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Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.

Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14010-5. Epub 2005 Sep 19.


Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.

Zhu F, Wang P, Lee NH, Goldring MB, Konstantopoulos K.

PLoS One. 2010 Dec 29;5(12):e15174. doi: 10.1371/journal.pone.0015174.


Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation.

Wang P, Zhu F, Lee NH, Konstantopoulos K.

J Biol Chem. 2010 Aug 6;285(32):24793-804. doi: 10.1074/jbc.M110.110320. Epub 2010 Jun 1.


Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.

Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K.

Cell Death Differ. 2010 Aug;17(8):1325-34. doi: 10.1038/cdd.2010.13. Epub 2010 Feb 12.


Role of p53 in human chondrocyte apoptosis in response to shear strain.

Hashimoto S, Nishiyama T, Hayashi S, Fujishiro T, Takebe K, Kanzaki N, Kuroda R, Kurosaka M.

Arthritis Rheum. 2009 Aug;60(8):2340-9. doi: 10.1002/art.24706.


Regulation of plasminogen activator inhibitor 1 expression in human osteoarthritic chondrocytes by fluid shear stress: role of protein kinase Calpha.

Yeh CC, Chang HI, Chiang JK, Tsai WT, Chen LM, Wu CP, Chien S, Chen CN.

Arthritis Rheum. 2009 Aug;60(8):2350-61. doi: 10.1002/art.24680.


COX-2 and iNOS are critical in advanced glycation end product-activated chondrocytes in vitro.

Huang CY, Hung LF, Liang CC, Ho LJ.

Eur J Clin Invest. 2009 May;39(5):417-28. doi: 10.1111/j.1365-2362.2009.02106.x.


Sulforaphane inhibits TNF-alpha-induced activation of p38 MAP kinase and VCAM-1 and MCP-1 expression in endothelial cells.

Chen XL, Dodd G, Kunsch C.

Inflamm Res. 2009 Aug;58(8):513-21. doi: 10.1007/s00011-009-0017-7. Epub 2009 Mar 11.


Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells.

Hsieh CY, Hsiao HY, Wu WY, Liu CA, Tsai YC, Chao YJ, Wang DL, Hsieh HJ.

J Biomed Sci. 2009 Jan 22;16:12. doi: 10.1186/1423-0127-16-12.


Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration.

Andreas K, Häupl T, Lübke C, Ringe J, Morawietz L, Wachtel A, Sittinger M, Kaps C.

Arthritis Res Ther. 2009;11(1):R15. doi: 10.1186/ar2605. Epub 2009 Feb 3.


Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling.

Rockel JS, Bernier SM, Leask A.

Arthritis Res Ther. 2009;11(1):R8. doi: 10.1186/ar2595. Epub 2009 Jan 14.


Induction of prostacyclin by steady laminar shear stress suppresses tumor necrosis factor-alpha biosynthesis via heme oxygenase-1 in human endothelial cells.

Di Francesco L, Totani L, Dovizio M, Piccoli A, Di Francesco A, Salvatore T, Pandolfi A, Evangelista V, Dercho RA, Seta F, Patrignani P.

Circ Res. 2009 Feb 27;104(4):506-13. doi: 10.1161/CIRCRESAHA.108.191114. Epub 2009 Jan 2.


NRF2 as a determinant of cellular resistance in retinoic acid cytotoxicity.

Tan KP, Kosuge K, Yang M, Ito S.

Free Radic Biol Med. 2008 Dec 15;45(12):1663-73. doi: 10.1016/j.freeradbiomed.2008.09.010. Epub 2008 Sep 23.


Retinoid acid inhibits IL-1-induced iNOS, COX-2 and chemokine production in human chondrocytes.

Hung LF, Lai JH, Lin LC, Wang SJ, Hou TY, Chang DM, Liang CC, Ho LJ.

Immunol Invest. 2008;37(7):675-93. doi: 10.1080/08820130802307237.


4-Hydroxynonenal induces apoptosis in human osteoarthritic chondrocytes: the protective role of glutathione-S-transferase.

Vaillancourt F, Fahmi H, Shi Q, Lavigne P, Ranger P, Fernandes JC, Benderdour M.

Arthritis Res Ther. 2008;10(5):R107. doi: 10.1186/ar2503. Epub 2008 Sep 9.


Unusual transduction response of progenitor-derived and mature endothelial cells exposed to laminar pulsatile shear stress.

Daculsi R, Grellier M, Rémy M, Bareille R, Pierron D, Fernandez P, Bordenave L.

J Biomech. 2008 Aug 28;41(12):2781-5. doi: 10.1016/j.jbiomech.2008.06.003. Epub 2008 Jul 14.


Aurothiomalate inhibits COX-2 expression in chondrocytes and in human cartilage possibly through its effects on COX-2 mRNA stability.

Nieminen R, Vuolteenaho K, Riutta A, Kankaanranta H, van der Kraan PM, Moilanen T, Moilanen E.

Eur J Pharmacol. 2008 Jun 10;587(1-3):309-16. doi: 10.1016/j.ejphar.2008.03.016. Epub 2008 Mar 29.


Xanthine oxidase interaction with vascular endothelial growth factor in human endothelial cell angiogenesis.

Kou B, Ni J, Vatish M, Singer DR.

Microcirculation. 2008 Apr;15(3):251-67. doi: 10.1080/10739680701651495.


Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway.

Healy ZR, Zhu F, Stull JD, Konstantopoulos K.

Am J Physiol Cell Physiol. 2008 May;294(5):C1146-57. doi: 10.1152/ajpcell.00542.2007. Epub 2008 Mar 26.

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