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Results: 1 to 20 of 219

1.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, Ratcliffe PJ, Linehan WM, Neckers L.

Cancer Cell. 2005 Aug;8(2):143-53.

PMID:
16098467
[PubMed - indexed for MEDLINE]
Free Article
2.

Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2, and "cryptic targets" of transcription factors.

Ooi A, Furge KA.

Chin J Cancer. 2012 Sep;31(9):413-20. doi: 10.5732/cjc.012.10102. Epub 2012 Jul 2. Review.

PMID:
22776233
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Fumarase: a mitochondrial metabolic enzyme and a cytosolic/nuclear component of the DNA damage response.

Yogev O, Yogev O, Singer E, Shaulian E, Goldberg M, Fox TD, Pines O.

PLoS Biol. 2010 Mar 9;8(3):e1000328. doi: 10.1371/journal.pbio.1000328.

PMID:
20231875
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion.

Sudarshan S, Shanmugasundaram K, Naylor SL, Lin S, Livi CB, O'Neill CF, Parekh DJ, Yeh IT, Sun LZ, Block K.

PLoS One. 2011;6(6):e21037. doi: 10.1371/journal.pone.0021037. Epub 2011 Jun 14.

PMID:
21695080
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

Sudarshan S, Sourbier C, Kong HS, Block K, Valera Romero VA, Yang Y, Galindo C, Mollapour M, Scroggins B, Goode N, Lee MJ, Gourlay CW, Trepel J, Linehan WM, Neckers L.

Mol Cell Biol. 2009 Aug;29(15):4080-90. doi: 10.1128/MCB.00483-09. Epub 2009 May 26.

PMID:
19470762
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Identification of novel VHL target genes and relationship to hypoxic response pathways.

Maina EN, Morris MR, Zatyka M, Raval RR, Banks RE, Richards FM, Johnson CM, Maher ER.

Oncogene. 2005 Jun 30;24(28):4549-58.

PMID:
15824735
[PubMed - indexed for MEDLINE]
7.

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

Raval RR, Lau KW, Tran MG, Sowter HM, Mandriota SJ, Li JL, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ.

Mol Cell Biol. 2005 Jul;25(13):5675-86.

PMID:
15964822
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway.

Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP.

Cancer Cell. 2007 Apr;11(4):311-9.

PMID:
17418408
[PubMed - indexed for MEDLINE]
Free Article
10.

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF.

Koivunen P, Hirsilä M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J.

J Biol Chem. 2007 Feb 16;282(7):4524-32. Epub 2006 Dec 19.

PMID:
17182618
[PubMed - indexed for MEDLINE]
Free Article
11.

UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.

Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, Abu-Asab MS, Bratslavsky G, Tsokos M, Merino MJ, Pinto PA, Srinivasan R, Ried T, Neckers L, Linehan WM.

Cancer Genet Cytogenet. 2010 Jan 1;196(1):45-55. doi: 10.1016/j.cancergencyto.2009.08.018.

PMID:
19963135
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Fumarate hydratase deficiency and cancer: activation of hypoxia signaling?

Ratcliffe PJ.

Cancer Cell. 2007 Apr;11(4):303-5.

PMID:
17418405
[PubMed - indexed for MEDLINE]
Free Article
13.

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor.

Hirsilä M, Koivunen P, Günzler V, Kivirikko KI, Myllyharju J.

J Biol Chem. 2003 Aug 15;278(33):30772-80. Epub 2003 Jun 3.

PMID:
12788921
[PubMed - indexed for MEDLINE]
Free Article
14.

Molecular genetic analysis of FIH-1, FH, and SDHB candidate tumour suppressor genes in renal cell carcinoma.

Morris MR, Maina E, Morgan NV, Gentle D, Astuti D, Moch H, Kishida T, Yao M, Schraml P, Richards FM, Latif F, Maher ER.

J Clin Pathol. 2004 Jul;57(7):706-11.

PMID:
15220362
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Expression of hypoxia inducible factor-1alpha and 2alpha in genetically distinct early renal cortical tumors.

Kim CM, Vocke C, Torres-Cabala C, Yang Y, Schmidt L, Walther M, Linehan WM.

J Urol. 2006 May;175(5):1908-14.

PMID:
16600797
[PubMed - indexed for MEDLINE]
16.

Missense mutations in fumarate hydratase in multiple cutaneous and uterine leiomyomatosis and renal cell cancer.

Alam NA, Olpin S, Rowan A, Kelsell D, Leigh IM, Tomlinson IP, Weaver T.

J Mol Diagn. 2005 Oct;7(4):437-43.

PMID:
16237213
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Increased HIF1 alpha in SDH and FH deficient tumors does not cause microsatellite instability.

Lehtonen HJ, Mäkinen MJ, Kiuru M, Laiho P, Herva R, van Minderhout I, Hogendoorn PC, Cornelisse C, Devilee P, Launonen V, Aaltonen LA.

Int J Cancer. 2007 Sep 15;121(6):1386-9.

PMID:
17520677
[PubMed - indexed for MEDLINE]
18.

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron.

Mandriota SJ, Turner KJ, Davies DR, Murray PG, Morgan NV, Sowter HM, Wykoff CC, Maher ER, Harris AL, Ratcliffe PJ, Maxwell PH.

Cancer Cell. 2002 Jun;1(5):459-68.

PMID:
12124175
[PubMed - indexed for MEDLINE]
Free Article
19.

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

Sowter HM, Raval RR, Moore JW, Ratcliffe PJ, Harris AL.

Cancer Res. 2003 Oct 1;63(19):6130-4. Erratum in: Cancer Res. 2003 Dec 1;63(23):8562.

PMID:
14559790
[PubMed - indexed for MEDLINE]
Free Article
20.

An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma.

Ooi A, Wong JC, Petillo D, Roossien D, Perrier-Trudova V, Whitten D, Min BW, Tan MH, Zhang Z, Yang XJ, Zhou M, Gardie B, Molinié V, Richard S, Tan PH, Teh BT, Furge KA.

Cancer Cell. 2011 Oct 18;20(4):511-23. doi: 10.1016/j.ccr.2011.08.024.

PMID:
22014576
[PubMed - indexed for MEDLINE]
Free Article

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