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Items: 1 to 20 of 213

1.

Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.

López-Lázaro M, Pastor N, Azrak SS, Ayuso MJ, Austin CA, Cortés F.

J Nat Prod. 2005 Nov;68(11):1642-5.

PMID:
16309315
2.

Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells.

Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Claeson P.

Anticancer Drugs. 2001 Jun;12(5):475-83.

PMID:
11395576
3.

Digitoxin, at concentrations commonly found in the plasma of cardiac patients, antagonizes etoposide and idarubicin activity in K562 leukemia cells.

López-Lázaro M, Pastor N, Azrak SS, Ayuso MJ, Cortés F, Austin CA.

Leuk Res. 2006 Jul;30(7):895-8. Epub 2006 Jan 4.

PMID:
16387358
4.

Curcumin as a DNA topoisomerase II poison.

Martín-Cordero C, López-Lázaro M, Gálvez M, Ayuso MJ.

J Enzyme Inhib Med Chem. 2003 Dec;18(6):505-9.

PMID:
15008515
5.

Cardiac glycosides in cancer research and cancer therapy.

Winnicka K, Bielawski K, Bielawska A.

Acta Pol Pharm. 2006 Mar-Apr;63(2):109-15. Review.

6.
7.

Cardiac glycosides decrease prostate specific antigen expression by down-regulation of prostate derived Ets factor.

Juang HH, Lin YF, Chang PL, Tsui KH.

J Urol. 2010 Nov;184(5):2158-64. doi: 10.1016/j.juro.2010.06.093. Epub 2010 Sep 17.

PMID:
20850842
8.

Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved.

López-Lázaro M.

Expert Opin Ther Targets. 2007 Aug;11(8):1043-53. Review.

PMID:
17665977
9.

The dynamics of cell proliferation.

Moxnes JF, Haux J, Hausken K.

Med Hypotheses. 2004;62(4):556-63.

PMID:
15050107
10.

DA-125, a new antitumor agent, inhibits topoisomerase II as topoisomerase poison and DNA intercalator simultaneously.

Seo J, Lee HS, Lee M, Kim M, Shin CG.

Arch Pharm Res. 2004 Jan;27(1):77-82.

PMID:
14969343
11.

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity.

Swift LP, Cutts SM, Nudelman A, Levovich I, Rephaeli A, Phillips DR.

Cancer Chemother Pharmacol. 2008 Apr;61(5):739-49. Epub 2007 Jun 27.

PMID:
17594094
12.

The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual properties.

Lemke K, Poindessous V, Skladanowski A, Larsen AK.

Mol Pharmacol. 2004 Oct;66(4):1035-42. Epub 2004 Jul 16.

13.

Structure-activity studies with cytotoxic anthrapyrazoles.

Begleiter A, Lin D, Larson KK, Lang J, Wu X, Cabral T, Taylor H, Guziec LJ, Kerr PD, Hasinoff BB, Guziec FS Jr.

Oncol Rep. 2006 Jun;15(6):1575-80.

PMID:
16685398
14.

Roles of nonhomologous end-joining pathways in surviving topoisomerase II-mediated DNA damage.

Malik M, Nitiss KC, Enriquez-Rios V, Nitiss JL.

Mol Cancer Ther. 2006 Jun;5(6):1405-14.

15.

Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models.

Hoch U, Lynch J, Sato Y, Kashimoto S, Kajikawa F, Furutani Y, Silverman JA.

Cancer Chemother Pharmacol. 2009 Jun;64(1):53-65. doi: 10.1007/s00280-008-0850-3. Epub 2008 Oct 19.

PMID:
18931998
16.
17.

Proliferation and apoptosis of HeLa cells induced by in vitro stimulation with digitalis.

Ramirez-Ortega M, Maldonado-Lagunas V, Melendez-Zajgla J, Carrillo-Hernandez JF, Pastelín-Hernandez G, Picazo-Picazo O, Ceballos-Reyes G.

Eur J Pharmacol. 2006 Mar 18;534(1-3):71-6. Epub 2006 Feb 28.

PMID:
16507306
18.

A three-dimensional quantitative structure-activity analysis of a new class of bisphenol topoisomerase IIalpha inhibitors.

Liang H, Wu X, Yalowich JC, Hasinoff BB.

Mol Pharmacol. 2008 Mar;73(3):686-96. Epub 2007 Nov 28.

19.

Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.

Vispé S, Vandenberghe I, Robin M, Annereau JP, Créancier L, Pique V, Galy JP, Kruczynski A, Barret JM, Bailly C.

Biochem Pharmacol. 2007 Jun 15;73(12):1863-72. Epub 2007 Mar 3.

PMID:
17391647
20.

Role of topoisomerases in cytotoxicity induced by DNA ligand Hoechst-33342 and UV-C in a glioma cell line.

Singh S, Dwarakanath BS, Lazar Mathew T.

Indian J Exp Biol. 2005 Apr;43(4):313-23.

PMID:
15875714
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