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p16Ink4a or p19Arf loss contributes to Tal1-induced leukemogenesis in mice.

Shank-Calvo JA, Draheim K, Bhasin M, Kelliher MA.

Oncogene. 2006 May 18;25(21):3023-31.


The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis.

D'Amico M, Wu K, Di Vizio D, Reutens AT, Stahl M, Fu M, Albanese C, Russell RG, Muller WJ, White M, Negassa A, Lee HW, DePinho RA, Pestell RG.

Cancer Res. 2003 Jun 15;63(12):3395-402.


Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages.

Randle DH, Zindy F, Sherr CJ, Roussel MF.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9654-9. Epub 2001 Jul 31.


The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements.

D'Amico M, Wu K, Fu M, Rao M, Albanese C, Russell RG, Lian H, Bregman D, White MA, Pestell RG.

Cancer Res. 2004 Jun 15;64(12):4122-30.


INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas.

Tannapfel A, Busse C, Weinans L, Benicke M, Katalinic A, Geissler F, Hauss J, Wittekind C.

Oncogene. 2001 Oct 25;20(48):7104-9.


p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.

Fasseu M, Aplan PD, Chopin M, Boissel N, Bories JC, Soulier J, von Boehmer H, Sigaux F, Regnault A.

Blood. 2007 Oct 1;110(7):2610-9. Epub 2007 May 16.


The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis.

Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA.

Oncogene. 2004 Jan 15;23(2):379-85.


p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.

Radfar A, Unnikrishnan I, Lee HW, DePinho RA, Rosenberg N.

Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13194-9.


p16(Ink4a) interferes with Abelson virus transformation by enhancing apoptosis.

Sachs Z, Sharpless NE, DePinho RA, Rosenberg N.

J Virol. 2004 Apr;78(7):3304-11.


Relationship between alterations of p16(INK4a) and p14(ARF) genes of CDKN2A locus and gastric carcinogenesis.

Tang S, Luo H, Yu J, Yang D, Shu J.

Chin Med J (Engl). 2003 Jul;116(7):1083-7.


Consistent inactivation of p19(Arf) but not p15(Ink4b) in murine myeloid cells transformed in vivo by deregulated c-Myc.

Haviernik P, Schmidt M, Hu X, Wolff L.

Oncogene. 2003 Mar 20;22(11):1600-10.


Inactivation of the INK4a/ARF locus and p53 in sporadic extrahepatic bile duct cancers and bile tract cancer cell lines.

Caca K, Feisthammel J, Klee K, Tannapfel A, Witzigmann H, Wittekind C, Mössner J, Berr F.

Int J Cancer. 2002 Feb 1;97(4):481-8.


p16 is a major inactivation target in hepatocellular carcinoma.

Jin M, Piao Z, Kim NG, Park C, Shin EC, Park JH, Jung HJ, Kim CG, Kim H.

Cancer. 2000 Jul 1;89(1):60-8.


INK4a/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene.

Pinyol M, Hernández L, Martínez A, Cobo F, Hernández S, Beà S, López-Guillermo A, Nayach I, Palacín A, Nadal A, Fernández PL, Montserrat E, Cardesa A, Campo E.

Am J Pathol. 2000 Jun;156(6):1987-96.


Definition of three minimal deleted regions by comprehensive allelotyping and mutational screening of FHIT,p16(INK4A), and p19(ARF) genes in nasopharyngeal carcinoma.

Ko JY, Lee TC, Hsiao CF, Lin GL, Yen SH, Chen KY, Hsiung CA, Chen PJ, Hsu MM, Jou YS.

Cancer. 2002 Apr 1;94(7):1987-96.


Mutational analysis of selected genes in the TGFbeta, Wnt, pRb, and p53 pathways in primary uveal melanoma.

Edmunds SC, Kelsell DP, Hungerford JL, Cree IA.

Invest Ophthalmol Vis Sci. 2002 Sep;43(9):2845-51.


Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52. Epub 2006 Apr 3.

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