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Items: 1 to 20 of 99

1.

Transcriptional repression of interleukin-2 in human systemic lupus erythematosus.

Katsiari CG, Tsokos GC.

Autoimmun Rev. 2006 Feb;5(2):118-21. Epub 2005 Sep 26. Review.

PMID:
16431340
2.

Transcriptional regulation of interleukin 2 in SLE T cells.

Tenbrock K, Tsokos GC.

Int Rev Immunol. 2004 May-Aug;23(3-4):333-45. Review.

PMID:
15204092
3.
4.

Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalities.

Gómez-Martín D, Díaz-Zamudio M, Crispín JC, Alcocer-Varela J.

Autoimmun Rev. 2009 Sep;9(1):34-9. doi: 10.1016/j.autrev.2009.02.035. Epub 2009 Mar 6. Review.

PMID:
19269352
5.
6.

Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosus.

Solomou EE, Juang YT, Gourley MF, Kammer GM, Tsokos GC.

J Immunol. 2001 Mar 15;166(6):4216-22.

7.

Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity.

Herndon TM, Juang YT, Solomou EE, Rothwell SW, Gourley MF, Tsokos GC.

Clin Immunol. 2002 May;103(2):145-53.

PMID:
12027419
9.

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.

Juang YT, Wang Y, Solomou EE, Li Y, Mawrin C, Tenbrock K, Kyttaris VC, Tsokos GC.

J Clin Invest. 2005 Apr;115(4):996-1005.

10.

A novel intronic cAMP response element modulator (CREM) promoter is regulated by activator protein-1 (AP-1) and accounts for altered activation-induced CREM expression in T cells from patients with systemic lupus erythematosus.

Rauen T, Benedyk K, Juang YT, Kerkhoff C, Kyttaris VC, Roth J, Tsokos GC, Tenbrock K.

J Biol Chem. 2011 Sep 16;286(37):32366-72. doi: 10.1074/jbc.M111.245811. Epub 2011 Jul 13.

11.

cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.

Hedrich CM, Rauen T, Tsokos GC.

J Biol Chem. 2011 Dec 16;286(50):43429-36. doi: 10.1074/jbc.M111.299339. Epub 2011 Oct 5.

12.

Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus.

Fan W, Liang D, Tang Y, Qu B, Cui H, Luo X, Huang X, Chen S, Higgs BW, Jallal B, Yao Y, Harley JB, Shen N.

Arthritis Rheum. 2012 Nov;64(11):3715-25. doi: 10.1002/art.34596.

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15.

cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.

Hedrich CM, Crispin JC, Rauen T, Ioannidis C, Apostolidis SA, Lo MS, Kyttaris VC, Tsokos GC.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16606-11. doi: 10.1073/pnas.1210129109. Epub 2012 Sep 26.

16.

Decreased transcription of the human FCGR2B gene mediated by the -343 G/C promoter polymorphism and association with systemic lupus erythematosus.

Blank MC, Stefanescu RN, Masuda E, Marti F, King PD, Redecha PB, Wurzburger RJ, Peterson MG, Tanaka S, Pricop L.

Hum Genet. 2005 Jul;117(2-3):220-7. Epub 2005 May 14.

PMID:
15895258
17.

cAMP-responsive element modulator α (CREMα) contributes to decreased Notch-1 expression in T cells from patients with active systemic lupus erythematosus (SLE).

Rauen T, Grammatikos AP, Hedrich CM, Floege J, Tenbrock K, Ohl K, Kyttaris VC, Tsokos GC.

J Biol Chem. 2012 Dec 14;287(51):42525-32. doi: 10.1074/jbc.M112.425371. Epub 2012 Nov 2.

18.

cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus.

Rauen T, Hedrich CM, Juang YT, Tenbrock K, Tsokos GC.

J Biol Chem. 2011 Dec 16;286(50):43437-46. doi: 10.1074/jbc.M111.299313. Epub 2011 Oct 24.

19.

Estrogen upregulates cyclic AMP response element modulator α expression and downregulates interleukin-2 production by human T lymphocytes.

Moulton VR, Holcomb DR, Zajdel MC, Tsokos GC.

Mol Med. 2012 May 9;18:370-8. doi: 10.2119/molmed.2011.00506.

20.

Transcriptional and epigenetic regulation of interleukin-2 gene in activated T cells by morphine.

Wang J, Barke RA, Roy S.

J Biol Chem. 2007 Mar 9;282(10):7164-71. Epub 2007 Jan 16.

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