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Items: 1 to 20 of 126

1.

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct.

Tarassishin L, Yin YI, Bassit B, Li YM.

Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17050-5. Epub 2004 Nov 24.

2.

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.

Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C.

J Cell Biol. 2002 Aug 5;158(3):551-61. Epub 2002 Jul 29.

3.

Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression.

Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT.

J Biol Chem. 2003 Nov 28;278(48):47370-5. Epub 2003 Sep 5.

4.

Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins.

Steiner H, Winkler E, Shearman MS, Prywes R, Haass C.

Neurobiol Dis. 2001 Aug;8(4):717-22.

PMID:
11493036
5.

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT.

J Neurochem. 2000 Aug;75(2):583-93.

6.

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling.

Roncarati R, Sestan N, Scheinfeld MH, Berechid BE, Lopez PA, Meucci O, McGlade JC, Rakic P, D'Adamio L.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):7102-7.

7.

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage.

Chyung JH, Raper DM, Selkoe DJ.

J Biol Chem. 2005 Feb 11;280(6):4383-92. Epub 2004 Nov 29.

8.

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ.

Nature. 2000 Jun 8;405(6787):689-94.

PMID:
10864326
9.

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages.

Lewis HD, Pérez Revuelta BI, Nadin A, Neduvelil JG, Harrison T, Pollack SJ, Shearman MS.

Biochemistry. 2003 Jun 24;42(24):7580-6.

PMID:
12809514
10.

The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein.

Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W.

J Cell Biol. 2001 Aug 20;154(4):731-40. Epub 2001 Aug 13.

12.

A sensitive and quantitative assay for measuring cleavage of presenilin substrates.

Karlström H, Bergman A, Lendahl U, Näslund J, Lundkvist J.

J Biol Chem. 2002 Mar 1;277(9):6763-6. Epub 2001 Dec 13.

13.

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.

Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B.

J Neurochem. 2006 Feb;96(3):732-42. Epub 2006 Jan 9.

14.

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R.

Nature. 1999 Apr 8;398(6727):518-22.

PMID:
10206645
15.

Gamma-secretase: substrates and inhibitors.

Rochette MJ, Murphy MP.

Mol Neurobiol. 2002 Aug;26(1):81-95.

PMID:
12392058
16.

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch.

Chen F, Gu Y, Hasegawa H, Ruan X, Arawaka S, Fraser P, Westaway D, Mount H, St George-Hyslop P.

J Biol Chem. 2002 Sep 27;277(39):36521-6. Epub 2002 Jul 15.

17.

The role of presenilin-1 in the gamma-secretase cleavage of the amyloid precursor protein of Alzheimer's disease.

Octave JN, Essalmani R, Tasiaux B, Menager J, Czech C, Mercken L.

J Biol Chem. 2000 Jan 21;275(3):1525-8.

18.

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function.

Das I, Craig C, Funahashi Y, Jung KM, Kim TW, Byers R, Weng AP, Kutok JL, Aster JC, Kitajewski J.

J Biol Chem. 2004 Jul 16;279(29):30771-80. Epub 2004 May 3.

19.

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS.

Nat Cell Biol. 2000 Jul;2(7):428-34.

PMID:
10878808
20.

Role of presenilin in gamma-secretase cleavage of amyloid precursor protein.

Xia W.

Exp Gerontol. 2000 Jul;35(4):453-60. Review.

PMID:
10959033
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