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16105562,16105565,16105564,16105563,16105561,16105567,16930923,16105569,15246511,16949245,19342205,20022193,18073470,18068934,24315313,17383139,15808321,19836184,18974645,18995992,18329835,16105566,23590898,19468222,16989974,15380279,19733459,16213124,18513913,15288308,18385000,10737648,16949243,16307551,16410885,17936143,15763603,16604246,28701170,16549511,17359318,15190031,17714506,10744364,19302928,16080070,18167265,21251571,18087627,20512088,30564308,19013352,16940120,19108792,18261126,22189391,17855724,20226331,17059876,26667651,19255989,12913767,15541606,15582300,11576790,16039819,18424792,15922534,18033780,20638605,16040625,18539397,22154196,17905534,20062893,20022192,16426793,18310135,17522277,16524407,16870760,21497066,19736404,16863487,17888609,23522845,19013351,18303257,16631337,18774268,16167704,18294108,18814990,15001236,16441206,22534507,19321284,19302927,16626904,3477332,9164012,21051375,23514757,19554486,20930043,16326811,15555879,19501791,22770774,19167827,15081092,21875338,15150179,17005838,23979759,15808320,15494811,21619494,2822054,15679482,15664479,15135503,24304986,11501295,10862291,27216271,14972384,21353964,19123310,24582580,15175611,20067876,20361999,24103203,15128723,19919286,22104303,19883155,16801403,19913682,15991478,16189097,20159376,15935606,7753690,15559195,11892893,15313534,22258926,15766607,17494717,16105560,20727474,17606689,27291285,22078909,30445209,25791941,19567346,9661018,10476719,29338931,19567345,15737510,27504548,16080069,15951353,23856111,21513809,28951056,19219281,23546465,25653413,19402288,9491183,20955916,3100147,24055218,24562613,24492361,21347680,15013041,9987189,25748553,15964502,16105559,25456893,21309205,12493175,17620376,27504550,10522430,15784308,6486756,11008707,3264166,9185414,9876206,27599998,15266809,14985278,7973153,10212756,25583717,19535842,10530454,12415474,1528143,8907383,22335615,19028618,21524975,15113321,15916040,29679648,17931820,15313533,16048932,15330324,15849049,15720512,32040455,23514756,30611932,24505091,15793128,29395713,15081085,18716808,18077902,26704158,26024284,27530839,23127485,15452398,14987822,31161033,27343986,16024592,21664110,21129924,19621605,25294303,11589478,19423466,18802728,11712965,21180392,15028663,21453736,21861004,30808530,15711674,11502382,22524597,9420050,15973011,24342717,23183481,27347770,23678070,24821320,8622113,16940056,12003983,23134658,10092967,25958201,22655469,12967754,24125508,20600430,21425595,12805264,28257904,15878446,15572192,31843997,21118915,20431506,15722390,7498618,8361411,27197104,9379467,11136768,27352729,3256508,10626138,12730001,14593898,18443115,15380281,15201229,21771509,19028619,16048970,30373806,11516938,9823530,11105151,1767256,23221186,27539221,15737475,17987230,10863109,23868576,21353958,8195834,12121938,12088620,24649797,28406770,11793839,23228934,19763644,10826834,27013000,8290899,14510147,32049591,29895051,28748397,26124155,15808317,26008659,7649189,21887800,11850282,11528564,11836882,24006892,21045403,11709353,20082037,32623972,15793159,16098786,22030102,29294031,24440509,28159446,23057259,26682961,19064899,14743981,1481545,14702671,24194558,22276442,20022936,10898710,11858912,15558355,22358396,15824092,20435576,12838659,15959998,15916088,16127069,8988765,19208884,16433594,22805658,26892779,19589276,18390405,11450881,26794819,11001329,24118469,24091308,16285353,28124025,18676218,12432483,20846936,9688200,25409355,12525919,16127070,20045291,27077933,28929962,19621154,22197193,10705052,23826912,20368399,15480665,15869868,14740788,20100118,25179867,15949926,23982472,18363469,12052630,15000555,9705857,24288110,17093026,16389407,12959687,22689029,24377177,19931812,23461830,21577055,20592149,23979750,20496091,18191514,19242083,24120834,10991855,15214884,30735325,16167515,22431850,11349593,15980394,29939129,18443122,14732307,7699427,15463901,11714050,9769905,23683574,15341251,20571291,20966554,2499564,14509942,29305546,12884158,30580624,25607829,12878532,22238441,9069549,8203851,23458769,10768062,22130574,30672894,16012006,9184355,11463523,12499224,2626104,28920854,17954694,12503932,1601752,11516931,21606223,29620805,15810502,27210872,29307862,11573320,34354138,11816830,12597553,2228831,27000866,11998386,28985401,26098395,20602895,27004323,9468728,14593897,17684638,11714043,30690539,18382151,30096417,27917692,22975168,10755240,18725451,12706616,12575239,26415906,10222843,17005820,8191243,26596030,10221421,16502985,15729490,24287463,11330359,1424522,20929376,10197036,17119701,11801996,15780894,34225485,10926444,16024591,24470884,18474585,22397044,27742200,15105768,10765030,1459058,35831935,21911982,1767255,20461296,17536927,33743369,6327506,15013046,26814180,8004048,21735843,29178851,2575103,25324419,1624399,10722519,19441651,25963338,25111928,16094559,11307327,9669651,24080651,9145899,10722495,10618141,25232168,31119576,9332178,27434956,2127270,1848461,26083738,15712558,8067744,3579247,9151198,19296137,11887338,21670904,28651522,27873686,11085445,32376058,16569883,8486582,11866719,11864130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Page 1

Tigecycline activity tested against 26,474 bloodstream infection isolates: a collection from 6 continents.

