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Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1.

Viriyakosol S, Fierer J, Brown GD, Kirkland TN.

Infect Immun. 2005 Mar;73(3):1553-60.


Susceptibility to Coccidioides species in C57BL/6 mice is associated with expression of a truncated splice variant of Dectin-1 (Clec7a).

del Pilar Jiménez-A M, Viriyakosol S, Walls L, Datta SK, Kirkland T, Heinsbroek SE, Brown G, Fierer J.

Genes Immun. 2008 Jun;9(4):338-48. doi: 10.1038/gene.2008.23. Epub 2008 Apr 17.


Dectin-1 is required for resistance to coccidioidomycosis in mice.

Viriyakosol S, Jimenez Mdel P, Gurney MA, Ashbaugh ME, Fierer J.

MBio. 2013 Feb 5;4(1):e00597-12. doi: 10.1128/mBio.00597-12.


Innate immune responses to Rhodococcus equi.

Darrah PA, Monaco MC, Jain S, Hondalus MK, Golenbock DT, Mosser DM.

J Immunol. 2004 Aug 1;173(3):1914-24.


Neither dectin-2 nor the mannose receptor is required for resistance to Coccidioides immitis in mice.

Viriyakosol S, Jimenez Mdel P, Saijo S, Fierer J.

Infect Immun. 2014 Mar;82(3):1147-56. doi: 10.1128/IAI.01355-13. Epub 2013 Dec 30.


Differential induction of the toll-like receptor 4-MyD88-dependent and -independent signaling pathways by endotoxins.

Zughaier SM, Zimmer SM, Datta A, Carlson RW, Stephens DS.

Infect Immun. 2005 May;73(5):2940-50. Erratum in: Infect Immun. 2006 May;74(5):3077.


The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol.

Byrd-Leifer CA, Block EF, Takeda K, Akira S, Ding A.

Eur J Immunol. 2001 Aug;31(8):2448-57.


The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Horng T, Barton GM, Flavell RA, Medzhitov R.

Nature. 2002 Nov 21;420(6913):329-33.


Methods of in vitro macrophage maturation confer variable inflammatory responses in association with altered expression of cell surface dectin-1.

Gersuk GM, Razai LW, Marr KA.

J Immunol Methods. 2008 Jan 1;329(1-2):157-66. Epub 2007 Oct 26.


Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88.

Campos MA, Closel M, Valente EP, Cardoso JE, Akira S, Alvarez-Leite JI, Ropert C, Gazzinelli RT.

J Immunol. 2004 Feb 1;172(3):1711-8.


Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.

Huang LY, Aliberti J, Leifer CA, Segal DM, Sher A, Golenbock DT, Golding B.

J Immunol. 2003 Aug 1;171(3):1441-6.


Distinct pathways of LPS-induced NF-kappa B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP.

Andreakos E, Sacre SM, Smith C, Lundberg A, Kiriakidis S, Stonehouse T, Monaco C, Feldmann M, Foxwell BM.

Blood. 2004 Mar 15;103(6):2229-37. Epub 2003 Nov 20.


Immunomodulation via novel use of TLR4 by the filarial nematode phosphorylcholine-containing secreted product, ES-62.

Goodridge HS, Marshall FA, Else KJ, Houston KM, Egan C, Al-Riyami L, Liew FY, Harnett W, Harnett MM.

J Immunol. 2005 Jan 1;174(1):284-93.


TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages.

Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, Williams BR, Major J, Hamilton TA, Fenton MJ, Vogel SN.

Nat Immunol. 2002 Apr;3(4):392-8. Epub 2002 Mar 18.


Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT.

J Immunol. 2002 Oct 1;169(7):3970-7.

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