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Human monoclonal antibodies that neutralize anthrax toxin by inhibiting heptamer assembly.

Wang F, Ruther P, Jiang I, Sawada-Hirai R, Sun SM, Nedellec R, Morrow PR, Kang AS.

Hum Antibodies. 2004;13(4):105-10.


Human anti-anthrax protective antigen neutralizing monoclonal antibodies derived from donors vaccinated with anthrax vaccine adsorbed.

Sawada-Hirai R, Jiang I, Wang F, Sun SM, Nedellec R, Ruther P, Alvarez A, Millis D, Morrow PR, Kang AS.

J Immune Based Ther Vaccines. 2004 May 12;2(1):5.


Neutralizing monoclonal antibodies directed against defined linear epitopes on domain 4 of anthrax protective antigen.

Kelly-Cirino CD, Mantis NJ.

Infect Immun. 2009 Nov;77(11):4859-67. doi: 10.1128/IAI.00117-09. Epub 2009 Aug 24.


[Monoclonal antibodies to B.anthracis protective antigen are capable to neutralize and to enhance the anthrax lethal toxin action in vitro].

Belova EV, Dubileń≠ SA, Kravchenko TB, Kolesnikov AV, Zakharova MIu, Shemiakin IG.

Mol Gen Mikrobiol Virusol. 2004;(3):21-6. Russian.


Mechanism of lethal toxin neutralization by a human monoclonal antibody specific for the PA(20) region of Bacillus anthracis protective antigen.

Reason D, Liberato J, Sun J, Camacho J, Zhou J.

Toxins (Basel). 2011 Aug;3(8):979-90. doi: 10.3390/toxins3080979. Epub 2011 Aug 9.


Human monoclonal anti-protective antigen antibody completely protects rabbits and is synergistic with ciprofloxacin in protecting mice and guinea pigs against inhalation anthrax.

Peterson JW, Comer JE, Noffsinger DM, Wenglikowski A, Walberg KG, Chatuev BM, Chopra AK, Stanberry LR, Kang AS, Scholz WW, Sircar J.

Infect Immun. 2006 Feb;74(2):1016-24.


Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies.

Nguyen ML, Crowe SR, Kurella S, Teryzan S, Cao B, Ballard JD, James JA, Farris AD.

Infect Immun. 2009 Jan;77(1):162-9. doi: 10.1128/IAI.00788-08. Epub 2008 Nov 3.


Human monoclonal antibody AVP-21D9 to protective antigen reduces dissemination of the Bacillus anthracis Ames strain from the lungs in a rabbit model.

Peterson JW, Comer JE, Baze WB, Noffsinger DM, Wenglikowski A, Walberg KG, Hardcastle J, Pawlik J, Bush K, Taormina J, Moen S, Thomas J, Chatuev BM, Sower L, Chopra AK, Stanberry LR, Sawada R, Scholz WW, Sircar J.

Infect Immun. 2007 Jul;75(7):3414-24. Epub 2007 Apr 23.


Frequency and domain specificity of toxin-neutralizing paratopes in the human antibody response to anthrax vaccine adsorbed.

Reason D, Liberato J, Sun J, Keitel W, Zhou J.

Infect Immun. 2009 May;77(5):2030-5. doi: 10.1128/IAI.01254-08. Epub 2009 Feb 17.


Novel chimpanzee/human monoclonal antibodies that neutralize anthrax lethal factor, and evidence for possible synergy with anti-protective antigen antibody.

Chen Z, Moayeri M, Crown D, Emerson S, Gorshkova I, Schuck P, Leppla SH, Purcell RH.

Infect Immun. 2009 Sep;77(9):3902-8. doi: 10.1128/IAI.00200-09. Epub 2009 Jun 15.


Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen.

Gubbins MJ, Berry JD, Corbett CR, Mogridge J, Yuan XY, Schmidt L, Nicolas B, Kabani A, Tsang RS.

FEMS Immunol Med Microbiol. 2006 Aug;47(3):436-43.


[Toxin-neutralizing monoclonal antibodies to the different domains of anthrax protective antigen].

Xu JJ, Zhang J, Liu SL, Lv TJ, Chen W, Li GL, Ge M, Guo Q.

Wei Sheng Wu Xue Bao. 2005 Dec;45(6):947-51. Chinese.


A novel mechanism for antibody-based anthrax toxin neutralization: inhibition of prepore-to-pore conversion.

Mechaly A, Levy H, Epstein E, Rosenfeld R, Marcus H, Ben-Arie E, Shafferman A, Ordentlich A, Mazor O.

J Biol Chem. 2012 Sep 21;287(39):32665-73. Epub 2012 Aug 6.


Vaccination of rhesus macaques with the anthrax vaccine adsorbed vaccine produces a serum antibody response that effectively neutralizes receptor-bound protective antigen in vitro.

Clement KH, Rudge TL Jr, Mayfield HJ, Carlton LA, Hester A, Niemuth NA, Sabourin CL, Brys AM, Quinn CP.

Clin Vaccine Immunol. 2010 Nov;17(11):1753-62. doi: 10.1128/CVI.00174-10. Epub 2010 Aug 25.


The major neutralizing antibody responses to recombinant anthrax lethal and edema factors are directed to non-cross-reactive epitopes.

Nguyen ML, Terzyan S, Ballard JD, James JA, Farris AD.

Infect Immun. 2009 Nov;77(11):4714-23. doi: 10.1128/IAI.00749-09. Epub 2009 Aug 31.


Analysis of the Fc gamma receptor-dependent component of neutralization measured by anthrax toxin neutralization assays.

Verma A, Ngundi MM, Meade BD, De Pascalis R, Elkins KL, Burns DL.

Clin Vaccine Immunol. 2009 Oct;16(10):1405-12. doi: 10.1128/CVI.00194-09. Epub 2009 Aug 5.


Combinations of monoclonal antibodies to anthrax toxin manifest new properties in neutralization assays.

Pohl MA, Rivera J, Nakouzi A, Chow SK, Casadevall A.

Infect Immun. 2013 Jun;81(6):1880-8. doi: 10.1128/IAI.01328-12. Epub 2013 Mar 18.


Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax.

Albrecht MT, Li H, Williamson ED, LeButt CS, Flick-Smith HC, Quinn CP, Westra H, Galloway D, Mateczun A, Goldman S, Groen H, Baillie LW.

Infect Immun. 2007 Nov;75(11):5425-33. Epub 2007 Jul 23.


Anthrax toxin-neutralizing antibody reconfigures the protective antigen heptamer into a supercomplex.

Radjainia M, Hyun JK, Leysath CE, Leppla SH, Mitra AK.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14070-4. doi: 10.1073/pnas.1006473107. Epub 2010 Jul 26.

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