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Results: 1 to 20 of 119

1.

The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).

Garcia-Calvo M, Lisnock J, Bull HG, Hawes BE, Burnett DA, Braun MP, Crona JH, Davis HR Jr, Dean DC, Detmers PA, Graziano MP, Hughes M, Macintyre DE, Ogawa A, O'neill KA, Iyer SP, Shevell DE, Smith MM, Tang YS, Makarewicz AM, Ujjainwalla F, Altmann SW, Chapman KT, Thornberry NA.

Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132-7. Epub 2005 May 31.

PMID:
15928087
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane.

Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H.

Biochim Biophys Acta. 2007 Sep;1771(9):1140-7. Epub 2007 Jun 23.

PMID:
17689140
[PubMed - indexed for MEDLINE]
Free Article
3.

In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.

Hawes BE, O'neill KA, Yao X, Crona JH, Davis HR Jr, Graziano MP, Altmann SW.

Mol Pharmacol. 2007 Jan;71(1):19-29. Epub 2006 Sep 27.

PMID:
17005902
[PubMed - indexed for MEDLINE]
Free Article
4.

Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption.

Altmann SW, Davis HR Jr, Zhu LJ, Yao X, Hoos LM, Tetzloff G, Iyer SP, Maguire M, Golovko A, Zeng M, Wang L, Murgolo N, Graziano MP.

Science. 2004 Feb 20;303(5661):1201-4.

PMID:
14976318
[PubMed - indexed for MEDLINE]
Free Article
5.

Extracellular loop C of NPC1L1 is important for binding to ezetimibe.

Weinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML.

Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11140-5. doi: 10.1073/pnas.0800936105. Epub 2008 Aug 5.

PMID:
18682566
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Ezetimibe restores biliary cholesterol excretion in mice expressing Niemann-Pick C1-Like 1 only in liver.

Tang W, Jia L, Ma Y, Xie P, Haywood J, Dawson PA, Li J, Yu L.

Biochim Biophys Acta. 2011 Sep;1811(9):549-55. doi: 10.1016/j.bbalip.2011.05.013. Epub 2011 Jun 12.

PMID:
21683156
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Ezetimibe blocks the internalization of NPC1L1 and cholesterol in mouse small intestine.

Xie C, Zhou ZS, Li N, Bian Y, Wang YJ, Wang LJ, Li BL, Song BL.

J Lipid Res. 2012 Oct;53(10):2092-101. Epub 2012 Jul 17.

PMID:
22811412
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles.

Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY.

Biochim Biophys Acta. 2007 Sep;1771(9):1132-9. Epub 2007 Mar 16.

PMID:
17442616
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Transporters as drug targets: discovery and development of NPC1L1 inhibitors.

Betters JL, Yu L.

Clin Pharmacol Ther. 2010 Jan;87(1):117-21. doi: 10.1038/clpt.2009.209. Epub 2009 Nov 11. Review. Erratum in: Clin Pharmacol Ther. 2010 Jun;87(6):759.

PMID:
19907422
[PubMed - indexed for MEDLINE]
10.

Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe.

Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L.

J Clin Invest. 2007 Jul;117(7):1968-78.

PMID:
17571164
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

NPC1L1 and cholesterol transport.

Betters JL, Yu L.

FEBS Lett. 2010 Jul 2;584(13):2740-7. doi: 10.1016/j.febslet.2010.03.030. Epub 2010 Mar 19. Review.

PMID:
20307540
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter.

Davis HR Jr, Altmann SW.

Biochim Biophys Acta. 2009 Jul;1791(7):679-83. doi: 10.1016/j.bbalip.2009.01.002. Epub 2009 Jan 19. Review.

PMID:
19272334
[PubMed - indexed for MEDLINE]
Free Article
13.

Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia.

Davis HR, Veltri EP.

J Atheroscler Thromb. 2007 Jun;14(3):99-108. Review.

PMID:
17587760
[PubMed - indexed for MEDLINE]
Free Article
14.

Ezetimibe inhibits hepatic Niemann-Pick C1-Like 1 to facilitate macrophage reverse cholesterol transport in mice.

Xie P, Jia L, Ma Y, Ou J, Miao H, Wang N, Guo F, Yazdanyar A, Jiang XC, Yu L.

Arterioscler Thromb Vasc Biol. 2013 May;33(5):920-5. doi: 10.1161/ATVBAHA.112.301187. Epub 2013 Mar 7.

PMID:
23471229
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-induced internalization of NPC1L1.

Ge L, Wang J, Qi W, Miao HH, Cao J, Qu YX, Li BL, Song BL.

Cell Metab. 2008 Jun;7(6):508-19. doi: 10.1016/j.cmet.2008.04.001.

PMID:
18522832
[PubMed - indexed for MEDLINE]
Free Article
16.

Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake.

Ge L, Qi W, Wang LJ, Miao HH, Qu YX, Li BL, Song BL.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):551-6. doi: 10.1073/pnas.1014434108. Epub 2010 Dec 27.

PMID:
21187433
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Human NPC1L1 expression is positively regulated by PPARα.

Iwayanagi Y, Takada T, Tomura F, Yamanashi Y, Terada T, Inui K, Suzuki H.

Pharm Res. 2011 Feb;28(2):405-12. doi: 10.1007/s11095-010-0294-4. Epub 2010 Oct 16.

PMID:
20953676
[PubMed - indexed for MEDLINE]
18.

Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1).

Davis HR Jr, Basso F, Hoos LM, Tetzloff G, Lally SM, Altmann SW.

Atheroscler Suppl. 2008 Sep;9(2):77-81. doi: 10.1016/j.atherosclerosissup.2008.05.008. Epub 2008 Jun 27. Review.

PMID:
18585981
[PubMed - indexed for MEDLINE]
19.

Ezetimibe, a selective inhibitor of the transport of cholesterol.

Miura S, Saku K.

Intern Med. 2008;47(13):1165-70. Epub 2008 Jul 1. Review.

PMID:
18591835
[PubMed - indexed for MEDLINE]
Free Article
20.

[Genetic background of the efficacy of cholesterol absorption. The role of Niemann-Pick C1-like 1 receptor and its genetic variations in lipid metabolism].

Harangi M, Balogh I, Harangi J, Paragh G.

Orv Hetil. 2010 Aug 22;151(34):1376-83. doi: 10.1556/OH.2010.28933. Hungarian.

PMID:
20705552
[PubMed - indexed for MEDLINE]
Free Article

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