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gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.

Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J.

Mol Cell. 2005 Dec 9;20(5):801-9. Epub 2005 Nov 28.


Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair.

Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA.

J Biol Chem. 2010 Apr 23;285(17):12935-47. doi: 10.1074/jbc.M109.071696. Epub 2010 Jan 29.


Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

Douglas P, Zhong J, Ye R, Moorhead GB, Xu X, Lees-Miller SP.

Mol Cell Biol. 2010 Mar;30(6):1368-81. doi: 10.1128/MCB.00741-09. Epub 2010 Jan 11.


A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication.

Chowdhury D, Xu X, Zhong X, Ahmed F, Zhong J, Liao J, Dykxhoorn DM, Weinstock DM, Pfeifer GP, Lieberman J.

Mol Cell. 2008 Jul 11;31(1):33-46. doi: 10.1016/j.molcel.2008.05.016.


Dephosphorylation of γ-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control.

Moon SH, Nguyen TA, Darlington Y, Lu X, Donehower LA.

Cell Cycle. 2010 Jun 1;9(11):2092-6. Epub 2010 Jun 1.


Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.

Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH.

Oncogene. 2010 Apr 15;29(15):2281-91. doi: 10.1038/onc.2009.501. Epub 2010 Jan 25.


UV-induced histone H2AX phosphorylation and DNA damage related proteins accumulate and persist in nucleotide excision repair-deficient XP-B cells.

Oh KS, Bustin M, Mazur SJ, Appella E, Kraemer KH.

DNA Repair (Amst). 2011 Jan 2;10(1):5-15. doi: 10.1016/j.dnarep.2010.09.004. Epub 2010 Oct 13.


DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression.

An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC, Zhou PK.

BMC Mol Biol. 2010 Mar 6;11:18. doi: 10.1186/1471-2199-11-18.


Ataxia telangiectasia mutated (ATM) is dispensable for endonuclease I-SceI-induced homologous recombination in mouse embryonic stem cells.

Rass E, Chandramouly G, Zha S, Alt FW, Xie A.

J Biol Chem. 2013 Mar 8;288(10):7086-95. doi: 10.1074/jbc.M112.445825. Epub 2013 Jan 26.


Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, Moorhead GB, Lees-Miller SP, Khanna KK.

EMBO J. 2004 Nov 10;23(22):4451-61. Epub 2004 Oct 28.


Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1.

Kobayashi J, Tauchi H, Chen B, Burma S, Tashiro S, Matsuura S, Tanimoto K, Chen DJ, Komatsu K.

Biochem Biophys Res Commun. 2009 Mar 20;380(4):752-7. doi: 10.1016/j.bbrc.2009.01.109. Epub 2009 Jan 23. Erratum in: Biochem Biophys Res Commun. 2009 Jun 26;384(2):271. Bruma, Sandeep [corrected to Burma, Sandeep].


Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK.

Meyer B, Voss KO, Tobias F, Jakob B, Durante M, Taucher-Scholz G.

Nucleic Acids Res. 2013 Jul;41(12):6109-18. doi: 10.1093/nar/gkt304. Epub 2013 Apr 24.


Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

Nazarov IB, Smirnova AN, Krutilina RI, Svetlova MP, Solovjeva LV, Nikiforov AA, Oei SL, Zalenskaya IA, Yau PM, Bradbury EM, Tomilin NV.

Radiat Res. 2003 Sep;160(3):309-17.


Protein phosphatase 2A antagonizes ATM and ATR in a Cdk2- and Cdc7-independent DNA damage checkpoint.

Petersen P, Chou DM, You Z, Hunter T, Walter JC, Walter G.

Mol Cell Biol. 2006 Mar;26(5):1997-2011.


Evidence for the direct binding of phosphorylated p53 to sites of DNA breaks in vivo.

Al Rashid ST, Dellaire G, Cuddihy A, Jalali F, Vaid M, Coackley C, Folkard M, Xu Y, Chen BP, Chen DJ, Lilge L, Prise KM, Bazett Jones DP, Bristow RG.

Cancer Res. 2005 Dec 1;65(23):10810-21.


ATM-mediated phosphorylation of the chromatin remodeling enzyme BRG1 modulates DNA double-strand break repair.

Kwon SJ, Park JH, Park EJ, Lee SA, Lee HS, Kang SW, Kwon J.

Oncogene. 2015 Jan 15;34(3):303-13. doi: 10.1038/onc.2013.556. Epub 2014 Jan 13.


Targeting protein for xenopus kinesin-like protein 2 (TPX2) regulates γ-histone 2AX (γ-H2AX) levels upon ionizing radiation.

Neumayer G, Helfricht A, Shim SY, Le HT, Lundin C, Belzil C, Chansard M, Yu Y, Lees-Miller SP, Gruss OJ, van Attikum H, Helleday T, Nguyen MD.

J Biol Chem. 2012 Dec 7;287(50):42206-22. doi: 10.1074/jbc.M112.385674. Epub 2012 Oct 8.


Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting gamma-H2AX induction.

Park JH, Park EJ, Lee HS, Kim SJ, Hur SK, Imbalzano AN, Kwon J.

EMBO J. 2006 Sep 6;25(17):3986-97. Epub 2006 Aug 24.


ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.

Tanaka T, Huang X, Jorgensen E, Gietl D, Traganos F, Darzynkiewicz Z, Albino AP.

BMC Cell Biol. 2007 Jun 26;8:26.


PP2A-B56ϵ complex is involved in dephosphorylation of γ-H2AX in the repair process of CPT-induced DNA double-strand breaks.

Li X, Nan A, Xiao Y, Chen Y, Lai Y.

Toxicology. 2015 May 4;331:57-65. doi: 10.1016/j.tox.2015.03.007. Epub 2015 Mar 12.

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