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Items: 1 to 20 of 107

1.

The slow Wallerian degeneration protein, WldS, binds directly to VCP/p97 and partially redistributes it within the nucleus.

Laser H, Conforti L, Morreale G, Mack TG, Heyer M, Haley JE, Wishart TM, Beirowski B, Walker SA, Haase G, Celik A, Adalbert R, Wagner D, Grumme D, Ribchester RR, Plomann M, Coleman MP.

Mol Biol Cell. 2006 Mar;17(3):1075-84. Epub 2005 Dec 21.

2.

VCP binding influences intracellular distribution of the slow Wallerian degeneration protein, Wld(S).

Wilbrey AL, Haley JE, Wishart TM, Conforti L, Morreale G, Beirowski B, Babetto E, Adalbert R, Gillingwater TH, Smith T, Wyllie DJ, Ribchester RR, Coleman MP.

Mol Cell Neurosci. 2008 Jul;38(3):325-40. doi: 10.1016/j.mcn.2008.03.004. Epub 2008 Mar 25.

PMID:
18468455
3.

WldS can delay Wallerian degeneration in mice when interaction with valosin-containing protein is weakened.

Beirowski B, Morreale G, Conforti L, Mazzola F, Di Stefano M, Wilbrey A, Babetto E, Janeckova L, Magni G, Coleman MP.

Neuroscience. 2010 Mar 10;166(1):201-11. doi: 10.1016/j.neuroscience.2009.12.024. Epub 2009 Dec 16.

PMID:
20018231
4.

Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice.

Conforti L, Wilbrey A, Morreale G, Janeckova L, Beirowski B, Adalbert R, Mazzola F, Di Stefano M, Hartley R, Babetto E, Smith T, Gilley J, Billington RA, Genazzani AA, Ribchester RR, Magni G, Coleman M.

J Cell Biol. 2009 Feb 23;184(4):491-500. doi: 10.1083/jcb.200807175.

5.

Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration.

Avery MA, Sheehan AE, Kerr KS, Wang J, Freeman MR.

J Cell Biol. 2009 Feb 23;184(4):501-13. doi: 10.1083/jcb.200808042.

6.

Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo.

Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thomson D, Ribchester RR, Coleman MP.

J Neurosci. 2010 Oct 6;30(40):13291-304. doi: 10.1523/JNEUROSCI.1189-10.2010.

7.

Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.

Mack TG, Reiner M, Beirowski B, Mi W, Emanuelli M, Wagner D, Thomson D, Gillingwater T, Court F, Conforti L, Fernando FS, Tarlton A, Andressen C, Addicks K, Magni G, Ribchester RR, Perry VH, Coleman MP.

Nat Neurosci. 2001 Dec;4(12):1199-206.

PMID:
11770485
8.

Reducing expression of NAD+ synthesizing enzyme NMNAT1 does not affect the rate of Wallerian degeneration.

Conforti L, Janeckova L, Wagner D, Mazzola F, Cialabrini L, Di Stefano M, Orsomando G, Magni G, Bendotti C, Smyth N, Coleman M.

FEBS J. 2011 Aug;278(15):2666-79. doi: 10.1111/j.1742-4658.2011.08193.x. Epub 2011 Jun 14.

9.

The cellular distribution of the Wld s chimeric protein and its constituent proteins in the CNS.

Fang C, Bernardes-Silva M, Coleman MP, Perry VH.

Neuroscience. 2005;135(4):1107-18. Epub 2005 Sep 8.

PMID:
16154290
10.

A Ufd2/D4Cole1e chimeric protein and overexpression of Rbp7 in the slow Wallerian degeneration (WldS) mouse.

Conforti L, Tarlton A, Mack TG, Mi W, Buckmaster EA, Wagner D, Perry VH, Coleman MP.

Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11377-82.

11.

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.

Laço MN, Cortes L, Travis SM, Paulson HL, Rego AC.

PLoS One. 2012;7(9):e43563. doi: 10.1371/journal.pone.0043563. Epub 2012 Sep 6.

12.

The neuroprotective WldS gene regulates expression of PTTG1 and erythroid differentiation regulator 1-like gene in mice and human cells.

Gillingwater TH, Wishart TM, Chen PE, Haley JE, Robertson K, MacDonald SH, Middleton S, Wawrowski K, Shipston MJ, Melmed S, Wyllie DJ, Skehel PA, Coleman MP, Ribchester RR.

Hum Mol Genet. 2006 Feb 15;15(4):625-35. Epub 2006 Jan 10.

13.

NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration.

Conforti L, Fang G, Beirowski B, Wang MS, Sorci L, Asress S, Adalbert R, Silva A, Bridge K, Huang XP, Magni G, Glass JD, Coleman MP.

Cell Death Differ. 2007 Jan;14(1):116-27. Epub 2006 Apr 28.

14.

Evolutionary divergence of valosin-containing protein/cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins.

Morreale G, Conforti L, Coadwell J, Wilbrey AL, Coleman MP.

FEBS J. 2009 Mar;276(5):1208-20. doi: 10.1111/j.1742-4658.2008.06858.x.

15.

COP9 signalosome interacts ATP-dependently with p97/valosin-containing protein (VCP) and controls the ubiquitination status of proteins bound to p97/VCP.

Cayli S, Klug J, Chapiro J, Fröhlich S, Krasteva G, Orel L, Meinhardt A.

J Biol Chem. 2009 Dec 11;284(50):34944-53. doi: 10.1074/jbc.M109.037952. Epub 2009 Oct 13.

16.

Identification of a critical site in Wld(s): essential for Nmnat enzyme activity and axon-protective function.

Jia H, Yan T, Feng Y, Zeng C, Shi X, Zhai Q.

Neurosci Lett. 2007 Feb 8;413(1):46-51. Epub 2006 Dec 15.

PMID:
17207927
17.

A local mechanism mediates NAD-dependent protection of axon degeneration.

Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z.

J Cell Biol. 2005 Aug 1;170(3):349-55. Epub 2005 Jul 25.

18.

Wallerian degeneration, wld(s), and nmnat.

Coleman MP, Freeman MR.

Annu Rev Neurosci. 2010;33:245-67. doi: 10.1146/annurev-neuro-060909-153248. Review.

PMID:
20345246
19.

An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.

Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert BO, Müller EC, Lurz R, Breuer P, Schugardt N, Plassmann S, Xu K, Warrick JM, Suopanki J, Wüllner U, Frank R, Hartl UF, Bonini NM, Wanker EE.

EMBO J. 2006 Apr 5;25(7):1547-58. Epub 2006 Mar 9.

20.

Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration.

Yahata N, Yuasa S, Araki T.

J Neurosci. 2009 May 13;29(19):6276-84. doi: 10.1523/JNEUROSCI.4304-08.2009.

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