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Results: 1 to 20 of 115

Similar articles for PubMed (Select 16507543)

1.

Characterization of the inflammatory response to a highly selective PDE4 inhibitor in the rat and the identification of biomarkers that correlate with toxicity.

Dietsch GN, Dipalma CR, Eyre RJ, Pham TQ, Poole KM, Pefaur NB, Welch WD, Trueblood E, Kerns WD, Kanaly ST.

Toxicol Pathol. 2006;34(1):39-51.

2.

Altered gene expression in rat mesenteric tissue following in vivo exposure to a phosphodiesterase 4 inhibitor.

Daguès N, Pawlowski V, Guigon G, Ledieu D, Sobry C, Hanton G, Freslon JL, Chevalier S.

Toxicol Appl Pharmacol. 2007 Jan 1;218(1):52-63. Epub 2006 Oct 27.

PMID:
17157341
3.

Mesenteritis precedes vasculitis in the rat mesentery after subacute administration of a phosphodiesterase type 4 inhibitor.

Mecklenburg L, Heuser A, Juengling T, Kohler M, Foell R, Ockert D, Tuch K, Bode G.

Toxicol Lett. 2006 May 5;163(1):54-64. Epub 2005 Oct 24.

PMID:
16246509
4.

Concentration-dependent roles for heparin in modifying lipopolysaccharide-induced activation of mononuclear cells in whole blood.

Hochart H, Jenkins PV, Preston RJ, Smith OP, White B, O'Donnell J.

Thromb Haemost. 2008 Mar;99(3):570-5. doi: 10.1160/TH07-06-0424.

PMID:
18327406
5.

Characterisation of the vascular and inflammatory lesions induced by the PDE4 inhibitor CI-1044 in the dog.

Hanton G, Sobry C, Daguès N, Provost JP, Le Net JL, Comby P, Chevalier S.

Toxicol Lett. 2008 Jun 10;179(1):15-22. doi: 10.1016/j.toxlet.2008.03.009. Epub 2008 Mar 25.

PMID:
18485625
6.
7.

Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats.

Slim RM, Robertson DG, Albassam M, Reily MD, Robosky L, Dethloff LA.

Toxicol Appl Pharmacol. 2002 Sep 1;183(2):108-9.

PMID:
12387750
8.

Erythropoietin attenuates lipopolysaccharide-induced white matter injury in the neonatal rat brain.

Kumral A, Baskin H, Yesilirmak DC, Ergur BU, Aykan S, Genc S, Genc K, Yilmaz O, Tugyan K, Giray O, Duman N, Ozkan H.

Neonatology. 2007;92(4):269-78. Epub 2007 Jul 11.

PMID:
17627093
9.

Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker.

Daguès N, Pawlowski V, Sobry C, Hanton G, Borde F, Soler S, Freslon JL, Chevalier S.

Toxicol Sci. 2007 Nov;100(1):238-47. Epub 2007 Jun 14.

10.

Effects of ciclamilast, a new PDE 4 PDE4 inhibitor, on airway hyperresponsiveness, PDE4D expression and airway inflammation in a murine model of asthma.

Deng YM, Xie QM, Tang HF, Sun JG, Deng JF, Chen JQ, Yang SY.

Eur J Pharmacol. 2006 Oct 10;547(1-3):125-35. Epub 2006 Jul 13.

PMID:
16956605
12.

Pharmacology of a novel, orally active PDE4 inhibitor.

Dastidar SG, Ray A, Shirumalla R, Rajagopal D, Chaudhary S, Nanda K, Sharma P, Seth MK, Balachandran S, Gupta N, Palle V.

Pharmacology. 2009;83(5):275-86. doi: 10.1159/000209608. Epub 2009 Mar 25.

PMID:
19321962
13.

Phosphodiesterase type 4 inhibitors cause proinflammatory effects in vivo.

McCluskie K, Klein U, Linnevers C, Ji YH, Yang A, Husfeld C, Thomas GR.

J Pharmacol Exp Ther. 2006 Oct;319(1):468-76. Epub 2006 Jul 21.

14.
15.

Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10, when cells in whole blood were stimulated with lipopolysaccharide.

Shannon E, Noveck R, Sandoval F, Kamath B.

Immunopharmacol Immunotoxicol. 2008;30(3):447-57. doi: 10.1080/08923970802135161 .

PMID:
18668392
16.

Differential inflammatory status in rats susceptible or resistant to diet-induced obesity: effects of EPA ethyl ester treatment.

Pérez-Echarri N, Pérez-Matute P, Marcos-Gómez B, Baena MJ, Marti A, Martínez JA, Moreno-Aliaga MJ.

Eur J Nutr. 2008 Oct;47(7):380-6. doi: 10.1007/s00394-008-0738-3. Epub 2008 Sep 18.

PMID:
18807107
17.

Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation.

Hope HR, Anderson GD, Burnette BL, Compton RP, Devraj RV, Hirsch JL, Keith RH, Li X, Mbalaviele G, Messing DM, Saabye MJ, Schindler JF, Selness SR, Stillwell LI, Webb EG, Zhang J, Monahan JB.

J Pharmacol Exp Ther. 2009 Dec;331(3):882-95. doi: 10.1124/jpet.109.158329. Epub 2009 Aug 31.

18.

Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385.

Weaver JL, Snyder R, Knapton A, Herman EH, Honchel R, Miller T, Espandiari P, Smith R, Gu YZ, Goodsaid FM, Rosenblum IY, Sistare FD, Zhang J, Hanig J.

Toxicol Pathol. 2008 Oct;36(6):840-9. doi: 10.1177/0192623308322310. Epub 2008 Sep 5.

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