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Results: 1 to 20 of 265

1.

An RNAi strategy for treatment of amyotrophic lateral sclerosis caused by mutant Cu,Zn superoxide dismutase.

Xia XG, Zhou H, Zhou S, Yu Y, Wu R, Xu Z.

J Neurochem. 2005 Jan;92(2):362-7. Erratum in: J Neurochem. 2005 Mar;92(6):1554.

PMID:
15663483
[PubMed - indexed for MEDLINE]
2.

Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis.

Ding H, Schwarz DS, Keene A, Affar el B, Fenton L, Xia X, Shi Y, Zamore PD, Xu Z.

Aging Cell. 2003 Aug;2(4):209-17.

PMID:
12934714
[PubMed - indexed for MEDLINE]
3.

Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo.

Xia X, Zhou H, Huang Y, Xu Z.

Neurobiol Dis. 2006 Sep;23(3):578-86. Epub 2006 Jul 20.

PMID:
16857362
[PubMed - indexed for MEDLINE]
4.

Inhibition of chaperone activity is a shared property of several Cu,Zn-superoxide dismutase mutants that cause amyotrophic lateral sclerosis.

Tummala H, Jung C, Tiwari A, Higgins CM, Hayward LJ, Xu Z.

J Biol Chem. 2005 May 6;280(18):17725-31. Epub 2005 Mar 7.

PMID:
15753080
[PubMed - indexed for MEDLINE]
Free Article
5.

RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells.

Maxwell MM, Pasinelli P, Kazantsev AG, Brown RH Jr.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3178-83. Epub 2004 Feb 23.

PMID:
14981234
[PubMed - indexed for MEDLINE]
Free PMC Article
6.
7.

Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation.

Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C, Clement AM.

Hum Mol Genet. 2008 May 15;17(10):1373-85. doi: 10.1093/hmg/ddn025. Epub 2008 Jan 22.

PMID:
18211954
[PubMed - indexed for MEDLINE]
Free Article
8.

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.

Turner BJ, Atkin JD, Farg MA, Zang DW, Rembach A, Lopes EC, Patch JD, Hill AF, Cheema SS.

J Neurosci. 2005 Jan 5;25(1):108-17.

PMID:
15634772
[PubMed - indexed for MEDLINE]
Free Article
9.

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model.

Ralph GS, Radcliffe PA, Day DM, Carthy JM, Leroux MA, Lee DC, Wong LF, Bilsland LG, Greensmith L, Kingsman SM, Mitrophanous KA, Mazarakis ND, Azzouz M.

Nat Med. 2005 Apr;11(4):429-33. Epub 2005 Mar 13.

PMID:
15768029
[PubMed - indexed for MEDLINE]
Free Article
10.

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.

Jaarsma D, Teuling E, Haasdijk ED, De Zeeuw CI, Hoogenraad CC.

J Neurosci. 2008 Feb 27;28(9):2075-88. doi: 10.1523/JNEUROSCI.5258-07.2008.

PMID:
18305242
[PubMed - indexed for MEDLINE]
Free Article
11.

Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress.

Cookson MR, Menzies FM, Manning P, Eggett CJ, Figlewicz DA, McNeil CJ, Shaw PJ.

Amyotroph Lateral Scler Other Motor Neuron Disord. 2002 Jun;3(2):75-85.

PMID:
12215229
[PubMed - indexed for MEDLINE]
12.

Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex.

Zhang F, Ström AL, Fukada K, Lee S, Hayward LJ, Zhu H.

J Biol Chem. 2007 Jun 1;282(22):16691-9. Epub 2007 Apr 2.

PMID:
17403682
[PubMed - indexed for MEDLINE]
Free Article
13.

Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis.

Urushitani M, Kurisu J, Tsukita K, Takahashi R.

J Neurochem. 2002 Dec;83(5):1030-42.

PMID:
12437574
[PubMed - indexed for MEDLINE]
14.

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS.

Turner BJ, Talbot K.

Prog Neurobiol. 2008 May;85(1):94-134. doi: 10.1016/j.pneurobio.2008.01.001. Epub 2008 Jan 16. Review.

PMID:
18282652
[PubMed - indexed for MEDLINE]
15.

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions.

Kunst CB, Mezey E, Brownstein MJ, Patterson D.

Nat Genet. 1997 Jan;15(1):91-4.

PMID:
8988176
[PubMed - indexed for MEDLINE]
16.

Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS.

Raoul C, Abbas-Terki T, Bensadoun JC, Guillot S, Haase G, Szulc J, Henderson CE, Aebischer P.

Nat Med. 2005 Apr;11(4):423-8. Epub 2005 Mar 13.

PMID:
15768028
[PubMed - indexed for MEDLINE]
Free Article
17.

Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells.

Oh YK, Shin KS, Yuan J, Kang SJ.

J Neurochem. 2008 Feb;104(4):993-1005. doi: 10.1111/j.1471-4159.2007.05053.x.

PMID:
18233996
[PubMed - indexed for MEDLINE]
18.

Familial amyotrophic lateral sclerosis-linked mutant SOD1 aberrantly interacts with tubulin.

Kabuta T, Kinugawa A, Tsuchiya Y, Kabuta C, Setsuie R, Tateno M, Araki T, Wada K.

Biochem Biophys Res Commun. 2009 Sep 11;387(1):121-6. doi: 10.1016/j.bbrc.2009.06.138. Epub 2009 Jul 1.

PMID:
19576169
[PubMed - indexed for MEDLINE]
19.

Instability of mutant Cu/Zn superoxide dismutase (Ala4Thr) associated with familial amyotrophic lateral sclerosis.

Nakano R, Inuzuka T, Kikugawa K, Takahashi H, Sakimura K, Fujii J, Taniguchi N, Tsuji S.

Neurosci Lett. 1996 Jun 21;211(2):129-31.

PMID:
8830861
[PubMed - indexed for MEDLINE]
20.

In vivo application of an RNAi strategy for the selective suppression of a mutant allele.

Kubodera T, Yamada H, Anzai M, Ohira S, Yokota S, Hirai Y, Mochizuki H, Shimada T, Mitani T, Mizusawa H, Yokota T.

Hum Gene Ther. 2011 Jan;22(1):27-34. doi: 10.1089/hum.2010.054.

PMID:
20649474
[PubMed - indexed for MEDLINE]

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