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Regulation of potassium channels in coronary smooth muscle by adenoviral expression of cytochrome P-450 epoxygenase.

Campbell WB, Holmes BB, Falck JR, Capdevila JH, Gauthier KM.

Am J Physiol Heart Circ Physiol. 2006 Jan;290(1):H64-71. Epub 2005 Sep 2.


Endothelium-derived hyperpolarizing factor in human internal mammary artery is 11,12-epoxyeicosatrienoic acid and causes relaxation by activating smooth muscle BK(Ca) channels.

Archer SL, Gragasin FS, Wu X, Wang S, McMurtry S, Kim DH, Platonov M, Koshal A, Hashimoto K, Campbell WB, Falck JR, Michelakis ED.

Circulation. 2003 Feb 11;107(5):769-76.


14,15-Dihydroxyeicosatrienoic acid relaxes bovine coronary arteries by activation of K(Ca) channels.

Campbell WB, Deeter C, Gauthier KM, Ingraham RH, Falck JR, Li PL.

Am J Physiol Heart Circ Physiol. 2002 May;282(5):H1656-64.


Endothelium-independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs.

Pratt PF, Li P, Hillard CJ, Kurian J, Campbell WB.

Am J Physiol Heart Circ Physiol. 2001 Mar;280(3):H1113-21.


EETs relax airway smooth muscle via an EpDHF effect: BK(Ca) channel activation and hyperpolarization.

Benoit C, Renaudon B, Salvail D, Rousseau E.

Am J Physiol Lung Cell Mol Physiol. 2001 May;280(5):L965-73.


Regulation of BK(Ca) channels expressed in human embryonic kidney 293 cells by epoxyeicosatrienoic acid.

Fukao M, Mason HS, Kenyon JL, Horowitz B, Keef KD.

Mol Pharmacol. 2001 Jan;59(1):16-23.


Protein phosphatase 2A and Ca2+-activated K+ channels contribute to 11,12-epoxyeicosatrienoic acid analog mediated mesenteric arterial relaxation.

Dimitropoulou C, West L, Field MB, White RE, Reddy LM, Falck JR, Imig JD.

Prostaglandins Other Lipid Mediat. 2007 Feb;83(1-2):50-61. Epub 2006 Nov 7.


EET homologs potently dilate coronary microvessels and activate BK(Ca) channels.

Zhang Y, Oltman CL, Lu T, Lee HC, Dellsperger KC, VanRollins M.

Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2430-40.


Epoxyeicosatrienoic acids increase intracellular calcium concentration in vascular smooth muscle cells.

Fang X, Weintraub NL, Stoll LL, Spector AA.

Hypertension. 1999 Dec;34(6):1242-6.


Molecular characterization of an arachidonic acid epoxygenase in rat brain astrocytes.

Alkayed NJ, Narayanan J, Gebremedhin D, Medhora M, Roman RJ, Harder DR.

Stroke. 1996 May;27(5):971-9.


Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms.

Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, Lee HC.

J Physiol. 2006 Sep 1;575(Pt 2):627-44. Epub 2006 Jun 22.


Characterization of 14,15-epoxyeicosatrienoyl-sulfonamides as 14,15-epoxyeicosatrienoic acid agonists: use for studies of metabolism and ligand binding.

Yang W, Holmes BB, Gopal VR, Kishore RV, Sangras B, Yi XY, Falck JR, Campbell WB.

J Pharmacol Exp Ther. 2007 Jun;321(3):1023-31. Epub 2007 Feb 27.


14,15-epoxyeicosa-5(Z)-enoic-mSI: a 14,15- and 5,6-EET antagonist in bovine coronary arteries.

Gauthier KM, Jagadeesh SG, Falck JR, Campbell WB.

Hypertension. 2003 Oct;42(4):555-61. Epub 2003 Sep 2.


Stereospecific effects of epoxyeicosatrienoic acids on renal vascular tone and K(+)-channel activity.

Zou AP, Fleming JT, Falck JR, Jacobs ER, Gebremedhin D, Harder DR, Roman RJ.

Am J Physiol. 1996 May;270(5 Pt 2):F822-32.


Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation.

Oltman CL, Weintraub NL, VanRollins M, Dellsperger KC.

Circ Res. 1998 Nov 2;83(9):932-9.


Role of ADP-ribose in 11,12-EET-induced activation of K(Ca) channels in coronary arterial smooth muscle cells.

Li PL, Zhang DX, Ge ZD, Campbell WB.

Am J Physiol Heart Circ Physiol. 2002 Apr;282(4):H1229-36.


Endothelium-derived hyperpolarizing factor activates Ca2+-activated K+ channels in porcine coronary artery smooth muscle cells.

Hayabuchi Y, Nakaya Y, Matsuoka S, Kuroda Y.

J Cardiovasc Pharmacol. 1998 Oct;32(4):642-9.

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