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Results: 1 to 20 of 124

1.

2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists.

Feng DM, Wai JM, Kuduk SD, Ng C, Murphy KL, Ransom RW, Reiss D, Chang RS, Harrell CM, MacNeil T, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2005 May 2;15(9):2385-8.

PMID:
15837330
[PubMed - indexed for MEDLINE]
2.

2,3-diaminopyridine bradykinin B1 receptor antagonists.

Kuduk SD, Ng C, Feng DM, Wai JM, Chang RS, Harrell CM, Murphy KL, Ransom RW, Reiss D, Ivarsson M, Mason G, Boyce S, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

J Med Chem. 2004 Dec 16;47(26):6439-42.

PMID:
15588075
[PubMed - indexed for MEDLINE]
3.

Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists.

Wood MR, Schirripa KM, Kim JJ, Wan BL, Murphy KL, Ransom RW, Chang RS, Tang C, Prueksaritanont T, Detwiler TJ, Hettrick LA, Landis ER, Leonard YM, Krueger JA, Lewis SD, Pettibone DJ, Freidinger RM, Bock MG.

J Med Chem. 2006 Feb 23;49(4):1231-4.

PMID:
16480259
[PubMed - indexed for MEDLINE]
4.

Bradykinin B1 antagonists: SAR studies in the 2,3-diaminopyridine series.

Kuduk SD, Chang RK, Ng C, Murphy KL, Ransom RW, Tang C, Prueksaritanont T, Freidinger RM, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2005 Sep 1;15(17):3925-9.

PMID:
15993596
[PubMed - indexed for MEDLINE]
5.

Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.

Su DS, Lim JL, Markowitz MK, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Tang C, Prueksaritanont T, Freidinger RM, Bock MG.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):3006-9. Epub 2007 Mar 21.

PMID:
17428657
[PubMed - indexed for MEDLINE]
6.

Potent nonpeptide antagonists of the bradykinin B1 receptor: structure-activity relationship studies with novel diaminochroman carboxamides.

Biswas K, Li A, Chen JJ, D'Amico DC, Fotsch C, Han N, Human J, Liu Q, Norman MH, Riahi B, Yuan C, Suzuki H, Mareska DA, Zhan J, Clarke DE, Toro A, Groneberg RD, Burgess LE, Lester-Zeiner D, Biddlecome G, Manning BH, Arik L, Dong H, Huang M, Kamassah A, Loeloff R, Sun H, Hsieh FY, Kumar G, Ng GY, Hungate RW, Askew BC, Johnson E.

J Med Chem. 2007 May 3;50(9):2200-12. Epub 2007 Apr 5.

PMID:
17408249
[PubMed - indexed for MEDLINE]
7.

Bradykinin B1 antagonists: biphenyl SAR studies in the cyclopropanecarboxamide series.

Kuduk SD, DiPardo RM, Chang RK, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2007 Jul 1;17(13):3608-12. Epub 2007 Apr 24.

PMID:
17482459
[PubMed - indexed for MEDLINE]
8.

2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists.

Su DS, Lim JL, Tinney E, Wan BL, Murphy KL, Reiss DR, Harrell CM, O'Malley SS, Ransom RW, Chang RS, Pettibone DJ, Yu J, Tang C, Prueksaritanont T, Freidinger RM, Bock MG, Anthony NJ.

J Med Chem. 2008 Jul 10;51(13):3946-52. doi: 10.1021/jm800199h. Epub 2008 Jun 14.

PMID:
18553956
[PubMed - indexed for MEDLINE]
9.

Bradykinin B1 receptor antagonists: an alpha-hydroxy amide with an improved metabolism profile.

Kuduk SD, Chang RK, Dipardo RM, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5107-10. doi: 10.1016/j.bmcl.2008.07.126. Epub 2008 Aug 5.

PMID:
18722115
[PubMed - indexed for MEDLINE]
10.

1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.

Guo Q, Chandrasekhar J, Ihle D, Wustrow DJ, Chenard BL, Krause JE, Hutchison A, Alderman D, Cheng C, Cortright D, Broom D, Kershaw MT, Simmermacher-Mayer J, Peng Y, Hodgetts KJ.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5027-31. doi: 10.1016/j.bmcl.2008.08.014. Epub 2008 Aug 9.

