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Items: 1 to 20 of 112

1.

Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition.

Harwood HJ Jr.

Expert Opin Ther Targets. 2005 Apr;9(2):267-81. Review.

PMID:
15934915
2.

Acetyl-CoA carboxylase inhibition for the treatment of metabolic syndrome.

Harwood HJ Jr.

Curr Opin Investig Drugs. 2004 Mar;5(3):283-9. Review.

PMID:
15083594
3.

Inhibitors of mammalian acetyl-CoA carboxylase.

Corbett JW, Harwood JH Jr.

Recent Pat Cardiovasc Drug Discov. 2007 Nov;2(3):162-80. Review.

PMID:
18221116
4.

Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals.

Harwood HJ Jr, Petras SF, Shelly LD, Zaccaro LM, Perry DA, Makowski MR, Hargrove DM, Martin KA, Tracey WR, Chapman JG, Magee WP, Dalvie DK, Soliman VF, Martin WH, Mularski CJ, Eisenbeis SA.

J Biol Chem. 2003 Sep 26;278(39):37099-111. Epub 2003 Jul 3.

5.

Regulatory enzymes of mitochondrial beta-oxidation as targets for treatment of the metabolic syndrome.

Schreurs M, Kuipers F, van der Leij FR.

Obes Rev. 2010 May;11(5):380-8. doi: 10.1111/j.1467-789X.2009.00642.x. Epub 2009 Aug 20. Review.

PMID:
19694967
6.

A herbal extract with acetyl-coenzyme A carboxylase inhibitory activity and its potential for treating metabolic syndrome.

Chen CH, Chang MY, Lin YS, Lin DG, Chen SW, Chao PM.

Metabolism. 2009 Sep;58(9):1297-305. doi: 10.1016/j.metabol.2009.04.012. Epub 2009 Jun 18.

PMID:
19500808
7.

Modulation of fatty acid metabolism as a potential approach to the treatment of obesity and the metabolic syndrome.

Kusunoki J, Kanatani A, Moller DE.

Endocrine. 2006 Feb;29(1):91-100. Review.

PMID:
16622296
8.

Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008.

Corbett JW.

Expert Opin Ther Pat. 2009 Jul;19(7):943-56. doi: 10.1517/13543770902862180. Review.

PMID:
19552511
9.

Acetyl-CoA carboxylase-a as a novel target for cancer therapy.

Wang C, Rajput S, Watabe K, Liao DF, Cao D.

Front Biosci (Schol Ed). 2010 Jan 1;2:515-26. Review.

PMID:
20036965
10.

Gene expression analysis in rats treated with experimental acetyl-coenzyme A carboxylase inhibitors suggests interactions with the peroxisome proliferator-activated receptor alpha pathway.

Waring JF, Yang Y, Healan-Greenberg CH, Adler AL, Dickinson R, McNally T, Wang X, Weitzberg M, Xu X, Lisowski A, Warder SE, Gu YG, Zinker BA, Blomme EA, Camp HS.

J Pharmacol Exp Ther. 2008 Feb;324(2):507-16. Epub 2007 Nov 19.

11.

Cyclohexanedione herbicides are inhibitors of rat heart acetyl-CoA carboxylase.

Seng TW, Skillman TR, Yang N, Hammond C.

Bioorg Med Chem Lett. 2003 Oct 6;13(19):3237-42.

PMID:
12951100
12.

Expression, purification, and characterization of human and rat acetyl coenzyme A carboxylase (ACC) isozymes.

Cheng D, Chu CH, Chen L, Feder JN, Mintier GA, Wu Y, Cook JW, Harpel MR, Locke GA, An Y, Tamura JK.

Protein Expr Purif. 2007 Jan;51(1):11-21. Epub 2006 Jun 10.

PMID:
16854592
13.

Role of malonyl-CoA in heart disease and the hypothalamic control of obesity.

Folmes CD, Lopaschuk GD.

Cardiovasc Res. 2007 Jan 15;73(2):278-87. Epub 2006 Oct 20. Review.

14.

Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats.

Bengtsson C, Blaho S, Saitton DB, Brickmann K, Broddefalk J, Davidsson O, Drmota T, Folmer R, Hallberg K, Hallén S, Hovland R, Isin E, Johannesson P, Kull B, Larsson LO, Löfgren L, Nilsson KE, Noeske T, Oakes N, Plowright AT, Schnecke V, Ståhlberg P, Sörme P, Wan H, Wellner E, Oster L.

Bioorg Med Chem. 2011 May 15;19(10):3039-53. doi: 10.1016/j.bmc.2011.04.014. Epub 2011 Apr 13.

PMID:
21515056
15.

(4-Piperidinyl)-piperazine: a new platform for acetyl-CoA carboxylase inhibitors.

Chonan T, Oi T, Yamamoto D, Yashiro M, Wakasugi D, Tanaka H, Ohoka-Sugita A, Io F, Koretsune H, Hiratate A.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6645-8. doi: 10.1016/j.bmcl.2009.10.012. Epub 2009 Oct 8.

PMID:
19853443
16.

Structure, function and selective inhibition of bacterial acetyl-coa carboxylase.

Polyak SW, Abell AD, Wilce MC, Zhang L, Booker GW.

Appl Microbiol Biotechnol. 2012 Feb;93(3):983-92. doi: 10.1007/s00253-011-3796-z. Epub 2011 Dec 20. Review.

PMID:
22183085
17.

Inhibition of acetyl-CoA carboxylase isoforms by pyridoxal phosphate.

Lee WM, Elliott JE, Brownsey RW.

J Biol Chem. 2005 Dec 23;280(51):41835-43. Epub 2005 Oct 25.

18.

Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.

Zhou L, Huang H, Yuan CL, Keung W, Lopaschuk GD, Stanley WC.

Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H954-60. Epub 2007 Dec 14.

19.

Targeting acetyl-CoA carboxylases: small molecular inhibitors and their therapeutic potential.

Luo DX, Tong DJ, Rajput S, Wang C, Liao DF, Cao D, Maser E.

Recent Pat Anticancer Drug Discov. 2012 May 1;7(2):168-84. Review.

PMID:
22339356
20.
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