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Items: 1 to 20 of 116

1.

Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.

Li Y, Chen J, Lu W, McCormick LM, Wang J, Bu G.

J Cell Sci. 2005 Nov 15;118(Pt 22):5305-14. Epub 2005 Nov 1.

2.

Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.

Lu W, Liu CC, Thottassery JV, Bu G, Li Y.

Biochemistry. 2010 Jun 8;49(22):4635-43. doi: 10.1021/bi1001486.

3.

The C-terminal region Mesd peptide mimics full-length Mesd and acts as an inhibitor of Wnt/β-catenin signaling in cancer cells.

Lin C, Lu W, Zhang W, Londoño-Joshi AI, Buchsbaum DJ, Bu G, Li Y.

PLoS One. 2013;8(2):e58102. doi: 10.1371/journal.pone.0058102. Epub 2013 Feb 28.

4.

Modulation of LRP6-mediated Wnt signaling by molecular chaperone Mesd.

Li Y, Lu W, He X, Bu G.

FEBS Lett. 2006 Oct 2;580(22):5423-8. Epub 2006 Sep 18.

5.

Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.

Liu CC, Pearson C, Bu G.

J Biol Chem. 2009 May 29;284(22):15299-307. doi: 10.1074/jbc.M807285200. Epub 2009 Mar 31.

6.

A cell-based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild-type and the high bone mass mutant LRP5(G171V).

Murrills RJ, Matteo JJ, Bhat BM, Coleburn VE, Allen KM, Chen W, Damagnez V, Bhat RA, Bex FJ, Bodine PV.

J Cell Biochem. 2009 Dec 1;108(5):1066-75. doi: 10.1002/jcb.22335.

PMID:
19746449
7.

Lrp6 hypomorphic mutation affects bone mass through bone resorption in mice and impairs interaction with Mesd.

Kubota T, Michigami T, Sakaguchi N, Kokubu C, Suzuki A, Namba N, Sakai N, Nakajima S, Imai K, Ozono K.

J Bone Miner Res. 2008 Oct;23(10):1661-71. doi: 10.1359/jbmr.080512.

8.

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.

J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21.

9.

R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling.

Wei Q, Yokota C, Semenov MV, Doble B, Woodgett J, He X.

J Biol Chem. 2007 May 25;282(21):15903-11. Epub 2007 Mar 30.

10.

Mesd is a general inhibitor of different Wnt ligands in Wnt/LRP signaling and inhibits PC-3 tumor growth in vivo.

Lin C, Lu W, Zhai L, Bethea T, Berry K, Qu Z, Waud WR, Li Y.

FEBS Lett. 2011 Oct 3;585(19):3120-5. doi: 10.1016/j.febslet.2011.08.046. Epub 2011 Sep 5.

12.
13.

Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.

Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC.

Cell. 2003 Feb 7;112(3):355-67.

14.

Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.

Chen J, Liu CC, Li Q, Nowak C, Bu G, Wang J.

Structure. 2011 Mar 9;19(3):313-23. doi: 10.1016/j.str.2011.01.010.

15.

Dkk1 stabilizes Wnt co-receptor LRP6: implication for Wnt ligand-induced LRP6 down-regulation.

Li Y, Lu W, King TD, Liu CC, Bijur GN, Bu G.

PLoS One. 2010 Jun 8;5(6):e11014. doi: 10.1371/journal.pone.0011014.

16.

DKK1 antagonizes Wnt signaling without promotion of LRP6 internalization and degradation.

Semënov MV, Zhang X, He X.

J Biol Chem. 2008 Aug 1;283(31):21427-32. doi: 10.1074/jbc.M800014200. Epub 2008 May 27.

17.

Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling.

Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, Harris SE, Wu D.

J Biol Chem. 2005 May 20;280(20):19883-7. Epub 2005 Mar 18.

18.

LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.

He X, Semenov M, Tamai K, Zeng X.

Development. 2004 Apr;131(8):1663-77. Review.

19.

The structure of MESD45-184 brings light into the mechanism of LDLR family folding.

Köhler C, Lighthouse JK, Werther T, Andersen OM, Diehl A, Schmieder P, Du J, Holdener BC, Oschkinat H.

Structure. 2011 Mar 9;19(3):337-48. doi: 10.1016/j.str.2010.12.022.

20.

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.

Ettenberg SA, Charlat O, Daley MP, Liu S, Vincent KJ, Stuart DD, Schuller AG, Yuan J, Ospina B, Green J, Yu Q, Walsh R, Li S, Schmitz R, Heine H, Bilic S, Ostrom L, Mosher R, Hartlepp KF, Zhu Z, Fawell S, Yao YM, Stover D, Finan PM, Porter JA, Sellers WR, Klagge IM, Cong F.

Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15473-8. doi: 10.1073/pnas.1007428107. Epub 2010 Aug 16.

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