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Results: 1 to 20 of 151

1.

Substrate-specific activation of sirtuins by resveratrol.

Kaeberlein M, McDonagh T, Heltweg B, Hixon J, Westman EA, Caldwell SD, Napper A, Curtis R, DiStefano PS, Fields S, Bedalov A, Kennedy BK.

J Biol Chem. 2005 Apr 29;280(17):17038-45. Epub 2005 Jan 31.

PMID:
15684413
[PubMed - indexed for MEDLINE]
Free Article
2.

Mechanism of human SIRT1 activation by resveratrol.

Borra MT, Smith BC, Denu JM.

J Biol Chem. 2005 Apr 29;280(17):17187-95. Epub 2005 Mar 4.

PMID:
15749705
[PubMed - indexed for MEDLINE]
Free Article
3.

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.

Nature. 2003 Sep 11;425(6954):191-6. Epub 2003 Aug 24.

PMID:
12939617
[PubMed - indexed for MEDLINE]
4.

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.

J Biol Chem. 2002 Nov 22;277(47):45099-107. Epub 2002 Sep 23.

PMID:
12297502
[PubMed - indexed for MEDLINE]
Free Article
5.

Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition.

Sauve AA, Moir RD, Schramm VL, Willis IM.

Mol Cell. 2005 Feb 18;17(4):595-601.

PMID:
15721262
[PubMed - indexed for MEDLINE]
6.

Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.

Borra MT, Langer MR, Slama JT, Denu JM.

Biochemistry. 2004 Aug 3;43(30):9877-87.

PMID:
15274642
[PubMed - indexed for MEDLINE]
7.

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase.

Imai S, Armstrong CM, Kaeberlein M, Guarente L.

Nature. 2000 Feb 17;403(6771):795-800.

PMID:
10693811
[PubMed - indexed for MEDLINE]
8.

Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p.

Smith JS, Brachmann CB, Pillus L, Boeke JD.

Genetics. 1998 Jul;149(3):1205-19.

PMID:
9649515
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

Kim S, Benguria A, Lai CY, Jazwinski SM.

Mol Biol Cell. 1999 Oct;10(10):3125-36.

PMID:
10512855
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

The Sir2 family of protein deacetylases.

Blander G, Guarente L.

Annu Rev Biochem. 2004;73:417-35. Review.

PMID:
15189148
[PubMed - indexed for MEDLINE]
11.

The flavoring agent dihydrocoumarin reverses epigenetic silencing and inhibits sirtuin deacetylases.

Olaharski AJ, Rine J, Marshall BL, Babiarz J, Zhang L, Verdin E, Smith MT.

PLoS Genet. 2005 Dec;1(6):e77. Epub 2005 Dec 16.

PMID:
16362078
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

Mai A, Massa S, Lavu S, Pezzi R, Simeoni S, Ragno R, Mariotti FR, Chiani F, Camilloni G, Sinclair DA.

J Med Chem. 2005 Dec 1;48(24):7789-95.

PMID:
16302818
[PubMed - indexed for MEDLINE]
13.

Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity.

Gallo CM, Smith DL Jr, Smith JS.

Mol Cell Biol. 2004 Feb;24(3):1301-12.

PMID:
14729974
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

HST2 mediates SIR2-independent life-span extension by calorie restriction.

Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA.

Science. 2005 Sep 16;309(5742):1861-4. Epub 2005 Jul 28.

PMID:
16051752
[PubMed - indexed for MEDLINE]
Free Article
15.

Human Sir2 and the 'silencing' of p53 activity.

Smith J.

Trends Cell Biol. 2002 Sep;12(9):404-6.

PMID:
12220851
[PubMed - indexed for MEDLINE]
16.

Sir2-independent life span extension by calorie restriction in yeast.

Kaeberlein M, Kirkland KT, Fields S, Kennedy BK.

PLoS Biol. 2004 Sep;2(9):E296. Epub 2004 Aug 24.

PMID:
15328540
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

A molecular mechanism for direct sirtuin activation by resveratrol.

Gertz M, Nguyen GT, Fischer F, Suenkel B, Schlicker C, Fränzel B, Tomaschewski J, Aladini F, Becker C, Wolters D, Steegborn C.

PLoS One. 2012;7(11):e49761. doi: 10.1371/journal.pone.0049761. Epub 2012 Nov 21.

PMID:
23185430
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.

Tsuchiya M, Dang N, Kerr EO, Hu D, Steffen KK, Oakes JA, Kennedy BK, Kaeberlein M.

Aging Cell. 2006 Dec;5(6):505-14.

PMID:
17129213
[PubMed - indexed for MEDLINE]
19.

Sound silencing: the Sir2 protein and cellular senescence.

Defossez PA, Lin SJ, McNabb DS.

Bioessays. 2001 Apr;23(4):327-32. Review.

PMID:
11268038
[PubMed - indexed for MEDLINE]
20.

Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.

Hirao M, Posakony J, Nelson M, Hruby H, Jung M, Simon JA, Bedalov A.

J Biol Chem. 2003 Dec 26;278(52):52773-82. Epub 2003 Oct 8.

PMID:
14534292
[PubMed - indexed for MEDLINE]
Free Article

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