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Results: 1 to 20 of 239

1.

Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau.

Tsujio I, Zaidi T, Xu J, Kotula L, Grundke-Iqbal I, Iqbal K.

FEBS Lett. 2005 Jan 17;579(2):363-72.

PMID:
15642345
[PubMed - indexed for MEDLINE]
Free Article
2.

Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.

Chohan MO, Khatoon S, Iqbal IG, Iqbal K.

FEBS Lett. 2006 Jul 10;580(16):3973-9. Epub 2006 Jun 19.

PMID:
16806196
[PubMed - indexed for MEDLINE]
Free Article
3.

Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.

Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM.

J Biol Chem. 2004 Dec 31;279(53):54983-6. Epub 2004 Nov 3.

PMID:
15525651
[PubMed - indexed for MEDLINE]
Free Article
4.

Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice.

Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J.

J Biol Chem. 2001 Oct 12;276(41):38193-200. Epub 2001 Jul 25.

PMID:
11473109
[PubMed - indexed for MEDLINE]
Free Article
5.

Inhibitors of protein phosphatase-2A: topography and subcellular localization.

Tanimukai H, Grundke-Iqbal I, Iqbal K.

Brain Res Mol Brain Res. 2004 Jul 26;126(2):146-56.

PMID:
15249138
[PubMed - indexed for MEDLINE]
6.

Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K.

J Biol Chem. 2000 Feb 25;275(8):5535-44.

PMID:
10681533
[PubMed - indexed for MEDLINE]
Free Article
7.

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ.

Neurobiol Dis. 2008 Sep;31(3):386-94. doi: 10.1016/j.nbd.2008.05.013. Epub 2008 Jul 23.

PMID:
18586097
[PubMed - indexed for MEDLINE]
8.

Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.

PMID:
12963337
[PubMed - indexed for MEDLINE]
9.

FTDP-17 missense mutations site-specifically inhibit as well as promote dephosphorylation of microtubule-associated protein tau by protein phosphatases of HEK-293 cell extract.

Han D, Paudel HK.

Neurochem Int. 2009 Jan;54(1):14-27. doi: 10.1016/j.neuint.2008.09.014. Epub 2008 Oct 15.

PMID:
18992292
[PubMed - indexed for MEDLINE]
10.

Molecular interactions among protein phosphatase 2A, tau, and microtubules. Implications for the regulation of tau phosphorylation and the development of tauopathies.

Sontag E, Nunbhakdi-Craig V, Lee G, Brandt R, Kamibayashi C, Kuret J, White CL 3rd, Mumby MC, Bloom GS.

J Biol Chem. 1999 Sep 3;274(36):25490-8.

PMID:
10464280
[PubMed - indexed for MEDLINE]
Free Article
11.

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.

Liu F, Grundke-Iqbal I, Iqbal K, Gong CX.

Eur J Neurosci. 2005 Oct;22(8):1942-50.

PMID:
16262633
[PubMed - indexed for MEDLINE]
12.

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

Gong CX, Grundke-Iqbal I, Iqbal K.

Neuroscience. 1994 Aug;61(4):765-72.

PMID:
7838376
[PubMed - indexed for MEDLINE]
13.

Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology.

Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA, Winblad B, Pei JJ.

J Cell Mol Med. 2008 Jan-Feb;12(1):241-57. doi: 10.1111/j.1582-4934.2008.00249.x. Epub 2008 Jan 19.

PMID:
18208556
[PubMed - indexed for MEDLINE]
14.

In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons.

Saito T, Ishiguro K, Uchida T, Miyamoto E, Kishimoto T, Hisanaga S.

FEBS Lett. 1995 Dec 4;376(3):238-42.

PMID:
7498550
[PubMed - indexed for MEDLINE]
Free Article
15.

Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A.

Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC.

Neuron. 1996 Dec;17(6):1201-7.

PMID:
8982166
[PubMed - indexed for MEDLINE]
Free Article
16.

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.

Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong CX.

J Biol Chem. 2005 Jan 21;280(3):1790-6. Epub 2004 Nov 15.

PMID:
15546861
[PubMed - indexed for MEDLINE]
Free Article
17.

Inhibition of protein phosphatase-2B (calcineurin) activity towards Alzheimer abnormally phosphorylated tau by neuroleptics.

Gong CX, Shaikh S, Grundke-Iqbal I, Iqbal K.

Brain Res. 1996 Nov 25;741(1-2):95-102.

PMID:
9001710
[PubMed - indexed for MEDLINE]
18.

Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.

Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K.

FEBS Lett. 2001 Feb 9;490(1-2):15-22.

PMID:
11172803
[PubMed - indexed for MEDLINE]
Free Article
19.

Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5.

Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX.

Neuroscience. 2002;115(3):829-37.

PMID:
12435421
[PubMed - indexed for MEDLINE]
20.

Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease.

Tanimukai H, Grundke-Iqbal I, Iqbal K.

Am J Pathol. 2005 Jun;166(6):1761-71.

PMID:
15920161
[PubMed - indexed for MEDLINE]
Free PMC Article

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