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Similar articles for PubMed (Select 16236797)


Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain.

Evans JH, Murray D, Leslie CC, Falke JJ.

Mol Biol Cell. 2006 Jan;17(1):56-66. Epub 2005 Oct 19.


Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity.

Corbin JA, Evans JH, Landgraf KE, Falke JJ.

Biochemistry. 2007 Apr 10;46(14):4322-36. Epub 2007 Mar 17.


The calcium binding loops of the cytosolic phospholipase A2 C2 domain specify targeting to Golgi and ER in live cells.

Evans JH, Gerber SH, Murray D, Leslie CC.

Mol Biol Cell. 2004 Jan;15(1):371-83. Epub 2003 Sep 17.


Effect of PIP2 binding on the membrane docking geometry of PKC alpha C2 domain: an EPR site-directed spin-labeling and relaxation study.

Landgraf KE, Malmberg NJ, Falke JJ.

Biochemistry. 2008 Aug 12;47(32):8301-16. doi: 10.1021/bi800711t. Epub 2008 Jul 9.


The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.

Sánchez-Bautista S, Marín-Vicente C, Gómez-Fernández JC, Corbalán-García S.

J Mol Biol. 2006 Oct 6;362(5):901-14. Epub 2006 Aug 9.


Structural and mechanistic insights into the association of PKCalpha-C2 domain to PtdIns(4,5)P2.

Guerrero-Valero M, Ferrer-Orta C, Querol-Audí J, Marin-Vicente C, Fita I, Gómez-Fernández JC, Verdaguer N, Corbalán-García S.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6603-7. doi: 10.1073/pnas.0813099106. Epub 2009 Apr 3.


The origin of C1A-C2 interdomain interactions in protein kinase Calpha.

Stahelin RV, Wang J, Blatner NR, Rafter JD, Murray D, Cho W.

J Biol Chem. 2005 Oct 28;280(43):36452-63. Epub 2005 Aug 3.


The C2 domains of classical PKCs are specific PtdIns(4,5)P2-sensing domains with different affinities for membrane binding.

Guerrero-Valero M, Marín-Vicente C, Gómez-Fernández JC, Corbalán-García S.

J Mol Biol. 2007 Aug 17;371(3):608-21. Epub 2007 Jun 2.


Electrostatic and hydrophobic interactions differentially tune membrane binding kinetics of the C2 domain of protein kinase Cα.

Scott AM, Antal CE, Newton AC.

J Biol Chem. 2013 Jun 7;288(23):16905-15. doi: 10.1074/jbc.M113.467456. Epub 2013 Apr 15.


Membrane docking geometry and target lipid stoichiometry of membrane-bound PKCα C2 domain: a combined molecular dynamics and experimental study.

Lai CL, Landgraf KE, Voth GA, Falke JJ.

J Mol Biol. 2010 Sep 17;402(2):301-10. doi: 10.1016/j.jmb.2010.07.037. Epub 2010 Jul 24.


Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity.

Egea-Jiménez AL, Pérez-Lara A, Corbalán-García S, Gómez-Fernández JC.

PLoS One. 2013 Jul 10;8(7):e69041. doi: 10.1371/journal.pone.0069041. Print 2013.


The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells.

Marín-Vicente C, Nicolás FE, Gómez-Fernández JC, Corbalán-García S.

J Mol Biol. 2008 Apr 4;377(4):1038-52. doi: 10.1016/j.jmb.2007.12.011. Epub 2007 Dec 8.


Protein kinase calpha targeting is regulated by temporal and spatial changes in intracellular free calcium concentration [Ca(2+)](i).

Maasch C, Wagner S, Lindschau C, Alexander G, Buchner K, Gollasch M, Luft FC, Haller H.

FASEB J. 2000 Aug;14(11):1653-63.


Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha.

Ochoa WF, Corbalán-Garcia S, Eritja R, Rodríguez-Alfaro JA, Gómez-Fernández JC, Fita I, Verdaguer N.

J Mol Biol. 2002 Jul 5;320(2):277-91.


Protein kinase Calpha can undergo membrane localization via an alternative phosphatidylinositol 4,5-bisphosphate-dependent pathway.

Son H, Lim Y, Kim J, Park H, Choi S, Han I, Kim WS, Park S, Bae Y, Oh ES.

Arch Biochem Biophys. 2006 Oct 1;454(1):1-6. Epub 2006 Aug 23.


The cytosolic phospholipase A2 catalytic domain modulates association and residence time at Golgi membranes.

Evans JH, Leslie CC.

J Biol Chem. 2004 Feb 13;279(7):6005-16. Epub 2003 Nov 17.

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