PMID:
18752949
[PubMed - indexed for MEDLINE]
11.

Discovery of dihydroquinoxalinone acetamides containing bicyclic amines as potent Bradykinin B1 receptor antagonists.

Chen JJ, Qian W, Biswas K, Viswanadhan VN, Askew BC, Hitchcock S, Hungate RW, Arik L, Johnson E.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4477-81. doi: 10.1016/j.bmcl.2008.07.055. Epub 2008 Jul 17.

PMID:
18674903
[PubMed - indexed for MEDLINE]
12.

Dual antagonists of the bradykinin B1 and B2 receptors based on a postulated common pharmacophore from existing non-peptide antagonists.

Morissette G, Bouthillier J, Marceau F.

Biol Chem. 2006 Feb;387(2):189-94.

PMID:
16497151
[PubMed - indexed for MEDLINE]
13.

Targeting the bradykinin B1 receptor to reduce pain.

Chen JJ, Johnson EJ.

Expert Opin Ther Targets. 2007 Jan;11(1):21-35. Review.

PMID:
17150032
[PubMed - indexed for MEDLINE]
14.

Preparation and optimization of a series of 3-carboxamido-5-phenacylaminopyrazole bradykinin B1 receptor antagonists.

Dressen D, Garofalo AW, Hawkinson J, Hom D, Jagodzinski J, Marugg JL, Neitzel ML, Pleiss MA, Szoke B, Tung JS, Wone DW, Wu J, Zhang H.

J Med Chem. 2007 Oct 18;50(21):5161-7. Epub 2007 Sep 19.

PMID:
17880055
[PubMed - indexed for MEDLINE]
15.

Chromenones as potent bradykinin B1 antagonists.

Bryan MC, Biswas K, Peterkin TA, Rzasa RM, Arik L, Lehto SG, Sun H, Hsieh FY, Xu C, Fremeau RT, Allen JR.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):619-22. doi: 10.1016/j.bmcl.2011.10.068. Epub 2011 Oct 28.

PMID:
22088753
[PubMed - indexed for MEDLINE]
16.

A new class of bradykinin B1 receptor antagonists with high oral bioavailability and minimal PXR activity.

Feng DM, DiPardo RM, Wai JM, Chang RK, Di Marco CN, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG, Kuduk SD.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):682-7.

PMID:
18240388
[PubMed - indexed for MEDLINE]
17.

Bradykinin B1 receptor antagonists: a patent update 2009 - 2012.

Bozó É, Éles J, Keserű GM.

Expert Opin Ther Pat. 2012 Dec;22(12):1443-52. doi: 10.1517/13543776.2012.730521. Epub 2012 Oct 3. Review.

PMID:
23033970
[PubMed - indexed for MEDLINE]
18.

5-Piperazinyl pyridine carboxamide bradykinin B1 antagonists.

Kuduk SD, Di Marco CN, Chang RK, Wood MR, Kim JJ, Schirripa KM, Murphy KL, Ransom RW, Tang C, Torrent M, Ha S, Prueksaritanont T, Pettibone DJ, Bock MG.

Bioorg Med Chem Lett. 2006 May 15;16(10):2791-5. Epub 2006 Mar 10.

PMID:
16529929
[PubMed - indexed for MEDLINE]
19.

Aspartic acid scaffold in bradykinin B1 antagonists.

Huszár J, Timár Z, Bogár F, Penke B, Kiss R, Szalai KK, Schmidt E, Papp A, Keseru G.

J Pept Sci. 2009 Jun;15(6):423-34. doi: 10.1002/psc.1134.

PMID:
19378355
[PubMed - indexed for MEDLINE]
20.

Indazole derivatives as novel bradykinin B1 receptor antagonists.

Bodmer-Narkevitch V, Anthony NJ, Cofre V, Jolly SM, Murphy KL, Ransom RW, Reiss DR, Tang C, Prueksaritanont T, Pettibone DJ, Bock MG, Kuduk SD.

Bioorg Med Chem Lett. 2010 Dec 1;20(23):7011-4. doi: 10.1016/j.bmcl.2010.09.121. Epub 2010 Sep 29.

PMID:
20971001
[PubMed - indexed for MEDLINE]

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