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Items: 1 to 20 of 182


Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4.

Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G.

Mol Cell Biol. 2006 Jan;26(1):192-8.


Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.

Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G.

Nat Genet. 2001 Sep;29(1):92-5.


Synergistic regulation of p53 by Mdm2 and Mdm4 is critical in cardiac endocardial cushion morphogenesis during heart development.

Zhang Q, He X, Chen L, Zhang C, Gao X, Yang Z, Liu G.

J Pathol. 2012 Nov;228(3):416-28. doi: 10.1002/path.4077. Epub 2012 Sep 28.


Rescue of Mdm4-deficient mice by Mdm2 reveals functional overlap of Mdm2 and Mdm4 in development.

Steinman HA, Hoover KM, Keeler ML, Sands AT, Jones SN.

Oncogene. 2005 Nov 24;24(53):7935-40.


Distinct roles of Mdm2 and Mdm4 in red cell production.

Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, Klingmuller U, Lozano G, Marine JC.

Blood. 2007 Mar 15;109(6):2630-3. Epub 2006 Nov 14.


Mdm2, but not Mdm4, protects terminally differentiated smooth muscle cells from p53-mediated caspase-3-independent cell death.

Boesten LS, Zadelaar SM, De Clercq S, Francoz S, van Nieuwkoop A, Biessen EA, Hofmann F, Feil S, Feil R, Jochemsen AG, Zurcher C, Havekes LM, van Vlijmen BJ, Marine JC.

Cell Death Differ. 2006 Dec;13(12):2089-98. Epub 2006 May 26.


Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice.

Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G.

Oncogene. 2004 Oct 7;23(46):7644-50.


Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.

Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G.

Circulation. 2007 Jun 12;115(23):2925-30. Epub 2007 May 28.


Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets.

Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G.

Cancer Res. 2003 Dec 15;63(24):8664-9.


Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development.

Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3226-31. Epub 2006 Feb 21.


A mouse p53 mutant lacking the proline-rich domain rescues Mdm4 deficiency and provides insight into the Mdm2-Mdm4-p53 regulatory network.

Toledo F, Krummel KA, Lee CJ, Liu CW, Rodewald LW, Tang M, Wahl GM.

Cancer Cell. 2006 Apr;9(4):273-85.


Mouse models of Mdm2 and Mdm4 and their clinical implications.

Xiong S.

Chin J Cancer. 2013 Jul;32(7):371-5. doi: 10.5732/cjc.012.10286. Epub 2013 Jan 18. Review.


Mdm2 and Mdm4 loss regulates distinct p53 activities.

Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G.

Mol Cancer Res. 2008 Jun;6(6):947-54. doi: 10.1158/1541-7786.MCR-07-2079.


Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4.

Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G.

Cancer Res. 2006 Oct 1;66(19):9502-8.


Widespread overexpression of epitope-tagged Mdm4 does not accelerate tumor formation in vivo.

De Clercq S, Gembarska A, Denecker G, Maetens M, Naessens M, Haigh K, Haigh JJ, Marine JC.

Mol Cell Biol. 2010 Nov;30(22):5394-405. doi: 10.1128/MCB.00330-10. Epub 2010 Sep 20.


Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity.

Giglio S, Mancini F, Pellegrino M, Di Conza G, Puxeddu E, Sacchi A, Pontecorvi A, Moretti F.

Oncogene. 2010 Nov 4;29(44):5935-45. doi: 10.1038/onc.2010.324. Epub 2010 Aug 9.


Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development.

Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G.

Mol Cell Biol. 2007 Aug;27(15):5479-85. Epub 2007 May 25.


Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo.

Francoz S, Froment P, Bogaerts S, De Clercq S, Maetens M, Doumont G, Bellefroid E, Marine JC.

Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3232-7. Epub 2006 Feb 21.


MDM4 (MDMX) overexpression enhances stabilization of stress-induced p53 and promotes apoptosis.

Mancini F, Gentiletti F, D'Angelo M, Giglio S, Nanni S, D'Angelo C, Farsetti A, Citro G, Sacchi A, Pontecorvi A, Moretti F.

J Biol Chem. 2004 Feb 27;279(9):8169-80. Epub 2003 Dec 1.


Absence of p21 partially rescues Mdm4 loss and uncovers an antiproliferative effect of Mdm4 on cell growth.

Steinman HA, Sluss HK, Sands AT, Pihan G, Jones SN.

Oncogene. 2004 Jan 8;23(1):303-6.

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