Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 98

1.

Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3).

Kahraman M, Sinishtaj S, Dolan PM, Kensler TW, Peleg S, Saha U, Chuang SS, Bernstein G, Korczak B, Posner GH.

J Med Chem. 2004 Dec 30;47(27):6854-63.

PMID:
15615534
[PubMed - indexed for MEDLINE]
2.

Potent, low-calcemic, selective inhibitors of CYP24 hydroxylase: 24-sulfone analogs of the hormone 1alpha,25-dihydroxyvitamin D3.

Posner GH, Crawford KR, Yang HW, Kahraman M, Jeon HB, Li H, Lee JK, Suh BC, Hatcher MA, Labonte T, Usera A, Dolan PM, Kensler TW, Peleg S, Jones G, Zhang A, Korczak B, Saha U, Chuang SS.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):5-12.

PMID:
15225738
[PubMed - indexed for MEDLINE]
3.

Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biological evaluation.

Posner GH, Lee JK, Wang Q, Peleg S, Burke M, Brem H, Dolan P, Kensler TW.

J Med Chem. 1998 Jul 30;41(16):3008-14.

PMID:
9685240
[PubMed - indexed for MEDLINE]
4.

Selective inhibitors of CYP24: mechanistic tools to explore vitamin D metabolism in human keratinocytes.

Schuster I, Egger H, Astecker N, Herzig G, Schüssler M, Vorisek G.

Steroids. 2001 Mar-May;66(3-5):451-62.

PMID:
11179754
[PubMed - indexed for MEDLINE]
5.

Combination of vitamin D metabolites with selective inhibitors of vitamin D metabolism.

Schuster I, Egger H, Reddy GS, Vorisek G.

Recent Results Cancer Res. 2003;164:169-88. Review.

PMID:
12899522
[PubMed - indexed for MEDLINE]
6.

Selective inhibition of vitamin D hydroxylases in human keratinocytes.

Schuster I, Egger H, Bikle D, Herzig G, Reddy GS, Stuetz A, Stuetz P, Vorisek G.

Steroids. 2001 Mar-May;66(3-5):409-22.

PMID:
11179750
[PubMed - indexed for MEDLINE]
7.

Vitamin D analogues targeting CYP24 in chronic kidney disease.

Posner GH, Helvig C, Cuerrier D, Collop D, Kharebov A, Ryder K, Epps T, Petkovich M.

J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):13-9. doi: 10.1016/j.jsbmb.2010.03.065. Epub 2010 Mar 27.

PMID:
20347976
[PubMed - indexed for MEDLINE]
8.

A 24-phenylsulfone analog of vitamin D inhibits 1alpha,25-dihydroxyvitamin D(3) degradation in vitamin D metabolism-competent cells.

Lechner D, Manhardt T, Bajna E, Posner GH, Cross HS.

J Pharmacol Exp Ther. 2007 Mar;320(3):1119-26. Epub 2006 Dec 20.

PMID:
17182978
[PubMed - indexed for MEDLINE]
Free Article
9.

Inhibitors of vitamin D hydroxylases: structure-activity relationships.

Schuster I, Egger H, Nussbaumer P, Kroemer RT.

J Cell Biochem. 2003 Feb 1;88(2):372-80.

PMID:
12520539
[PubMed - indexed for MEDLINE]
10.

Metabolic studies using recombinant escherichia coli cells producing rat mitochondrial CYP24 CYP24 can convert 1alpha,25-dihydroxyvitamin D3 to calcitroic acid.

Sakaki T, Sawada N, Nonaka Y, Ohyama Y, Inouye K.

Eur J Biochem. 1999 May;262(1):43-8.

PMID:
10231362
[PubMed - indexed for MEDLINE]
Free Article
11.

Low-calcemic, highly antiproliferative, 1-difluoromethyl hybrid analogs of the natural hormone 1alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evaluation.

Peleg S, Petersen KS, Suh BC, Dolan P, Agoston ES, Kensler TW, Posner GH.

J Med Chem. 2006 Dec 14;49(25):7513-7.

PMID:
17149880
[PubMed - indexed for MEDLINE]
12.

Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.

Posner GH, Wang Q, Han G, Lee JK, Crawford K, Zand S, Brem H, Peleg S, Dolan P, Kensler TW.

J Med Chem. 1999 Sep 9;42(18):3425-35.

PMID:
10479276
[PubMed - indexed for MEDLINE]
13.

Role of 24-hydroxylase in vitamin D3 growth response of OVCAR-3 ovarian cancer cells.

Miettinen S, Ahonen MH, Lou YR, Manninen T, Tuohimaa P, Syvälä H, Ylikomi T.

Int J Cancer. 2004 Jan 20;108(3):367-73.

PMID:
14648702
[PubMed - indexed for MEDLINE]
14.

Comparative effects of 1,25-dihydroxyvitamin D3 and EB 1089 on mouse renal and intestinal 25-hydroxyvitamin D3-24-hydroxylase.

Roy S, Martel J, Tenenhouse HS.

J Bone Miner Res. 1995 Dec;10(12):1951-9.

PMID:
8619376
[PubMed - indexed for MEDLINE]
15.

1alpha,25-dihydroxyvitamin D3-24-hydroxylase (CYP24) hydroxylates the carbon at the end of the side chain (C-26) of the C-24-fluorinated analog of 1alpha,25-dihydroxyvitamin D3.

Miyamoto Y, Shinki T, Yamamoto K, Ohyama Y, Iwasaki H, Hosotani R, Kasama T, Takayama H, Yamada S, Suda T.

J Biol Chem. 1997 May 30;272(22):14115-9.

PMID:
9162038
[PubMed - indexed for MEDLINE]
Free Article
16.

Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation.

Posner GH, Crawford K, Siu-Caldera ML, Reddy GS, Sarabia SF, Feldman D, van Etten E, Mathieu C, Gennaro L, Vouros P, Peleg S, Dolan PM, Kensler TW.

J Med Chem. 2000 Sep 21;43(19):3581-6.

PMID:
11000014
[PubMed - indexed for MEDLINE]
17.

Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells.

Farhan H, Wähälä K, Cross HS.

J Steroid Biochem Mol Biol. 2003 Mar;84(4):423-9.

PMID:
12732287
[PubMed - indexed for MEDLINE]
18.

Metabolism of 20-epimer of 1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats.

Kusudo T, Sakaki T, Abe D, Fujishima T, Kittaka A, Takayama H, Ohta M, Inouye K.

Biochem Biophys Res Commun. 2003 Oct 3;309(4):885-92.

PMID:
13679056
[PubMed - indexed for MEDLINE]
19.

Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review).

Wikvall K.

Int J Mol Med. 2001 Feb;7(2):201-9. Review.

PMID:
11172626
[PubMed - indexed for MEDLINE]
20.

Metabolism of 26,26,26,27,27,27-F6-1alpha,25-dihydroxyvitamin D3 by CYP24: species-based difference between humans and rats.

Sakaki T, Sawada N, Abe D, Komai K, Shiozawa S, Nonaka Y, Nakagawa K, Okano T, Ohta M, Inouye K.

Biochem Pharmacol. 2003 Jun 15;65(12):1957-65.

PMID:
12787875
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk