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btn1, the Schizosaccharomyces pombe homologue of the human Batten disease gene CLN3, regulates vacuole homeostasis.

Gachet Y, Codlin S, Hyams JS, Mole SE.

J Cell Sci. 2005 Dec 1;118(Pt 23):5525-36. Epub 2005 Nov 15.


S. pombe btn1, the orthologue of the Batten disease gene CLN3, is required for vacuole protein sorting of Cpy1p and Golgi exit of Vps10p.

Codlin S, Mole SE.

J Cell Sci. 2009 Apr 15;122(Pt 8):1163-73. doi: 10.1242/jcs.038323. Epub 2009 Mar 19.


Action of BTN1, the yeast orthologue of the gene mutated in Batten disease.

Pearce DA, Ferea T, Nosel SA, Das B, Sherman F.

Nat Genet. 1999 May;22(1):55-8.


Btn1 affects cytokinesis and cell-wall deposition by independent mechanisms, one of which is linked to dysregulation of vacuole pH.

Codlin S, Haines RL, Burden JJ, Mole SE.

J Cell Sci. 2008 Sep 1;121(Pt 17):2860-70. doi: 10.1242/jcs.030122. Epub 2008 Aug 12.


The yeast model for batten disease: mutations in BTN1, BTN2, and HSP30 alter pH homeostasis.

Chattopadhyay S, Muzaffar NE, Sherman F, Pearce DA.

J Bacteriol. 2000 Nov;182(22):6418-23.


The fission yeast model for the lysosomal storage disorder Batten disease predicts disease severity caused by mutations in CLN3.

Haines RL, Codlin S, Mole SE.

Dis Model Mech. 2009 Jan-Feb;2(1-2):84-92. doi: 10.1242/dmm.000851. Epub 2008 Dec 22.


Absence of Btn1p in the yeast model for juvenile Batten disease may cause arginine to become toxic to yeast cells.

Vitiello SP, Wolfe DM, Pearce DA.

Hum Mol Genet. 2007 May 1;16(9):1007-16. Epub 2007 Mar 6.


Saccharomyces cerevisiae lacking Btn1p modulate vacuolar ATPase activity to regulate pH imbalance in the vacuole.

Padilla-López S, Pearce DA.

J Biol Chem. 2006 Apr 14;281(15):10273-80. Epub 2006 Jan 18.


A role in vacuolar arginine transport for yeast Btn1p and for human CLN3, the protein defective in Batten disease.

Kim Y, Ramirez-Montealegre D, Pearce DA.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15458-62. Epub 2003 Dec 5.


The subcellular location of the yeast Saccharomyces cerevisiae homologue of the protein defective in the juvenile form of Batten disease.

Croopnick JB, Choi HC, Mueller DM.

Biochem Biophys Res Commun. 1998 Sep 18;250(2):335-41.


Investigation of Batten disease with the yeast Saccharomyces cerevisiae.

Pearce DA, Sherman F.

Mol Genet Metab. 1999 Apr;66(4):314-9.


BTN1, the Saccharomyces cerevisiae homolog to the human Batten disease gene, is involved in phospholipid distribution.

Padilla-López S, Langager D, Chan CH, Pearce DA.

Dis Model Mech. 2012 Mar;5(2):191-9. doi: 10.1242/dmm.008490. Epub 2011 Nov 22.


Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.

Pears MR, Codlin S, Haines RL, White IJ, Mortishire-Smith RJ, Mole SE, Griffin JL.

Mol Biosyst. 2010 Jun;6(6):1093-102. doi: 10.1039/b915670d. Epub 2010 Mar 17.


A yeast model for the study of Batten disease.

Pearce DA, Sherman F.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6915-8.


Phenotypic reversal of the btn1 defects in yeast by chloroquine: a yeast model for Batten disease.

Pearce DA, Carr CJ, Das B, Sherman F.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11341-5.


Studies of pH regulation by Btn1p, the yeast homolog of human Cln3p.

Pearce DA, Nosel SA, Sherman F.

Mol Genet Metab. 1999 Apr;66(4):320-3.


btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe.

Codlin S, Haines RL, Mole SE.

Traffic. 2008 Jun;9(6):936-50. doi: 10.1111/j.1600-0854.2008.00735.x. Epub 2008 Mar 10.


Interaction between Sdo1p and Btn1p in the Saccharomyces cerevisiae model for Batten disease.

Vitiello SP, Benedict JW, Padilla-Lopez S, Pearce DA.

Hum Mol Genet. 2010 Mar 1;19(5):931-42. doi: 10.1093/hmg/ddp560. Epub 2009 Dec 16.


Defective lysosomal arginine transport in juvenile Batten disease.

Ramirez-Montealegre D, Pearce DA.

Hum Mol Genet. 2005 Dec 1;14(23):3759-73. Epub 2005 Oct 26.


Vacuolar protein sorting receptor in Schizosaccharomyces pombe.

Iwaki T, Hosomi A, Tokudomi S, Kusunoki Y, Fujita Y, Giga-Hama Y, Tanaka N, Takegawa K.

Microbiology. 2006 May;152(Pt 5):1523-32.

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