Sader HS, Jones RN, Stilwell MG, Dowzicky MJ, Fritsche TR. Sader HS, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):181-6. doi: 10.1016/j.diagmicrobio.2005.05.005. Diagn Microbiol Infect Dis. 2005. PMID: 16105562

Antimicrobial activity of tigecycline tested against nosocomial bacterial pathogens from patients hospitalized in the intensive care unit.

Sader HS, Jones RN, Dowzicky MJ, Fritsche TR. Sader HS, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):203-8. doi: 10.1016/j.diagmicrobio.2005.05.002. Diagn Microbiol Infect Dis. 2005. PMID: 16105565

Potency and spectrum of tigecycline tested against an international collection of bacterial pathogens associated with skin and soft tissue infections (2000-2004).

Fritsche TR, Sader HS, Stilwell MG, Dowzicky MJ, Jones RN. Fritsche TR, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):195-201. doi: 10.1016/j.diagmicrobio.2005.05.003. Diagn Microbiol Infect Dis. 2005. PMID: 16105564

Antimicrobial activity of tigecycline tested against organisms causing community-acquired respiratory tract infection and nosocomial pneumonia.

Fritsche TR, Sader HS, Stilwell MG, Dowzicky MJ, Jones RN. Fritsche TR, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):187-93. doi: 10.1016/j.diagmicrobio.2005.05.004. Diagn Microbiol Infect Dis. 2005. PMID: 16105563

In vitro activity of tigecycline against 3989 Gram-negative and Gram-positive clinical isolates from the United States Tigecycline Evaluation and Surveillance Trial (TEST Program; 2004).

Bouchillon SK, Hoban DJ, Johnson BM, Johnson JL, Hsiung A, Dowzicky MJ; Tigecycline Evaluation and Surveillance Trial (TEST) Group. Bouchillon SK, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):173-9. doi: 10.1016/j.diagmicrobio.2005.06.004. Diagn Microbiol Infect Dis. 2005. PMID: 16105561

In vitro activity of tigecycline against 6792 Gram-negative and Gram-positive clinical isolates from the global Tigecycline Evaluation and Surveillance Trial (TEST Program, 2004).

Hoban DJ, Bouchillon SK, Johnson BM, Johnson JL, Dowzicky MJ; Tigecycline Evaluation and Surveillance Trial (TEST Program) Group. Hoban DJ, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):215-27. doi: 10.1016/j.diagmicrobio.2005.06.001. Diagn Microbiol Infect Dis. 2005. PMID: 16105567

Comparisons of parenteral broad-spectrum cephalosporins tested against bacterial isolates from pediatric patients: report from the SENTRY Antimicrobial Surveillance Program (1998-2004).

Jones RN, Sader HS, Fritsche TR, Pottumarthy S. Jones RN, et al. Diagn Microbiol Infect Dis. 2007 Jan;57(1):109-16. doi: 10.1016/j.diagmicrobio.2006.06.011. Epub 2006 Aug 23. Diagn Microbiol Infect Dis. 2007. PMID: 16930923

Potency and spectrum trends for cefepime tested against 65746 clinical bacterial isolates collected in North American medical centers: results from the SENTRY Antimicrobial Surveillance Program (1998-2003).

Sader HS, Fritsche TR, Jones RN. Sader HS, et al. Diagn Microbiol Infect Dis. 2005 Jul;52(3):265-73. doi: 10.1016/j.diagmicrobio.2005.02.003. Diagn Microbiol Infect Dis. 2005. PMID: 16105569

In vitro activity of tigecycline (GAR-936) tested against 11,859 recent clinical isolates associated with community-acquired respiratory tract and gram-positive cutaneous infections.

Fritsche TR, Kirby JT, Jones RN. Fritsche TR, et al. Diagn Microbiol Infect Dis. 2004 Jul;49(3):201-9. doi: 10.1016/j.diagmicrobio.2004.03.002. Diagn Microbiol Infect Dis. 2004. PMID: 15246511

Antimicrobial activity of tigecycline against clinical isolates from Spanish medical centers. Second multicenter study.

Betriu C, Rodríguez-Avial I, Gómez M, Culebras E, López F, Alvarez J, Picazo JJ; Spanish Tigecycline Group. Betriu C, et al. Diagn Microbiol Infect Dis. 2006 Dec;56(4):437-44. doi: 10.1016/j.diagmicrobio.2006.07.005. Epub 2006 Sep 1. Diagn Microbiol Infect Dis. 2006. PMID: 16949245

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