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Results: 1 to 20 of 134

Similar articles for PubMed (Select 15545625)

1.

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex.

Brugarolas J, Lei K, Hurley RL, Manning BD, Reiling JH, Hafen E, Witters LA, Ellisen LW, Kaelin WG Jr.

Genes Dev. 2004 Dec 1;18(23):2893-904. Epub 2004 Nov 15.

2.

Regulation of mTOR and cell growth in response to energy stress by REDD1.

Sofer A, Lei K, Johannessen CM, Ellisen LW.

Mol Cell Biol. 2005 Jul;25(14):5834-45.

3.

Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.

Wolff NC, Vega-Rubin-de-Celis S, Xie XJ, Castrillon DH, Kabbani W, Brugarolas J.

Mol Cell Biol. 2011 May;31(9):1870-84. doi: 10.1128/MCB.01393-10. Epub 2011 Mar 7.

4.

Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent.

Jaeschke A, Hartkamp J, Saitoh M, Roworth W, Nobukuni T, Hodges A, Sampson J, Thomas G, Lamb R.

J Cell Biol. 2002 Oct 28;159(2):217-24. Epub 2002 Oct 28.

5.

Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling.

DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW.

Genes Dev. 2008 Jan 15;22(2):239-51. doi: 10.1101/gad.1617608.

6.

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR.

Zhang H, Cicchetti G, Onda H, Koon HB, Asrican K, Bajraszewski N, Vazquez F, Carpenter CL, Kwiatkowski DJ.

J Clin Invest. 2003 Oct;112(8):1223-33.

7.

Growth control under stress: mTOR regulation through the REDD1-TSC pathway.

Ellisen LW.

Cell Cycle. 2005 Nov;4(11):1500-02. Epub 2005 Nov 1. Review.

PMID:
16258273
8.
9.

The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb.

Nobukini T, Thomas G.

Novartis Found Symp. 2004;262:148-54; discussion 154-9, 265-8. Review.

PMID:
15562827
10.

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions.

Matthew EM, Hart LS, Astrinidis A, Navaraj A, Dolloff NG, Dicker DT, Henske EP, El-Deiry WS.

Cell Cycle. 2009 Dec 15;8(24):4168-75.

11.

Acute alcohol intoxication increases REDD1 in skeletal muscle.

Lang CH, Frost RA, Vary TC.

Alcohol Clin Exp Res. 2008 May;32(5):796-805. doi: 10.1111/j.1530-0277.2008.00637.x. Epub 2008 Mar 11.

PMID:
18336631
13.

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses.

Smith EM, Finn SG, Tee AR, Browne GJ, Proud CG.

J Biol Chem. 2005 May 13;280(19):18717-27. Epub 2005 Mar 16.

14.

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity.

Hahn-Windgassen A, Nogueira V, Chen CC, Skeen JE, Sonenberg N, Hay N.

J Biol Chem. 2005 Sep 16;280(37):32081-9. Epub 2005 Jul 15.

15.
16.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

17.

Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway.

Jozwiak J, Jozwiak S, Grzela T, Lazarczyk M.

Neuromolecular Med. 2005;7(4):287-96. Review.

PMID:
16391386
19.

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling.

Inoki K, Li Y, Zhu T, Wu J, Guan KL.

Nat Cell Biol. 2002 Sep;4(9):648-57.

PMID:
12172553
20.
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