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Items: 1 to 20 of 259


Disruption of Mcl-1.Bim complex in granzyme B-mediated mitochondrial apoptosis.

Han J, Goldstein LA, Gastman BR, Rabinovitz A, Rabinowich H.

J Biol Chem. 2005 Apr 22;280(16):16383-92. Epub 2005 Feb 15.


Degradation of Mcl-1 by granzyme B: implications for Bim-mediated mitochondrial apoptotic events.

Han J, Goldstein LA, Gastman BR, Froelich CJ, Yin XM, Rabinowich H.

J Biol Chem. 2004 May 21;279(21):22020-9. Epub 2004 Mar 10.


Interrelated roles for Mcl-1 and BIM in regulation of TRAIL-mediated mitochondrial apoptosis.

Han J, Goldstein LA, Gastman BR, Rabinowich H.

J Biol Chem. 2006 Apr 14;281(15):10153-63. Epub 2006 Feb 13.


Resistance to granzyme B-mediated cytochrome c release in Bak-deficient cells.

Wang GQ, Wieckowski E, Goldstein LA, Gastman BR, Rabinovitz A, Gambotto A, Li S, Fang B, Yin XM, Rabinowich H.

J Exp Med. 2001 Nov 5;194(9):1325-37.


Cleavage of Mcl-1 by caspases impaired its ability to counteract Bim-induced apoptosis.

Herrant M, Jacquel A, Marchetti S, Belhacène N, Colosetti P, Luciano F, Auberger P.

Oncogene. 2004 Oct 14;23(47):7863-73.


Evidence for a protective role of Mcl-1 in proteasome inhibitor-induced apoptosis.

Nencioni A, Hua F, Dillon CP, Yokoo R, Scheiermann C, Cardone MH, Barbieri E, Rocco I, Garuti A, Wesselborg S, Belka C, Brossart P, Patrone F, Ballestrero A.

Blood. 2005 Apr 15;105(8):3255-62. Epub 2004 Dec 21.


Granzyme B-mediated degradation of T-cell receptor zeta chain.

Wieckowski E, Wang GQ, Gastman BR, Goldstein LA, Rabinowich H.

Cancer Res. 2002 Sep 1;62(17):4884-9.


Functional linkage between NOXA and Bim in mitochondrial apoptotic events.

Han J, Goldstein LA, Hou W, Rabinowich H.

J Biol Chem. 2007 Jun 1;282(22):16223-31. Epub 2007 Mar 20.


Granzyme B activates procaspase-3 which signals a mitochondrial amplification loop for maximal apoptosis.

Metkar SS, Wang B, Ebbs ML, Kim JH, Lee YJ, Raja SM, Froelich CJ.

J Cell Biol. 2003 Mar 17;160(6):875-85. Epub 2003 Mar 10.


TGFbeta-mediated apoptosis of Burkitt's lymphoma BL41 cells is associated with the relocation of mitochondrial BimEL.

Clybouw C, Mchichi BE, Hadji A, Portier A, Auffredou MT, Arnoult D, Leca G, Vazquez A.

Oncogene. 2008 May 29;27(24):3446-56. doi: 10.1038/sj.onc.1211009. Epub 2008 Jan 14.


BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells.

Schneiders UM, Schyschka L, Rudy A, Vollmar AM.

Mol Cancer Ther. 2009 Oct;8(10):2914-25. doi: 10.1158/1535-7163.MCT-08-1179. Epub 2009 Oct 6.


Noxa up-regulation and Mcl-1 cleavage are associated to apoptosis induction by bortezomib in multiple myeloma.

Gomez-Bougie P, Wuillème-Toumi S, Ménoret E, Trichet V, Robillard N, Philippe M, Bataille R, Amiot M.

Cancer Res. 2007 Jun 1;67(11):5418-24.


Translocation of Bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis.

Morishima N, Nakanishi K, Tsuchiya K, Shibata T, Seiwa E.

J Biol Chem. 2004 Nov 26;279(48):50375-81. Epub 2004 Sep 27.


Reciprocal protection of Mcl-1 and Bim from ubiquitin-proteasome degradation.

Wuillème-Toumi S, Trichet V, Gomez-Bougie P, Gratas C, Bataille R, Amiot M.

Biochem Biophys Res Commun. 2007 Oct 5;361(4):865-9. Epub 2007 Jul 24.


BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.

Weber A, Paschen SA, Heger K, Wilfling F, Frankenberg T, Bauerschmitt H, Seiffert BM, Kirschnek S, Wagner H, Häcker G.

J Cell Biol. 2007 May 21;177(4):625-36.


Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex.

Gomez-Bougie P, Oliver L, Le Gouill S, Bataille R, Amiot M.

Oncogene. 2005 Dec 1;24(54):8076-9.

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