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Results: 1 to 20 of 143

1.

Heparanase promotes the spontaneous metastasis of myeloma cells to bone.

Yang Y, Macleod V, Bendre M, Huang Y, Theus AM, Miao HQ, Kussie P, Yaccoby S, Epstein J, Suva LJ, Kelly T, Sanderson RD.

Blood. 2005 Feb 1;105(3):1303-9. Epub 2004 Oct 7.

PMID:
15471949
[PubMed - indexed for MEDLINE]
Free Article
2.

High heparanase activity in multiple myeloma is associated with elevated microvessel density.

Kelly T, Miao HQ, Yang Y, Navarro E, Kussie P, Huang Y, MacLeod V, Casciano J, Joseph L, Zhan F, Zangari M, Barlogie B, Shaughnessy J, Sanderson RD.

Cancer Res. 2003 Dec 15;63(24):8749-56.

PMID:
14695190
[PubMed - indexed for MEDLINE]
Free Article
3.

Expression of heparanase by primary breast tumors promotes bone resorption in the absence of detectable bone metastases.

Kelly T, Suva LJ, Huang Y, Macleod V, Miao HQ, Walker RC, Sanderson RD.

Cancer Res. 2005 Jul 1;65(13):5778-84.

PMID:
15994953
[PubMed - indexed for MEDLINE]
Free Article
4.

Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis.

Yang Y, Macleod V, Miao HQ, Theus A, Zhan F, Shaughnessy JD Jr, Sawyer J, Li JP, Zcharia E, Vlodavsky I, Sanderson RD.

J Biol Chem. 2007 May 4;282(18):13326-33. Epub 2007 Mar 8.

PMID:
17347152
[PubMed - indexed for MEDLINE]
Free Article
5.

The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy.

Yang Y, MacLeod V, Dai Y, Khotskaya-Sample Y, Shriver Z, Venkataraman G, Sasisekharan R, Naggi A, Torri G, Casu B, Vlodavsky I, Suva LJ, Epstein J, Yaccoby S, Shaughnessy JD Jr, Barlogie B, Sanderson RD.

Blood. 2007 Sep 15;110(6):2041-8. Epub 2007 May 29.

PMID:
17536013
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Soluble syndecan-1 promotes growth of myeloma tumors in vivo.

Yang Y, Yaccoby S, Liu W, Langford JK, Pumphrey CY, Theus A, Epstein J, Sanderson RD.

Blood. 2002 Jul 15;100(2):610-7.

PMID:
12091355
[PubMed - indexed for MEDLINE]
Free Article
7.

Heparan sulfate proteoglycans and heparanase--partners in osteolytic tumor growth and metastasis.

Sanderson RD, Yang Y, Suva LJ, Kelly T.

Matrix Biol. 2004 Oct;23(6):341-52. Review.

PMID:
15533755
[PubMed - indexed for MEDLINE]
8.

Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis.

Goldshmidt O, Zcharia E, Abramovitch R, Metzger S, Aingorn H, Friedmann Y, Schirrmacher V, Mitrani E, Vlodavsky I.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10031-6. Epub 2002 Jul 3.

PMID:
12097647
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Heparanase promotes growth, angiogenesis and survival of primary breast tumors.

Cohen I, Pappo O, Elkin M, San T, Bar-Shavit R, Hazan R, Peretz T, Vlodavsky I, Abramovitch R.

Int J Cancer. 2006 Apr 1;118(7):1609-17.

PMID:
16217746
[PubMed - indexed for MEDLINE]
10.

Function of heparanase in prostate tumorigenesis: potential for therapy.

Lerner I, Baraz L, Pikarsky E, Meirovitz A, Edovitsky E, Peretz T, Vlodavsky I, Elkin M.

Clin Cancer Res. 2008 Feb 1;14(3):668-76. doi: 10.1158/1078-0432.CCR-07-1866. Epub 2008 Jan 22.

PMID:
18212251
[PubMed - indexed for MEDLINE]
Free Article
11.

Regulation, function and clinical significance of heparanase in cancer metastasis and angiogenesis.

Ilan N, Elkin M, Vlodavsky I.

Int J Biochem Cell Biol. 2006;38(12):2018-39. Epub 2006 Jul 6. Review.

PMID:
16901744
[PubMed - indexed for MEDLINE]
12.

Heparanase enhances local and systemic osteolysis in multiple myeloma by upregulating the expression and secretion of RANKL.

Yang Y, Ren Y, Ramani VC, Nan L, Suva LJ, Sanderson RD.

Cancer Res. 2010 Nov 1;70(21):8329-38. doi: 10.1158/0008-5472.CAN-10-2179. Epub 2010 Oct 26.

PMID:
20978204
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Tumor-specific expression of alphavbeta3 integrin promotes spontaneous metastasis of breast cancer to bone.

Sloan EK, Pouliot N, Stanley KL, Chia J, Moseley JM, Hards DK, Anderson RL.

Breast Cancer Res. 2006;8(2):R20. Epub 2006 Apr 11.

PMID:
16608535
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis.

Barash U, Cohen-Kaplan V, Dowek I, Sanderson RD, Ilan N, Vlodavsky I.

FEBS J. 2010 Oct;277(19):3890-903. doi: 10.1111/j.1742-4658.2010.07799.x. Epub 2010 Aug 31. Review.

PMID:
20840586
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Early growth response gene 1 (EGR1) regulates heparanase gene transcription in tumor cells.

de Mestre AM, Rao S, Hornby JR, Soe-Htwe T, Khachigian LM, Hulett MD.

J Biol Chem. 2005 Oct 21;280(42):35136-47. Epub 2005 Aug 10.

PMID:
16093249
[PubMed - indexed for MEDLINE]
Free Article
16.

Spatial and temporal heparanase expression in colon mucosa throughout the adenoma-carcinoma sequence.

Doviner V, Maly B, Kaplan V, Gingis-Velitski S, Ilan N, Vlodavsky I, Sherman Y.

Mod Pathol. 2006 Jun;19(6):878-88.

PMID:
16607375
[PubMed - indexed for MEDLINE]
Free Article
17.

Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase.

Levy-Adam F, Abboud-Jarrous G, Guerrini M, Beccati D, Vlodavsky I, Ilan N.

J Biol Chem. 2005 May 27;280(21):20457-66. Epub 2005 Mar 10.

PMID:
15760902
[PubMed - indexed for MEDLINE]
Free Article
18.

Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity.

Ramani VC, Yang Y, Ren Y, Nan L, Sanderson RD.

J Biol Chem. 2011 Feb 25;286(8):6490-9. doi: 10.1074/jbc.M110.183277. Epub 2010 Dec 3.

PMID:
21131364
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Heparanase, heparin and the coagulation system in cancer progression.

Vlodavsky I, Ilan N, Nadir Y, Brenner B, Katz BZ, Naggi A, Torri G, Casu B, Sasisekharan R.

Thromb Res. 2007;120 Suppl 2:S112-20. Review. Erratum in: Thromb Res. 2008;123(1):187-90.

PMID:
18023704
[PubMed - indexed for MEDLINE]
20.

Inhibition of heparanase activity and tumor metastasis by laminarin sulfate and synthetic phosphorothioate oligodeoxynucleotides.

Miao HQ, Elkin M, Aingorn E, Ishai-Michaeli R, Stein CA, Vlodavsky I.

Int J Cancer. 1999 Oct 29;83(3):424-31.

PMID:
10495437
[PubMed - indexed for MEDLINE]

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