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Effects of insulin-like growth factor binding protein-3 and farnesyltransferase inhibitor SCH66336 on Akt expression and apoptosis in non-small-cell lung cancer cells.

Lee HY, Moon H, Chun KH, Chang YS, Hassan K, Ji L, Lotan R, Khuri FR, Hong WK.

J Natl Cancer Inst. 2004 Oct 20;96(20):1536-48.


Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival.

Lee HY, Srinivas H, Xia D, Lu Y, Superty R, LaPushin R, Gomez-Manzano C, Gal AM, Walsh GL, Force T, Ueki K, Mills GB, Kurie JM.

J Biol Chem. 2003 Jun 27;278(26):23630-8. Epub 2003 Apr 24.


Apoptosis induced by depsipeptide FK228 coincides with inhibition of survival signaling in lung cancer cells.

Yu XD, Wang SY, Chen GA, Hou CM, Zhao M, Hong JA, Nguyen DM, Schrump DS.

Cancer J. 2007 Mar-Apr;13(2):105-13.


Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer.

Lee HY, Chun KH, Liu B, Wiehle SA, Cristiano RJ, Hong WK, Cohen P, Kurie JM.

Cancer Res. 2002 Jun 15;62(12):3530-7.


Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells.

Zhao Y, You H, Yang Y, Wei L, Zhang X, Yao L, Fan D, Yu Q.

J Cell Biochem. 2004 Feb 15;91(3):621-32.


Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer.

Bao R, Lai CJ, Wang DG, Qu H, Yin L, Zifcak B, Tao X, Wang J, Atoyan R, Samson M, Forrester J, Xu GX, DellaRocca S, Borek M, Zhai HX, Cai X, Qian C.

Mol Cancer Ther. 2009 Dec;8(12):3296-306. doi: 10.1158/1535-7163.MCT-09-0538. Epub .


Antitumor activity of selective MEK1/2 inhibitor AZD6244 in combination with PI3K/mTOR inhibitor BEZ235 in gefitinib-resistant NSCLC xenograft models.

Qu Y, Wu X, Yin Y, Yang Y, Ma D, Li H.

J Exp Clin Cancer Res. 2014 Jun 17;33:52. doi: 10.1186/1756-9966-33-52.


MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer.

Cortes-Sempere M, Chattopadhyay S, Rovira A, Rodriguez-Fanjul V, Belda-Iniesta C, Tapia M, Cejas P, Machado-Pinilla R, Manguan-García C, Sánchez-Pérez I, Nistal M, Moratilla C, de Castro-Carpeño J, Gonzalez-Barón M, Albanell J, Perona R.

Cancer Lett. 2009 Dec 28;286(2):206-16. doi: 10.1016/j.canlet.2009.05.029. Epub 2009 Jun 23.


Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells.

Kikuchi J, Kinoshita I, Shimizu Y, Oizumi S, Nishimura M, Birrer MJ, Dosaka-Akita H.

Br J Cancer. 2008 Dec 16;99(12):2013-9. doi: 10.1038/sj.bjc.6604782. Epub 2008 Nov 18.


The phosphoinositide 3-kinase/Akt pathway: a new target in human renal cell carcinoma therapy.

Sourbier C, Lindner V, Lang H, Agouni A, Schordan E, Danilin S, Rothhut S, Jacqmin D, Helwig JJ, Massfelder T.

Cancer Res. 2006 May 15;66(10):5130-42.


LY294002 and metformin cooperatively enhance the inhibition of growth and the induction of apoptosis of ovarian cancer cells.

Li C, Liu VW, Chan DW, Yao KM, Ngan HY.

Int J Gynecol Cancer. 2012 Jan;22(1):15-22. doi: 10.1097/IGC.0b013e3182322834.


Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-κB pathway in human non-small cell lung cancer.

Song L, Xiong H, Li J, Liao W, Wang L, Wu J, Li M.

Clin Cancer Res. 2011 Apr 1;17(7):1839-49. doi: 10.1158/1078-0432.CCR-10-0720. Epub 2011 Feb 15.


Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells.

Cho Y, Park MJ, Park M, Min SS, Yee J, Kim C, Han MS, Han SH.

Respirology. 2009 Aug;14(6):850-8. doi: 10.1111/j.1440-1843.2009.01563.x.


[Combined inhibition of PI3K and MEK has synergistic inhibitory effect on the proliferation of cisplatin-resistant ovarian cancer cells].

Liu Y, Chen X, Luo Z.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Jun;30(6):592-6. Chinese.


Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo.

Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ.

Mol Cancer Ther. 2002 Oct;1(12):989-97.


[Effects of PD98059 and LY294002 on subcutaneous xenograft of human endometrial carcinoma in nude mice].

Guo RX, Zhang RF, Wang XY, Shi HR, Qiao YH.

Zhonghua Fu Chan Ke Za Zhi. 2011 Jun;46(6):446-52. Chinese.

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