010 Nov 1;80(9):1427-36. doi: 10.1016/j.bcp.2010.07.020. Epub 2010 Jul 22.

PMID:
20655881
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