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Results: 1 to 20 of 209

1.

In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors.

Zhang YJ, Wang Z, Sprous D, Nabioullin R.

Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8.

PMID:
16288866
[PubMed - indexed for MEDLINE]
2.

PRO_SELECT: combining structure-based drug design and array-based chemistry for rapid lead discovery. 2. The development of a series of highly potent and selective factor Xa inhibitors.

Liebeschuetz JW, Jones SD, Morgan PJ, Murray CW, Rimmer AD, Roscoe JM, Waszkowycz B, Welsh PM, Wylie WA, Young SC, Martin H, Mahler J, Brady L, Wilkinson K.

J Med Chem. 2002 Mar 14;45(6):1221-32.

PMID:
11881991
[PubMed - indexed for MEDLINE]
3.

Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode.

Finlay MR, Acton DG, Andrews DM, Barker AJ, Dennis M, Fisher E, Graham MA, Green CP, Heaton DW, Karoutchi G, Loddick SA, Morgentin R, Roberts A, Tucker JA, Weir HM.

Bioorg Med Chem Lett. 2008 Aug 1;18(15):4442-6. doi: 10.1016/j.bmcl.2008.06.027. Epub 2008 Jun 12.

PMID:
18617397
[PubMed - indexed for MEDLINE]
4.

Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors.

Naerum L, Nørskov-Lauritsen L, Olesen PH.

Bioorg Med Chem Lett. 2002 Jun 3;12(11):1525-8.

PMID:
12031334
[PubMed - indexed for MEDLINE]
5.

Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.

Li J, Zhang J, Chen J, Luo X, Zhu W, Shen J, Liu H, Shen X, Jiang H.

J Comb Chem. 2006 May-Jun;8(3):326-37.

PMID:
16677001
[PubMed - indexed for MEDLINE]
6.

Design, synthesis and preliminary evaluation of new cinnamoyl pyrrolidine derivatives as potent gelatinase inhibitors.

Zhang L, Zhang J, Fang H, Wang Q, Xu W.

Bioorg Med Chem. 2006 Dec 15;14(24):8286-94. Epub 2006 Sep 27.

PMID:
17008101
[PubMed - indexed for MEDLINE]
7.

In silico-guided target identification of a scaffold-focused library: 1,3,5-triazepan-2,6-diones as novel phospholipase A2 inhibitors.

Muller P, Lena G, Boilard E, Bezzine S, Lambeau G, Guichard G, Rognan D.

J Med Chem. 2006 Nov 16;49(23):6768-78.

PMID:
17154507
[PubMed - indexed for MEDLINE]
8.

Discovery of novel leukotriene A4 hydrolase inhibitors based on piperidine and piperazine scaffolds.

Sandanayaka V, Mamat B, Bhagat N, Bedell L, Halldorsdottir G, Sigthorsdottir H, Andrésson T, Kiselyov A, Gurney M, Singh J.

Bioorg Med Chem Lett. 2010 May 1;20(9):2851-4. doi: 10.1016/j.bmcl.2010.03.047. Epub 2010 Mar 12.

PMID:
20371179
[PubMed - indexed for MEDLINE]
9.

Molecular scaffold-based design and comparison of combinatorial libraries focused on the ATP-binding site of protein kinases.

Stahura FL, Xue L, Godden JW, Bajorath J.

J Mol Graph Model. 1999 Feb;17(1):1-9, 51-2.

PMID:
10660905
[PubMed - indexed for MEDLINE]
10.

In silico fragment screening by replica generation (FSRG) method for fragment-based drug design.

Fukunishi Y, Mashimo T, Orita M, Ohno K, Nakamura H.

J Chem Inf Model. 2009 Apr;49(4):925-33. doi: 10.1021/ci800435x.

PMID:
19354203
[PubMed - indexed for MEDLINE]
11.

Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors.

Cheng XC, Wang Q, Fang H, Tang W, Xu WF.

Eur J Med Chem. 2008 Oct;43(10):2130-9. doi: 10.1016/j.ejmech.2007.12.020. Epub 2007 Dec 31.

PMID:
18362041
[PubMed - indexed for MEDLINE]
12.

Crystallographic study of inhibitors of tRNA-guanine transglycosylase suggests a new structure-based pharmacophore for virtual screening.

Brenk R, Meyer EA, Reuter K, Stubbs MT, Garcia GA, Diederich F, Klebe G.

J Mol Biol. 2004 Apr 16;338(1):55-75.

PMID:
15050823
[PubMed - indexed for MEDLINE]
13.

Design, synthesis, and biological activities of pyrrolylethanoneamine derivatives, a novel class of monoamine oxidases inhibitors.

Di Santo R, Costi R, Roux A, Artico M, Befani O, Meninno T, Agostinelli E, Palmegiani P, Turini P, Cirilli R, Ferretti R, Gallinella B, La Torre F.

J Med Chem. 2005 Jun 30;48(13):4220-3.

PMID:
15974574
[PubMed - indexed for MEDLINE]
14.

Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Stoll V, Stewart KD, Maring CJ, Muchmore S, Giranda V, Gu YG, Wang G, Chen Y, Sun M, Zhao C, Kennedy AL, Madigan DL, Xu Y, Saldivar A, Kati W, Laver G, Sowin T, Sham HL, Greer J, Kempf D.

Biochemistry. 2003 Jan 28;42(3):718-27.

PMID:
12534284
[PubMed - indexed for MEDLINE]
15.

Discovery and initial SAR of arylsulfonylpiperazine inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

Sun D, Wang Z, Di Y, Jaen JC, Labelle M, Ma J, Miao S, Sudom A, Tang L, Tomooka CS, Tu H, Ursu S, Walker N, Yan X, Ye Q, Powers JP.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3513-6. doi: 10.1016/j.bmcl.2008.05.025. Epub 2008 May 10.

PMID:
18511278
[PubMed - indexed for MEDLINE]
16.

Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors.

Luksch T, Chan NS, Brass S, Sotriffer CA, Klebe G, Diederich WE.

ChemMedChem. 2008 Sep;3(9):1323-36. doi: 10.1002/cmdc.200700270.

PMID:
18752222
[PubMed - indexed for MEDLINE]
17.

Design and synthesis of phosphotyrosine mimetics.

Yan Z, Kahn M, Qabar M, Urban J, Kim HO, Blaskovich MA.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2083-5.

PMID:
12781200
[PubMed - indexed for MEDLINE]
18.

Synthesis and optimization of a new family of type 3 17 beta-hydroxysteroid dehydrogenase inhibitors by parallel liquid-phase chemistry.

Maltais R, Luu-The V, Poirier D.

J Med Chem. 2002 Jan 31;45(3):640-53.

PMID:
11806715
[PubMed - indexed for MEDLINE]
19.

Design and synthesis of disubstituted (4-piperidinyl)-piperazine derivatives as potent acetyl-CoA carboxylase inhibitors.

Chonan T, Tanaka H, Yamamoto D, Yashiro M, Oi T, Wakasugi D, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3965-8. doi: 10.1016/j.bmcl.2010.04.134. Epub 2010 May 4.

PMID:
20537533
[PubMed - indexed for MEDLINE]
20.

Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors.

Powell NA, Clay EH, Holsworth DD, Bryant JW, Ryan MJ, Jalaie M, Zhang E, Edmunds JJ.

Bioorg Med Chem Lett. 2005 May 2;15(9):2371-4.

PMID:
15837327
[PubMed - indexed for MEDLINE]
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