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Items: 1 to 20 of 526

1.

Metabolism of vitamin D3 by cytochromes P450.

Sakaki T, Kagawa N, Yamamoto K, Inouye K.

Front Biosci. 2005 Jan 1;10:119-34. Print 2005 Jan 1. Review.

PMID:
15574355
2.

[Recent studies on vitamin D metabolizing enzymes].

Sakaki T.

Clin Calcium. 2006 Jul;16(7):1129-35. Review. Japanese.

PMID:
16816472
4.
5.

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS.

J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789.

PMID:
24535953
6.

Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1.

Abe D, Sakaki T, Kusudo T, Kittaka A, Saito N, Suhara Y, Fujishima T, Takayama H, Hamamoto H, Kamakura M, Ohta M, Inouye K.

Drug Metab Dispos. 2005 Jun;33(6):778-84. Epub 2005 Mar 11.

7.

Metabolic stability of 3-epi-1α,25-dihydroxyvitamin D3 over 1 α 25-dihydroxyvitamin D3: metabolism and molecular docking studies using rat CYP24A1.

Rhieu SY, Annalora AJ, Wang G, Flarakos CC, Gathungu RM, Vouros P, Sigüeiro R, Mouriño A, Schuster I, Palmore GT, Reddy GS.

J Cell Biochem. 2013 Oct;114(10):2293-305. doi: 10.1002/jcb.24576.

PMID:
23606409
8.

Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24.

Sakaki T, Sawada N, Komai K, Shiozawa S, Yamada S, Yamamoto K, Ohyama Y, Inouye K.

Eur J Biochem. 2000 Oct;267(20):6158-65.

9.

Altered pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D3 in the blood and tissues of the 25-hydroxyvitamin D-24-hydroxylase (Cyp24a1) null mouse.

Masuda S, Byford V, Arabian A, Sakai Y, Demay MB, St-Arnaud R, Jones G.

Endocrinology. 2005 Feb;146(2):825-34. Epub 2004 Oct 21.

PMID:
15498883
10.

C-25 hydroxylation of 1alpha,24(R)-dihydroxyvitamin D3 is catalyzed by 25-hydroxyvitamin D3-24-hydroxylase (CYP24A1): metabolism studies with human keratinocytes and rat recombinant CYP24A1.

Astecker N, Bobrovnikova EA, Omdahl JL, Gennaro L, Vouros P, Schuster I, Uskokovic MR, Ishizuka S, Wang G, Reddy GS.

Arch Biochem Biophys. 2004 Nov 15;431(2):261-70.

PMID:
15488475
11.

Monocyte-derived cells express CYP27A1 and convert vitamin D3 into its active metabolite.

Gottfried E, Rehli M, Hahn J, Holler E, Andreesen R, Kreutz M.

Biochem Biophys Res Commun. 2006 Oct 13;349(1):209-13. Epub 2006 Aug 15.

PMID:
16930540
12.

Bioengineering anabolic vitamin D-25-hydroxylase activity into the human vitamin D catabolic enzyme, cytochrome P450 CYP24A1, by a V391L mutation.

Kaufmann M, Prosser DE, Jones G.

J Biol Chem. 2011 Aug 19;286(33):28729-37. doi: 10.1074/jbc.M111.236679. Epub 2011 Jun 22.

13.

Calcitriol regulates the expression of the genes encoding the three key vitamin D3 hydroxylases and the drug-metabolizing enzyme CYP3A4 in the human fetal intestine.

Theodoropoulos C, Demers C, Delvin E, Ménard D, Gascon-Barré M.

Clin Endocrinol (Oxf). 2003 Apr;58(4):489-99.

PMID:
12641633
14.

Homology modeling of human 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1) based on the crystal structure of rabbit CYP2C5.

Yamamoto K, Masuno H, Sawada N, Sakaki T, Inouye K, Ishiguro M, Yamada S.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):167-71.

PMID:
15225767
15.

Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1.

Tang EK, Chen J, Janjetovic Z, Tieu EW, Slominski AT, Li W, Tuckey RC.

Drug Metab Dispos. 2013 May;41(5):1112-24. doi: 10.1124/dmd.113.050955. Epub 2013 Mar 1.

16.

24R,25-dihydroxyvitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells.

Curtis KM, Aenlle KK, Roos BA, Howard GA.

Mol Endocrinol. 2014 May;28(5):644-58. doi: 10.1210/me.2013-1241. Epub 2014 Mar 5.

17.

C-3 epimerization of vitamin D3 metabolites and further metabolism of C-3 epimers: 25-hydroxyvitamin D3 is metabolized to 3-epi-25-hydroxyvitamin D3 and subsequently metabolized through C-1alpha or C-24 hydroxylation.

Kamao M, Tatematsu S, Hatakeyama S, Sakaki T, Sawada N, Inouye K, Ozono K, Kubodera N, Reddy GS, Okano T.

J Biol Chem. 2004 Apr 16;279(16):15897-907. Epub 2004 Feb 2.

18.
19.

Metabolism of vitamin D(3) by human CYP27A1.

Sawada N, Sakaki T, Ohta M, Inouye K.

Biochem Biophys Res Commun. 2000 Jul 14;273(3):977-84.

PMID:
10891358
20.

Cell specificity and properties of the C-3 epimerization of Vitamin D3 metabolites.

Kamao M, Tatematsu S, Sawada N, Sakaki T, Hatakeyama S, Kubodera N, Okano T.

J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):39-42.

PMID:
15225744
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