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Results: 1 to 20 of 121

1.

Second nature: biological functions of the Raf-1 "kinase".

Baccarini M.

FEBS Lett. 2005 Jun 13;579(15):3271-7. Epub 2005 Mar 23. Review.

PMID:
15943972
[PubMed - indexed for MEDLINE]
Free Article
2.

Extracellular signal regulated kinase (ERK)/mitogen activated protein kinase (MAPK)-independent functions of Raf kinases.

Hindley A, Kolch W.

J Cell Sci. 2002 Apr 15;115(Pt 8):1575-81. Review.

PMID:
11950876
[PubMed - indexed for MEDLINE]
Free Article
3.

Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

Yang R, Piperdi S, Gorlick R.

Clin Cancer Res. 2008 Oct 15;14(20):6396-404. doi: 10.1158/1078-0432.CCR-07-5113.

PMID:
18927278
[PubMed - indexed for MEDLINE]
Free Article
4.

Raf-1 kinase activation is uncoupled from downstream MEK/ERK pathway in cells treated with Src tyrosine kinase inhibitor PP2.

Lee M.

Biochem Biophys Res Commun. 2006 Nov 17;350(2):450-6. Epub 2006 Sep 22.

PMID:
17010316
[PubMed - indexed for MEDLINE]
5.

The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

Li M, Ong SS, Rajwa B, Thieu VT, Geahlen RL, Harrison ML.

Mol Cell Biol. 2008 Jan;28(2):630-41. Epub 2007 Nov 12.

PMID:
17998336
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.

Hatzivassiliou G, Song K, Yen I, Brandhuber BJ, Anderson DJ, Alvarado R, Ludlam MJ, Stokoe D, Gloor SL, Vigers G, Morales T, Aliagas I, Liu B, Sideris S, Hoeflich KP, Jaiswal BS, Seshagiri S, Koeppen H, Belvin M, Friedman LS, Malek S.

Nature. 2010 Mar 18;464(7287):431-5. doi: 10.1038/nature08833. Epub 2010 Feb 3.

PMID:
20130576
[PubMed - indexed for MEDLINE]
7.

Raf-1 without MEK?

Murakami MS, Morrison DK.

Sci STKE. 2001 Sep 11;2001(99):pe30.

PMID:
11579234
[PubMed - indexed for MEDLINE]
8.

Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3.

PMID:
19258520
[PubMed - indexed for MEDLINE]
Free Article
9.

Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release.

Kumar P, Coltas IK, Kumar B, Chepeha DB, Bradford CR, Polverini PJ.

Cancer Res. 2007 Feb 1;67(3):1193-202.

PMID:
17283155
[PubMed - indexed for MEDLINE]
Free Article
10.

Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer.

Roberts PJ, Der CJ.

Oncogene. 2007 May 14;26(22):3291-310. Review.

PMID:
17496923
[PubMed - indexed for MEDLINE]
11.

The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.

Schulze A, Nicke B, Warne PH, Tomlinson S, Downward J.

Mol Biol Cell. 2004 Jul;15(7):3450-63. Epub 2004 Apr 16.

PMID:
15090615
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Coordinating ERK/MAPK signalling through scaffolds and inhibitors.

Kolch W.

Nat Rev Mol Cell Biol. 2005 Nov;6(11):827-37. Review.

PMID:
16227978
[PubMed - indexed for MEDLINE]
13.

Cell type-specific importance of ras-c-raf complex association rate constants for MAPK signaling.

Kiel C, Serrano L.

Sci Signal. 2009 Jul 28;2(81):ra38. doi: 10.1126/scisignal.2000397.

PMID:
19638615
[PubMed - indexed for MEDLINE]
Free Article
14.

Protein kinase C alpha trigger Ras and Raf-independent MEK/ERK activation for TPA-induced growth inhibition of human hepatoma cell HepG2.

Wen-Sheng W.

Cancer Lett. 2006 Jul 28;239(1):27-35. Epub 2005 Sep 19.

PMID:
16169661
[PubMed - indexed for MEDLINE]
15.

Raf kinases in cancer-roles and therapeutic opportunities.

Maurer G, Tarkowski B, Baccarini M.

Oncogene. 2011 Aug 11;30(32):3477-88. doi: 10.1038/onc.2011.160. Epub 2011 May 16. Review.

PMID:
21577205
[PubMed - indexed for MEDLINE]
16.

Regulation of the Raf-MEK-ERK pathway by protein phosphatase 5.

von Kriegsheim A, Pitt A, Grindlay GJ, Kolch W, Dhillon AS.

Nat Cell Biol. 2006 Sep;8(9):1011-6. Epub 2006 Aug 6.

PMID:
16892053
[PubMed - indexed for MEDLINE]
17.

The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells.

Noser JA, Mael AA, Sakuma R, Ohmine S, Marcato P, Lee PW, Ikeda Y.

Mol Ther. 2007 Aug;15(8):1531-6. Epub 2007 May 15.

PMID:
17505473
[PubMed - indexed for MEDLINE]
18.

Raf: a strategic target for therapeutic development against cancer.

Beeram M, Patnaik A, Rowinsky EK.

J Clin Oncol. 2005 Sep 20;23(27):6771-90. Review.

PMID:
16170185
[PubMed - indexed for MEDLINE]
Free Article
19.

Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells.

Kwon DS, Kwon CH, Kim JH, Woo JS, Jung JS, Kim YK.

Eur J Cell Biol. 2006 Nov;85(11):1189-99. Epub 2006 Jul 24.

PMID:
16860436
[PubMed - indexed for MEDLINE]
20.

A loss-of-function screen reveals Ras- and Raf-independent MEK-ERK signaling during Chlamydia trachomatis infection.

Gurumurthy RK, Mäurer AP, Machuy N, Hess S, Pleissner KP, Schuchhardt J, Rudel T, Meyer TF.

Sci Signal. 2010 Mar 16;3(113):ra21. doi: 10.1126/scisignal.2000651.

PMID:
20234004
[PubMed - indexed for MEDLINE]
Free Article

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