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Items: 1 to 20 of 164

1.

A role for LEDGF/p75 in targeting HIV DNA integration.

Ciuffi A, Llano M, Poeschla E, Hoffmann C, Leipzig J, Shinn P, Ecker JR, Bushman F.

Nat Med. 2005 Dec;11(12):1287-9. Epub 2005 Nov 27.

PMID:
16311605
2.

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.

Vandekerckhove L, Christ F, Van Maele B, De Rijck J, Gijsbers R, Van den Haute C, Witvrouw M, Debyser Z.

J Virol. 2006 Feb;80(4):1886-96.

3.

An essential role for LEDGF/p75 in HIV integration.

Llano M, Saenz DT, Meehan A, Wongthida P, Peretz M, Walker WH, Teo W, Poeschla EM.

Science. 2006 Oct 20;314(5798):461-4. Epub 2006 Sep 7.

4.

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

Hombrouck A, De Rijck J, Hendrix J, Vandekerckhove L, Voet A, De Maeyer M, Witvrouw M, Engelborghs Y, Christ F, Gijsbers R, Debyser Z.

PLoS Pathog. 2007 Mar;3(3):e47.

5.
6.

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

Du L, Zhao Y, Chen J, Yang L, Zheng Y, Tang Y, Shen X, Jiang H.

Biochem Biophys Res Commun. 2008 Oct 10;375(1):139-44. doi: 10.1016/j.bbrc.2008.07.139. Epub 2008 Aug 6.

PMID:
18691555
7.

Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase.

Llano M, Delgado S, Vanegas M, Poeschla EM.

J Biol Chem. 2004 Dec 31;279(53):55570-7. Epub 2004 Oct 8.

9.

Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells.

Levin A, Hayouka Z, Friedler A, Loyter A.

Virol J. 2010 Aug 2;7:177. doi: 10.1186/1743-422X-7-177.

10.

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.

Marshall HM, Ronen K, Berry C, Llano M, Sutherland H, Saenz D, Bickmore W, Poeschla E, Bushman FD.

PLoS One. 2007 Dec 19;2(12):e1340.

11.

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.

Vanegas M, Llano M, Delgado S, Thompson D, Peretz M, Poeschla E.

J Cell Sci. 2005 Apr 15;118(Pt 8):1733-43. Epub 2005 Mar 29.

12.

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs.

Schrijvers R, De Rijck J, Demeulemeester J, Adachi N, Vets S, Ronen K, Christ F, Bushman FD, Debyser Z, Gijsbers R.

PLoS Pathog. 2012;8(3):e1002558. doi: 10.1371/journal.ppat.1002558. Epub 2012 Mar 1.

13.

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication.

Emiliani S, Mousnier A, Busschots K, Maroun M, Van Maele B, Tempé D, Vandekerckhove L, Moisant F, Ben-Slama L, Witvrouw M, Christ F, Rain JC, Dargemont C, Debyser Z, Benarous R.

J Biol Chem. 2005 Jul 8;280(27):25517-23. Epub 2005 Apr 25.

14.

Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication.

Christ F, Voet A, Marchand A, Nicolet S, Desimmie BA, Marchand D, Bardiot D, Van der Veken NJ, Van Remoortel B, Strelkov SV, De Maeyer M, Chaltin P, Debyser Z.

Nat Chem Biol. 2010 Jun;6(6):442-8. doi: 10.1038/nchembio.370. Epub 2010 May 16.

PMID:
20473303
15.

Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting.

Gijsbers R, Vets S, De Rijck J, Ocwieja KE, Ronen K, Malani N, Bushman FD, Debyser Z.

J Biol Chem. 2011 Dec 2;286(48):41812-25. doi: 10.1074/jbc.M111.255711. Epub 2011 Oct 10.

16.

Retroviral DNA integration: HIV and the role of LEDGF/p75.

Ciuffi A, Bushman FD.

Trends Genet. 2006 Jul;22(7):388-95. Epub 2006 May 26. Review.

PMID:
16730094
17.

Cellular co-factors of HIV-1 integration.

Van Maele B, Busschots K, Vandekerckhove L, Christ F, Debyser Z.

Trends Biochem Sci. 2006 Feb;31(2):98-105. Epub 2006 Jan 5. Review.

PMID:
16403635
18.
19.

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells.

Maertens G, Cherepanov P, Pluymers W, Busschots K, De Clercq E, Debyser Z, Engelborghs Y.

J Biol Chem. 2003 Aug 29;278(35):33528-39. Epub 2003 Jun 9.

20.

Integration of HIV-1 DNA is regulated by interplay between viral rev and cellular LEDGF/p75 proteins.

Levin A, Rosenbluh J, Hayouka Z, Friedler A, Loyter A.

Mol Med. 2010 Jan-Feb;16(1-2):34-44. doi: 10.2119/molmed.2009.00133. Epub 2009 Oct 29.

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