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Items: 1 to 20 of 478


eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay.

Shibuya T, Tange TØ, Sonenberg N, Moore MJ.

Nat Struct Mol Biol. 2004 Apr;11(4):346-51. Epub 2004 Mar 21.


Human spliceosomal protein CWC22 plays a role in coupling splicing to exon junction complex deposition and nonsense-mediated decay.

Alexandrov A, Colognori D, Shu MD, Steitz JA.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):21313-8. doi: 10.1073/pnas.1219725110. Epub 2012 Dec 10.


The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity.

Ballut L, Marchadier B, Baguet A, Tomasetto C, Séraphin B, Le Hir H.

Nat Struct Mol Biol. 2005 Oct;12(10):861-9. Epub 2005 Sep 18.


Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

Buchwald G, Ebert J, Basquin C, Sauliere J, Jayachandran U, Bono F, Le Hir H, Conti E.

Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10050-5. doi: 10.1073/pnas.1000993107. Epub 2010 May 17.


Mechanism of ATP turnover inhibition in the EJC.

Nielsen KH, Chamieh H, Andersen CB, Fredslund F, Hamborg K, Le Hir H, Andersen GR.

RNA. 2009 Jan;15(1):67-75. doi: 10.1261/rna.1283109. Epub 2008 Nov 25.


The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA.

Bono F, Ebert J, Lorentzen E, Conti E.

Cell. 2006 Aug 25;126(4):713-25.


Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA.

Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Séraphin B, Le Hir H, Andersen GR.

Science. 2006 Sep 29;313(5795):1968-72. Epub 2006 Aug 24.


An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay.

Palacios IM, Gatfield D, St Johnston D, Izaurralde E.

Nature. 2004 Feb 19;427(6976):753-7.


A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay.

Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, Reed R, Sonenberg N.

Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4118-23. Epub 2004 Mar 15.


Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly.

Barbosa I, Haque N, Fiorini F, Barrandon C, Tomasetto C, Blanchette M, Le Hir H.

Nat Struct Mol Biol. 2012 Oct;19(10):983-90. doi: 10.1038/nsmb.2380. Epub 2012 Sep 9.


Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module.

Degot S, Le Hir H, Alpy F, Kedinger V, Stoll I, Wendling C, Seraphin B, Rio MC, Tomasetto C.

J Biol Chem. 2004 Aug 6;279(32):33702-15. Epub 2004 May 27.


SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.

Kashima I, Jonas S, Jayachandran U, Buchwald G, Conti E, Lupas AN, Izaurralde E.

Genes Dev. 2010 Nov 1;24(21):2440-50. doi: 10.1101/gad.604610. Epub 2010 Oct 7.


Exon junction complex enhances translation of spliced mRNAs at multiple steps.

Lee HC, Choe J, Chi SG, Kim YK.

Biochem Biophys Res Commun. 2009 Jul 3;384(3):334-40. doi: 10.1016/j.bbrc.2009.04.123. Epub 2009 May 3.


The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.

Gehring NH, Lamprinaki S, Hentze MW, Kulozik AE.

PLoS Biol. 2009 May 26;7(5):e1000120. doi: 10.1371/journal.pbio.1000120. Epub 2009 May 26.


Structural insights into the exon junction complex.

Le Hir H, Andersen GR.

Curr Opin Struct Biol. 2008 Feb;18(1):112-9. doi: 10.1016/ Review.


Introns play an essential role in splicing-dependent formation of the exon junction complex.

Ideue T, Sasaki YT, Hagiwara M, Hirose T.

Genes Dev. 2007 Aug 15;21(16):1993-8. Epub 2007 Aug 3.


MLN51 stimulates the RNA-helicase activity of eIF4AIII.

Noble CG, Song H.

PLoS One. 2007 Mar 21;2(3):e303.

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