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Items: 1 to 20 of 154


Intramolecular regulatory switch in ZAP-70: analogy with receptor tyrosine kinases.

Brdicka T, Kadlecek TA, Roose JP, Pastuszak AW, Weiss A.

Mol Cell Biol. 2005 Jun;25(12):4924-33.


Phosphorylation of Tyr319 in ZAP-70 is required for T-cell antigen receptor-dependent phospholipase C-gamma1 and Ras activation.

Williams BL, Irvin BJ, Sutor SL, Chini CC, Yacyshyn E, Bubeck Wardenburg J, Dalton M, Chan AC, Abraham RT.

EMBO J. 1999 Apr 1;18(7):1832-44.


Interdomain B in ZAP-70 regulates but is not required for ZAP-70 signaling function in lymphocytes.

Zhao Q, Williams BL, Abraham RT, Weiss A.

Mol Cell Biol. 1999 Jan;19(1):948-56.


Activation of Zap-70 tyrosine kinase due to a structural rearrangement induced by tyrosine phosphorylation and/or ITAM binding.

Visco C, Magistrelli G, Bosotti R, Perego R, Rusconi L, Toma S, Zamai M, Acuto O, Isacchi A.

Biochemistry. 2000 Mar 14;39(10):2784-91.


Regulation of T-cell antigen receptor signalling by Syk tyrosine protein kinase.

Latour S, Fournel M, Veillette A.

Mol Cell Biol. 1997 Aug;17(8):4434-41.


Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1.

Brockdorff J, Williams S, Couture C, Mustelin T.

Eur J Immunol. 1999 Aug;29(8):2539-50.


The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains.

Woodside DG, Obergfell A, Talapatra A, Calderwood DA, Shattil SJ, Ginsberg MH.

J Biol Chem. 2002 Oct 18;277(42):39401-8. Epub 2002 Aug 8.


T cell activation induced by novel gain-of-function mutants of Syk and ZAP-70.

Zeitlmann L, Knorr T, Knoll M, Romeo C, Sirim P, Kolanus W.

J Biol Chem. 1998 Jun 19;273(25):15445-52.


Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex.

Thome M, Duplay P, Guttinger M, Acuto O.

J Exp Med. 1995 Jun 1;181(6):1997-2006.


Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is required for T-cell receptor function.

Bubeck Wardenburg J, Fu C, Jackman JK, Flotow H, Wilkinson SE, Williams DH, Johnson R, Kong G, Chan AC, Findell PR.

J Biol Chem. 1996 Aug 16;271(33):19641-4.


Reconstitution of T cell antigen receptor-induced Erk2 kinase activation in Lck-negative JCaM1 cells by Syk.

Williams S, Couture C, Gilman J, Jascur T, Deckert M, Altman A, Mustelin T.

Eur J Biochem. 1997 Apr 1;245(1):84-90.


Reconstitution of Syk function by the ZAP-70 protein tyrosine kinase.

Kong GH, Bu JY, Kurosaki T, Shaw AS, Chan AC.

Immunity. 1995 May;2(5):485-92.


Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.

Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT.

Mol Cell Biol. 1998 Mar;18(3):1388-99.


Alternative antigen receptor (TCR) signaling in T cells derived from ZAP-70-deficient patients expressing high levels of Syk.

Noraz N, Schwarz K, Steinberg M, Dardalhon V, Rebouissou C, Hipskind R, Friedrich W, Yssel H, Bacon K, Taylor N.

J Biol Chem. 2000 May 26;275(21):15832-8.


Differential expression of ZAP-70 and Syk protein tyrosine kinases, and the role of this family of protein tyrosine kinases in TCR signaling.

Chan AC, van Oers NS, Tran A, Turka L, Law CL, Ryan JC, Clark EA, Weiss A.

J Immunol. 1994 May 15;152(10):4758-66.

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