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Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity.

Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15313-7. Epub 2004 Oct 14.


JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.

Putcha GV, Le S, Frank S, Besirli CG, Clark K, Chu B, Alix S, Youle RJ, LaMarche A, Maroney AC, Johnson EM Jr.

Neuron. 2003 Jun 19;38(6):899-914.


Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis.

Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, Strasser A, Johnson EM.

Neuron. 2001 Mar;29(3):615-28.


Essential role for the BH3-only protein Bim but redundant roles for Bax, Bcl-2, and Bcl-w in the control of granulocyte survival.

Villunger A, Scott C, Bouillet P, Strasser A.

Blood. 2003 Mar 15;101(6):2393-400. Epub 2002 Nov 14.


Stem cell factor promotes mast cell survival via inactivation of FOXO3a-mediated transcriptional induction and MEK-regulated phosphorylation of the proapoptotic protein Bim.

Möller C, Alfredsson J, Engström M, Wootz H, Xiang Z, Lennartsson J, Jönsson JI, Nilsson G.

Blood. 2005 Aug 15;106(4):1330-6. Epub 2005 Apr 26.


Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells.

Abutin RM, Chen J, Lung TK, Lloyd JA, Sawyer ST, Harada H.

Exp Hematol. 2009 Feb;37(2):151-8. doi: 10.1016/j.exphem.2008.10.008. Epub 2008 Dec 18.


Role of Bim in the survival pathway induced by Raf in epithelial cells.

Marani M, Hancock D, Lopes R, Tenev T, Downward J, Lemoine NR.

Oncogene. 2004 Apr 1;23(14):2431-41.


PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells.

Chen K, Tu Y, Zhang Y, Blair HC, Zhang L, Wu C.

J Biol Chem. 2008 Feb 1;283(5):2508-17. Epub 2007 Dec 6.


Identification of novel isoforms of the BH3 domain protein Bim which directly activate Bax to trigger apoptosis.

Marani M, Tenev T, Hancock D, Downward J, Lemoine NR.

Mol Cell Biol. 2002 Jun;22(11):3577-89.


Extracellular signal-regulated kinase activation by Neisseria gonorrhoeae downregulates epithelial cell proapoptotic proteins Bad and Bim.

Howie HL, Shiflett SL, So M.

Infect Immun. 2008 Jun;76(6):2715-21. doi: 10.1128/IAI.00153-08. Epub 2008 Apr 7.


TLR-dependent Bim phosphorylation in macrophages is mediated by ERK and is connected to proteasomal degradation of the protein.

Häcker G, Suttner K, Harada H, Kirschnek S.

Int Immunol. 2006 Dec;18(12):1749-57. Epub 2006 Nov 14.


EGFR-dependent downregulation of Bim in epithelial cells requires MAPK and PKC-delta activities.

Quadros MR, Connelly S, Kari C, Abrams MT, Wickstrom E, Rodeck U.

Cancer Biol Ther. 2006 May;5(5):498-504. Epub 2006 May 6.


BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak.

Zong WX, Lindsten T, Ross AJ, MacGregor GR, Thompson CB.

Genes Dev. 2001 Jun 15;15(12):1481-6.


Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma.

Ekert PG, Jabbour AM, Manoharan A, Heraud JE, Yu J, Pakusch M, Michalak EM, Kelly PN, Callus B, Kiefer T, Verhagen A, Silke J, Strasser A, Borner C, Vaux DL.

Blood. 2006 Sep 1;108(5):1461-8. Epub 2006 May 16.


Oncogenic B-RafV600E inhibits apoptosis and promotes ERK-dependent inactivation of Bad and Bim.

Sheridan C, Brumatti G, Martin SJ.

J Biol Chem. 2008 Aug 8;283(32):22128-35. doi: 10.1074/jbc.M800271200. Epub 2008 May 27.


Bim(L) displacing Bcl-x(L) promotes Bax translocation during TNFalpha-induced apoptosis.

Zhang L, Xing D, Chen M.

Apoptosis. 2008 Jul;13(7):950-8. doi: 10.1007/s10495-008-0226-5. Epub 2008 May 24.


Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis.

Hutcheson J, Scatizzi JC, Bickel E, Brown NJ, Bouillet P, Strasser A, Perlman H.

J Exp Med. 2005 Jun 20;201(12):1949-60.

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